Supplementation of selenium reduces chemical hepatocarcinogenesis in male Sprague-Dawley rats

Nasar Alwahaibi, Jamaludin Mohamed, Asha Alhamadani

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Selenium is an essential micronutrient mineral found mainly in soils and has been shown to prevent certain cancers in humans and animals. However, the dose and effects of selenium on liver cancer are controversial. The aim of this study was to investigate the effects of sodium selenite (4. mg/kg in drinking water) on chemically induced hepatocarcinogenesis in rats. Hepatocarcinogenesis was induced by a single intraperitoneal injection of diethyl nitrosamine (DEN) (200. mg/kg body weight) and 2 weeks later, the carcinogenic effect was promoted by 2-acetylaminofluorene (2-AAF) (0.02%). 44 Sprague-Dawley rats were divided into 6 groups: negative control, positive control (DEN+2-AAF), pre-selenium group (sodium selenite for 4 weeks, then DEN+2-AAF), pre-selenium control group (sodium selenite for 4 weeks, no DEN or 2-AAF), post-selenium group (sodium selenite for 8 weeks after 4 weeks of DEN injection) and post-selenium control group (sodium selenite for 8 weeks, no DEN or 2-AAF). Hematoxylin and eosin plus Gordon and Sweet's methods were used to stain liver tissues. The results showed that the number and sizes of hepatic nodules in pre- and post-selenium treatment groups significantly decreased (P

Original languageEnglish
Pages (from-to)119-123
Number of pages5
JournalJournal of Trace Elements in Medicine and Biology
Volume24
Issue number2
DOIs
Publication statusPublished - Apr 2010

Keywords

  • DEN
  • Hepatocarcinogenesis
  • Selenium

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry
  • Molecular Medicine

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