Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs

Rita Fürst; István Zupkó; Ágnes Berényi; Gerhard F. Ecker; Uwe Rinner

doi:10.1016/j.bmcl.2009.10.064

Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs

Rita Fürst, István Zupkó, Ágnes Berényi, Gerhard F. Ecker, Uwe Rinner^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Several derivatives of combretastatin have been prepared bearing a cyclopropyl unit instead of the natural occurring cis-double bond. Final products and synthetic intermediates were evaluated for their cytotoxic properties in two human cancer cell lines.

Original language	English
Pages (from-to)	6948-6951
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	24
DOIs	https://doi.org/10.1016/j.bmcl.2009.10.064
Publication status	Published - Dec 15 2009
Externally published	Yes

Keywords

Anticancer drug
Colchicine
Combretastatin
Stilbene
Tubulin binding

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2009.10.064

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title = "Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs",

abstract = "Several derivatives of combretastatin have been prepared bearing a cyclopropyl unit instead of the natural occurring cis-double bond. Final products and synthetic intermediates were evaluated for their cytotoxic properties in two human cancer cell lines.",

keywords = "Anticancer drug, Colchicine, Combretastatin, Stilbene, Tubulin binding",

author = "Rita F{\"u}rst and Istv{\'a}n Zupk{\'o} and {\'A}gnes Ber{\'e}nyi and Ecker, {Gerhard F.} and Uwe Rinner",

note = "Funding Information: The authors (R.F. and U.R.) thank the Fonds zur F{\"o}rderung der wissenschaftlichen Forschung (FWF) for financial support of this work (Project FWF-R45-N19).",

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doi = "10.1016/j.bmcl.2009.10.064",

language = "English",

volume = "19",

pages = "6948--6951",

journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs

AU - Fürst, Rita

AU - Zupkó, István

AU - Berényi, Ágnes

AU - Ecker, Gerhard F.

AU - Rinner, Uwe

N1 - Funding Information: The authors (R.F. and U.R.) thank the Fonds zur Förderung der wissenschaftlichen Forschung (FWF) for financial support of this work (Project FWF-R45-N19).

PY - 2009/12/15

Y1 - 2009/12/15

N2 - Several derivatives of combretastatin have been prepared bearing a cyclopropyl unit instead of the natural occurring cis-double bond. Final products and synthetic intermediates were evaluated for their cytotoxic properties in two human cancer cell lines.

AB - Several derivatives of combretastatin have been prepared bearing a cyclopropyl unit instead of the natural occurring cis-double bond. Final products and synthetic intermediates were evaluated for their cytotoxic properties in two human cancer cell lines.

KW - Anticancer drug

KW - Colchicine

KW - Combretastatin

KW - Stilbene

KW - Tubulin binding

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U2 - 10.1016/j.bmcl.2009.10.064

DO - 10.1016/j.bmcl.2009.10.064

M3 - Article

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AN - SCOPUS:71849087235

SN - 0960-894X

VL - 19

SP - 6948

EP - 6951

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 24

ER -

Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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