Abstract
2-Aryl-5-fluoro-6-(4-methyl-1-piperazinyl)benzimidazoles (8a-k) were synthesized for bioassay via interaction of 4-fluoro-5-(4-methyl-1-piperazinyl)-1,2-diaminobenzene (6) with the appropriate aldehyde. The intermediate Schiff bases (7a-k) were isolated and converted, thermally in nitrobenzene, to the respective heterocycles (8a-k). However, none of the tested model compounds (8c-e) showed any significant in vitro activity against Pseudomonas aeruginosa, Staphylococcus aureus, Aspergillus parasiticus and Candida albicans at concentration ≤ 100 μg/ml.
| Original language | English |
|---|---|
| Pages (from-to) | 2713-2728 |
| Number of pages | 16 |
| Journal | Heterocycles |
| Volume | 41 |
| Issue number | 12 |
| Publication status | Published - Dec 1 1995 |
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ASJC Scopus subject areas
- Pharmacology
- Organic Chemistry
- Analytical Chemistry
Cite this
Substituted benzimidazoles. Part I. Synthesis and properties of some 2-aryl-5-fluoro-6-(4-methyl-1-piperazinyl)-1H-benzimidazoles. / El-Abadelah, Mustafa M.; Sabri, Salim S.; Zarga, Musa H Abu; Abdel-Jalil, Raid J.
In: Heterocycles, Vol. 41, No. 12, 01.12.1995, p. 2713-2728.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Substituted benzimidazoles. Part I. Synthesis and properties of some 2-aryl-5-fluoro-6-(4-methyl-1-piperazinyl)-1H-benzimidazoles
AU - El-Abadelah, Mustafa M.
AU - Sabri, Salim S.
AU - Zarga, Musa H Abu
AU - Abdel-Jalil, Raid J.
PY - 1995/12/1
Y1 - 1995/12/1
N2 - 2-Aryl-5-fluoro-6-(4-methyl-1-piperazinyl)benzimidazoles (8a-k) were synthesized for bioassay via interaction of 4-fluoro-5-(4-methyl-1-piperazinyl)-1,2-diaminobenzene (6) with the appropriate aldehyde. The intermediate Schiff bases (7a-k) were isolated and converted, thermally in nitrobenzene, to the respective heterocycles (8a-k). However, none of the tested model compounds (8c-e) showed any significant in vitro activity against Pseudomonas aeruginosa, Staphylococcus aureus, Aspergillus parasiticus and Candida albicans at concentration ≤ 100 μg/ml.
AB - 2-Aryl-5-fluoro-6-(4-methyl-1-piperazinyl)benzimidazoles (8a-k) were synthesized for bioassay via interaction of 4-fluoro-5-(4-methyl-1-piperazinyl)-1,2-diaminobenzene (6) with the appropriate aldehyde. The intermediate Schiff bases (7a-k) were isolated and converted, thermally in nitrobenzene, to the respective heterocycles (8a-k). However, none of the tested model compounds (8c-e) showed any significant in vitro activity against Pseudomonas aeruginosa, Staphylococcus aureus, Aspergillus parasiticus and Candida albicans at concentration ≤ 100 μg/ml.
UR - http://www.scopus.com/inward/record.url?scp=0001007786&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0001007786&partnerID=8YFLogxK
M3 - Article
VL - 41
SP - 2713
EP - 2728
JO - Heterocycles
JF - Heterocycles
SN - 0385-5414
IS - 12
ER -