Switching to multiple daily insulin injections in children and adolescents with type 1 diabetes: Revisiting benefits from Oman

S. W. Sharef, Irfan Ullah, Azza Al-Shidhani, Tariq Al-Farsi, Saif Al-Yaarubi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: Optimal glycemic control is an important goal in the management of type 1 diabetes mellitus (T1DM). Although the use of multiple daily injections (MDI) is a common regimen worldwide, its use is not yet universal in many countries. Our aim was to evaluate the effects of switching from a twice daily (BID) to a MDI insulin regimen in children and adolescents with T1DM in order to revisit its benefits in the Omani population. Methods: We conducted a retrospective cohort study of children and adolescents with T1DM at Sultan Qaboos University Hospital, Muscat, Oman, between January 2007 and June 2013. Patients using the BID regimen for more than six months who were then switched to MDI were included in the analysis. We compared glycated hemoglobin levels (HbA1c) before and after the regimen change. Results: Fifty-three children were eligible for the study. Ten patients were excluded for various reasons. The remaining 43 patients were 58% male and 42% female, with a mean age of 9.4±3.7 years. There was significant decrease in the overall mean HbA1c level from baseline (10.0) compared to three months after switching to MDI (9.5); p=0.023. Nevertheless, the improvement was not significant in the subsequent follow-up visits at six and nine months. The reduction in HbA1c values was observed mainly in children five to 11 years. Conclusions: Switching from a BID to MDI insulin regimen has favorable effects on the overall control of T1DM in children and adolescents, as assessed by HbA1c levels. In addition, this regimen has been proved to be safe and well tolerated by patients.

Original languageEnglish
Pages (from-to)83-89
Number of pages7
JournalOman Medical Journal
Volume30
Issue number2
DOIs
Publication statusPublished - 2015

Fingerprint

Oman
Type 1 Diabetes Mellitus
Insulin
Injections
Glycosylated Hemoglobin A
Cohort Studies
Retrospective Studies
Population

Keywords

  • Adolescent
  • Children
  • Diabetes mellitus
  • Glycosylated
  • Hemoglobin A
  • Insulin
  • Insulin
  • Long-acting
  • Oman
  • Short-acting
  • Type 1

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Switching to multiple daily insulin injections in children and adolescents with type 1 diabetes : Revisiting benefits from Oman. / Sharef, S. W.; Ullah, Irfan; Al-Shidhani, Azza; Al-Farsi, Tariq; Al-Yaarubi, Saif.

In: Oman Medical Journal, Vol. 30, No. 2, 2015, p. 83-89.

Research output: Contribution to journalArticle

@article{2eca05b1264c4477b5608b461ac5ae57,
title = "Switching to multiple daily insulin injections in children and adolescents with type 1 diabetes: Revisiting benefits from Oman",
abstract = "Objectives: Optimal glycemic control is an important goal in the management of type 1 diabetes mellitus (T1DM). Although the use of multiple daily injections (MDI) is a common regimen worldwide, its use is not yet universal in many countries. Our aim was to evaluate the effects of switching from a twice daily (BID) to a MDI insulin regimen in children and adolescents with T1DM in order to revisit its benefits in the Omani population. Methods: We conducted a retrospective cohort study of children and adolescents with T1DM at Sultan Qaboos University Hospital, Muscat, Oman, between January 2007 and June 2013. Patients using the BID regimen for more than six months who were then switched to MDI were included in the analysis. We compared glycated hemoglobin levels (HbA1c) before and after the regimen change. Results: Fifty-three children were eligible for the study. Ten patients were excluded for various reasons. The remaining 43 patients were 58{\%} male and 42{\%} female, with a mean age of 9.4±3.7 years. There was significant decrease in the overall mean HbA1c level from baseline (10.0) compared to three months after switching to MDI (9.5); p=0.023. Nevertheless, the improvement was not significant in the subsequent follow-up visits at six and nine months. The reduction in HbA1c values was observed mainly in children five to 11 years. Conclusions: Switching from a BID to MDI insulin regimen has favorable effects on the overall control of T1DM in children and adolescents, as assessed by HbA1c levels. In addition, this regimen has been proved to be safe and well tolerated by patients.",
keywords = "Adolescent, Children, Diabetes mellitus, Glycosylated, Hemoglobin A, Insulin, Insulin, Long-acting, Oman, Short-acting, Type 1",
author = "Sharef, {S. W.} and Irfan Ullah and Azza Al-Shidhani and Tariq Al-Farsi and Saif Al-Yaarubi",
year = "2015",
doi = "10.5001/omj.2015.19",
language = "English",
volume = "30",
pages = "83--89",
journal = "Oman Medical Journal",
issn = "1999-768X",
publisher = "Oman Medical Specialty Board",
number = "2",

