Sub-optimal serum gentamicin concentrations in sickle cell disease patients utilizing the Hartford protocol

What is known and Objectives: Several studies have reported that use of the Hartford nomogram in different patients' population was associated with low serum gentamicin concentrations (SGC) at different intervals or midpoints. This study was intended to determine the prevalence and predictors of SGC in patients with sickle cell disease (SCD) as another population representing low SGC while utilizing the Hartford protocol. Methods: This retrospective observational study was carried out in a University-teaching hospital in Oman. The study was conducted from January 2005 through May 2008 and included all adult patients with SCD admitted during that time. Fourhundred and seven SGC representing 248 SCD patients were evaluated. The serum gentamicin concentration was considered sub-optimal if it was 23 years of age (95% CI: 1·14-3·45; P = 0·015). Patients with creatinine clearance of ≥200 mL/min were 5Æ20 times more likely to have sub-optimal SGC compared with those with creatinine clearance