Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs

Rita Fürst; István Zupkó; Ágnes Berényi; Gerhard F. Ecker; Uwe Rinner

doi:10.1016/j.bmcl.2009.10.064

Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs

Rita Fürst, István Zupkó, Ágnes Berényi, Gerhard F. Ecker, Uwe Rinner^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Several derivatives of combretastatin have been prepared bearing a cyclopropyl unit instead of the natural occurring cis-double bond. Final products and synthetic intermediates were evaluated for their cytotoxic properties in two human cancer cell lines.

Original language	English
Pages (from-to)	6948-6951
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	24
DOIs	https://doi.org/10.1016/j.bmcl.2009.10.064
Publication status	Published - Dec 15 2009

Keywords

Anticancer drug
Colchicine
Combretastatin
Stilbene
Tubulin binding

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2009.10.064

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title = "Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs",

abstract = "Several derivatives of combretastatin have been prepared bearing a cyclopropyl unit instead of the natural occurring cis-double bond. Final products and synthetic intermediates were evaluated for their cytotoxic properties in two human cancer cell lines.",

keywords = "Anticancer drug, Colchicine, Combretastatin, Stilbene, Tubulin binding",

author = "Rita F{\"u}rst and Istv{\'a}n Zupk{\'o} and {\'A}gnes Ber{\'e}nyi and Ecker, {Gerhard F.} and Uwe Rinner",

note = "Funding Information: The authors (R.F. and U.R.) thank the Fonds zur F{\"o}rderung der wissenschaftlichen Forschung (FWF) for financial support of this work (Project FWF-R45-N19).",

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T1 - Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs

AU - Fürst, Rita

AU - Zupkó, István

AU - Berényi, Ágnes

AU - Ecker, Gerhard F.

AU - Rinner, Uwe

N1 - Funding Information: The authors (R.F. and U.R.) thank the Fonds zur Förderung der wissenschaftlichen Forschung (FWF) for financial support of this work (Project FWF-R45-N19).

PY - 2009/12/15

Y1 - 2009/12/15

N2 - Several derivatives of combretastatin have been prepared bearing a cyclopropyl unit instead of the natural occurring cis-double bond. Final products and synthetic intermediates were evaluated for their cytotoxic properties in two human cancer cell lines.

AB - Several derivatives of combretastatin have been prepared bearing a cyclopropyl unit instead of the natural occurring cis-double bond. Final products and synthetic intermediates were evaluated for their cytotoxic properties in two human cancer cell lines.

KW - Anticancer drug

KW - Colchicine

KW - Combretastatin

KW - Stilbene

KW - Tubulin binding

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DO - 10.1016/j.bmcl.2009.10.064

M3 - Article

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 24

ER -

Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs

Abstract

Keywords

ASJC Scopus subject areas

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