}

TY - JOUR

T1 - Switching to multiple daily insulin injections in children and adolescents with type 1 diabetes

T2 - Revisiting benefits from Oman

AU - Sharef, S. W.

AU - Ullah, Irfan

AU - Al-Shidhani, Azza

AU - Al-Farsi, Tariq

AU - Al-Yaarubi, Saif

PY - 2015

Y1 - 2015

N2 - Objectives: Optimal glycemic control is an important goal in the management of type 1 diabetes mellitus (T1DM). Although the use of multiple daily injections (MDI) is a common regimen worldwide, its use is not yet universal in many countries. Our aim was to evaluate the effects of switching from a twice daily (BID) to a MDI insulin regimen in children and adolescents with T1DM in order to revisit its benefits in the Omani population. Methods: We conducted a retrospective cohort study of children and adolescents with T1DM at Sultan Qaboos University Hospital, Muscat, Oman, between January 2007 and June 2013. Patients using the BID regimen for more than six months who were then switched to MDI were included in the analysis. We compared glycated hemoglobin levels (HbA1c) before and after the regimen change. Results: Fifty-three children were eligible for the study. Ten patients were excluded for various reasons. The remaining 43 patients were 58% male and 42% female, with a mean age of 9.4±3.7 years. There was significant decrease in the overall mean HbA1c level from baseline (10.0) compared to three months after switching to MDI (9.5); p=0.023. Nevertheless, the improvement was not significant in the subsequent follow-up visits at six and nine months. The reduction in HbA1c values was observed mainly in children five to 11 years. Conclusions: Switching from a BID to MDI insulin regimen has favorable effects on the overall control of T1DM in children and adolescents, as assessed by HbA1c levels. In addition, this regimen has been proved to be safe and well tolerated by patients.

AB - Objectives: Optimal glycemic control is an important goal in the management of type 1 diabetes mellitus (T1DM). Although the use of multiple daily injections (MDI) is a common regimen worldwide, its use is not yet universal in many countries. Our aim was to evaluate the effects of switching from a twice daily (BID) to a MDI insulin regimen in children and adolescents with T1DM in order to revisit its benefits in the Omani population. Methods: We conducted a retrospective cohort study of children and adolescents with T1DM at Sultan Qaboos University Hospital, Muscat, Oman, between January 2007 and June 2013. Patients using the BID regimen for more than six months who were then switched to MDI were included in the analysis. We compared glycated hemoglobin levels (HbA1c) before and after the regimen change. Results: Fifty-three children were eligible for the study. Ten patients were excluded for various reasons. The remaining 43 patients were 58% male and 42% female, with a mean age of 9.4±3.7 years. There was significant decrease in the overall mean HbA1c level from baseline (10.0) compared to three months after switching to MDI (9.5); p=0.023. Nevertheless, the improvement was not significant in the subsequent follow-up visits at six and nine months. The reduction in HbA1c values was observed mainly in children five to 11 years. Conclusions: Switching from a BID to MDI insulin regimen has favorable effects on the overall control of T1DM in children and adolescents, as assessed by HbA1c levels. In addition, this regimen has been proved to be safe and well tolerated by patients.

KW - Adolescent

KW - Children

KW - Diabetes mellitus

KW - Glycosylated

KW - Hemoglobin A

KW - Insulin

KW - Insulin

KW - Long-acting

KW - Oman

KW - Short-acting

KW - Type 1

UR - http://www.scopus.com/inward/record.url?scp=84926428592&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84926428592&partnerID=8YFLogxK

U2 - 10.5001/omj.2015.19

DO - 10.5001/omj.2015.19

M3 - Article

AN - SCOPUS:84926428592

VL - 30

SP - 83

EP - 89

JO - Oman Medical Journal

JF - Oman Medical Journal

SN - 1999-768X

IS - 2

ER -