Abstract
2-Aryl-5-fluoro-6-(4-methyl-1-piperazinyl)benzimidazoles (8a-k) were synthesized for bioassay via interaction of 4-fluoro-5-(4-methyl-1-piperazinyl)-1,2-diaminobenzene (6) with the appropriate aldehyde. The intermediate Schiff bases (7a-k) were isolated and converted, thermally in nitrobenzene, to the respective heterocycles (8a-k). However, none of the tested model compounds (8c-e) showed any significant in vitro activity against Pseudomonas aeruginosa, Staphylococcus aureus, Aspergillus parasiticus and Candida albicans at concentration ≤ 100 μg/ml.
| Original language | English |
|---|---|
| Pages (from-to) | 2713-2728 |
| Number of pages | 16 |
| Journal | Heterocycles |
| Volume | 41 |
| Issue number | 12 |
| Publication status | Published - Dec 1 1995 |
ASJC Scopus subject areas
- Pharmacology
- Organic Chemistry
- Analytical Chemistry
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El-Abadelah, M. M., Sabri, S. S., Zarga, M. H. A., & Abdel-Jalil, R. J. (1995). Substituted benzimidazoles. Part I. Synthesis and properties of some 2-aryl-5-fluoro-6-(4-methyl-1-piperazinyl)-1H-benzimidazoles. Heterocycles, 41(12), 2713-2728.