Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs

Rita Fürst, István Zupkó, Ágnes Berényi, Gerhard F. Ecker, Uwe Rinner

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Several derivatives of combretastatin have been prepared bearing a cyclopropyl unit instead of the natural occurring cis-double bond. Final products and synthetic intermediates were evaluated for their cytotoxic properties in two human cancer cell lines.

Original languageEnglish
Pages (from-to)6948-6951
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number24
DOIs
Publication statusPublished - Dec 15 2009

Fingerprint

Bearings (structural)
Cells
Derivatives
Cell Line
Neoplasms
combretastatin

Keywords

  • Anticancer drug
  • Colchicine
  • Combretastatin
  • Stilbene
  • Tubulin binding

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs. / Fürst, Rita; Zupkó, István; Berényi, Ágnes; Ecker, Gerhard F.; Rinner, Uwe.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 19, No. 24, 15.12.2009, p. 6948-6951.

Research output: Contribution to journalArticle

Fürst, Rita ; Zupkó, István ; Berényi, Ágnes ; Ecker, Gerhard F. ; Rinner, Uwe. / Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs. In: Bioorganic and Medicinal Chemistry Letters. 2009 ; Vol. 19, No. 24. pp. 6948-6951.
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