Substituted benzimidazoles. Part I. Synthesis and properties of some 2-aryl-5-fluoro-6-(4-methyl-1-piperazinyl)-1H-benzimidazoles

Mustafa M. El-Abadelah; Salim S. Sabri; Musa H.Abu Zarga; Raid J. Abdel-Jalil

doi:10.3987/com-95-7141

Substituted benzimidazoles. Part I. Synthesis and properties of some 2-aryl-5-fluoro-6-(4-methyl-1-piperazinyl)-1H-benzimidazoles

Mustafa M. El-Abadelah^*, Salim S. Sabri, Musa H.Abu Zarga, Raid J. Abdel-Jalil

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

2-Aryl-5-fluoro-6-(4-methyl-1-piperazinyl)benzimidazoles (8a-k) were synthesized for bioassay via interaction of 4-fluoro-5-(4-methyl-1-piperazinyl)-1,2-diaminobenzene (6) with the appropriate aldehyde. The intermediate Schiff bases (7a-k) were isolated and converted, thermally in nitrobenzene, to the respective heterocycles (8a-k). However, none of the tested model compounds (8c-e) showed any significant in vitro activity against Pseudomonas aeruginosa, Staphylococcus aureus, Aspergillus parasiticus and Candida albicans at concentration ≤ 100 μg/ml.

Original language	English
Pages (from-to)	2713-2728
Number of pages	16
Journal	Heterocycles
Volume	41
Issue number	12
DOIs	https://doi.org/10.3987/com-95-7141
Publication status	Published - Dec 1 1995
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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abstract = "2-Aryl-5-fluoro-6-(4-methyl-1-piperazinyl)benzimidazoles (8a-k) were synthesized for bioassay via interaction of 4-fluoro-5-(4-methyl-1-piperazinyl)-1,2-diaminobenzene (6) with the appropriate aldehyde. The intermediate Schiff bases (7a-k) were isolated and converted, thermally in nitrobenzene, to the respective heterocycles (8a-k). However, none of the tested model compounds (8c-e) showed any significant in vitro activity against Pseudomonas aeruginosa, Staphylococcus aureus, Aspergillus parasiticus and Candida albicans at concentration ≤ 100 μg/ml.",

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AU - El-Abadelah, Mustafa M.

AU - Sabri, Salim S.

AU - Zarga, Musa H.Abu

AU - Abdel-Jalil, Raid J.

PY - 1995/12/1

Y1 - 1995/12/1

N2 - 2-Aryl-5-fluoro-6-(4-methyl-1-piperazinyl)benzimidazoles (8a-k) were synthesized for bioassay via interaction of 4-fluoro-5-(4-methyl-1-piperazinyl)-1,2-diaminobenzene (6) with the appropriate aldehyde. The intermediate Schiff bases (7a-k) were isolated and converted, thermally in nitrobenzene, to the respective heterocycles (8a-k). However, none of the tested model compounds (8c-e) showed any significant in vitro activity against Pseudomonas aeruginosa, Staphylococcus aureus, Aspergillus parasiticus and Candida albicans at concentration ≤ 100 μg/ml.

AB - 2-Aryl-5-fluoro-6-(4-methyl-1-piperazinyl)benzimidazoles (8a-k) were synthesized for bioassay via interaction of 4-fluoro-5-(4-methyl-1-piperazinyl)-1,2-diaminobenzene (6) with the appropriate aldehyde. The intermediate Schiff bases (7a-k) were isolated and converted, thermally in nitrobenzene, to the respective heterocycles (8a-k). However, none of the tested model compounds (8c-e) showed any significant in vitro activity against Pseudomonas aeruginosa, Staphylococcus aureus, Aspergillus parasiticus and Candida albicans at concentration ≤ 100 μg/ml.

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Substituted benzimidazoles. Part I. Synthesis and properties of some 2-aryl-5-fluoro-6-(4-methyl-1-piperazinyl)-1H-benzimidazoles

Abstract

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