Substituted benzimidazoles. Part I. Synthesis and properties of some 2-aryl-5-fluoro-6-(4-methyl-1-piperazinyl)-1H-benzimidazoles

Mustafa M. El-Abadelah, Salim S. Sabri, Musa H Abu Zarga, Raid J. Abdel-Jalil

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

2-Aryl-5-fluoro-6-(4-methyl-1-piperazinyl)benzimidazoles (8a-k) were synthesized for bioassay via interaction of 4-fluoro-5-(4-methyl-1-piperazinyl)-1,2-diaminobenzene (6) with the appropriate aldehyde. The intermediate Schiff bases (7a-k) were isolated and converted, thermally in nitrobenzene, to the respective heterocycles (8a-k). However, none of the tested model compounds (8c-e) showed any significant in vitro activity against Pseudomonas aeruginosa, Staphylococcus aureus, Aspergillus parasiticus and Candida albicans at concentration ≤ 100 μg/ml.

Original languageEnglish
Pages (from-to)2713-2728
Number of pages16
JournalHeterocycles
Volume41
Issue number12
Publication statusPublished - Dec 1 1995

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Benzimidazoles
Schiff Bases
Bioassay
Candida
Aspergillus
Candida albicans
Aldehydes
Biological Assay
Pseudomonas aeruginosa
Staphylococcus aureus
1,2-diaminobenzene
In Vitro Techniques
nitrobenzene

ASJC Scopus subject areas

  • Pharmacology
  • Organic Chemistry
  • Analytical Chemistry

Cite this

Substituted benzimidazoles. Part I. Synthesis and properties of some 2-aryl-5-fluoro-6-(4-methyl-1-piperazinyl)-1H-benzimidazoles. / El-Abadelah, Mustafa M.; Sabri, Salim S.; Zarga, Musa H Abu; Abdel-Jalil, Raid J.

In: Heterocycles, Vol. 41, No. 12, 01.12.1995, p. 2713-2728.

Research output: Contribution to journalArticle

El-Abadelah, Mustafa M. ; Sabri, Salim S. ; Zarga, Musa H Abu ; Abdel-Jalil, Raid J. / Substituted benzimidazoles. Part I. Synthesis and properties of some 2-aryl-5-fluoro-6-(4-methyl-1-piperazinyl)-1H-benzimidazoles. In: Heterocycles. 1995 ; Vol. 41, No. 12. pp. 2713-2728.
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