Successful pregnancies and abortions in symptomatic and asymptomatic Wilson's disease

Sanjib Sinha, A. B. Taly, L. K. Prashanth, G. R. Arunodaya, H. S. Swamy

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Background: There are only a few reports regarding the fertility and outcome of pregnancy in Wilson's disease (WD) and none from India. The authors in this study discuss various aspects of fertility in 16 women with WD. Methods: Retrospective analysis of data from a large cohort of WD, being followed at a tertiary care center. Results: Sixteen patients had conceived on 59 occasions with 30 successful pregnancies, 24 spontaneous abortions, 2 medical terminations of pregnancy and 3 still births. Diagnosis of WD was established after conception in 10 presymptomatic patients while six patients were already on treatment. Among these 16 patients, 9 had history of spontaneous abortions and 12 had successful pregnancies. None of the clinical features of WD changed during pregnancy, with or without treatment. All the 30 babies were full-term and delivered healthy. Conclusion: Recurrent abortions are common especially in women with untreated Wilson's disease. However, successful pregnancies and uneventful full-term delivery may occur in mothers of WD on treatment and in undiagnosed, undetected presymptomatic patients. Pregnancy does not seem to have adverse effect on the clinical course of Wilson's disease. Teratogenecity was not seen in the present series with low-dose penicillamine and zinc sulphate.

Original languageEnglish
Pages (from-to)37-40
Number of pages4
JournalJournal of the Neurological Sciences
Volume217
Issue number1
DOIs
Publication statusPublished - Jan 15 2004

Fingerprint

Asymptomatic Diseases
Hepatolenticular Degeneration
Pregnancy
Spontaneous Abortion
Fertility
Zinc Sulfate
Habitual Abortion
Penicillamine
Pregnancy Outcome
Tertiary Care Centers
India
Therapeutics
Mothers
Parturition

Keywords

  • Abortion
  • Conception
  • Effects of drugs
  • Fertility
  • Pregnancy
  • Teratogenecity
  • Wilson's disease

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Developmental Neuroscience
  • Neurology
  • Neuroscience(all)

Cite this

Successful pregnancies and abortions in symptomatic and asymptomatic Wilson's disease. / Sinha, Sanjib; Taly, A. B.; Prashanth, L. K.; Arunodaya, G. R.; Swamy, H. S.

In: Journal of the Neurological Sciences, Vol. 217, No. 1, 15.01.2004, p. 37-40.

Research output: Contribution to journalArticle

Sinha, Sanjib ; Taly, A. B. ; Prashanth, L. K. ; Arunodaya, G. R. ; Swamy, H. S. / Successful pregnancies and abortions in symptomatic and asymptomatic Wilson's disease. In: Journal of the Neurological Sciences. 2004 ; Vol. 217, No. 1. pp. 37-40.
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