Abstract
What is known and Objectives: Several studies have reported that use of the Hartford nomogram in different patients' population was associated with low serum gentamicin concentrations (SGC) at different intervals or midpoints. This study was intended to determine the prevalence and predictors of SGC in patients with sickle cell disease (SCD) as another population representing low SGC while utilizing the Hartford protocol. Methods: This retrospective observational study was carried out in a University-teaching hospital in Oman. The study was conducted from January 2005 through May 2008 and included all adult patients with SCD admitted during that time. Fourhundred and seven SGC representing 248 SCD patients were evaluated. The serum gentamicin concentration was considered sub-optimal if it was 23 years of age (95% CI: 1·14-3·45; P = 0·015). Patients with creatinine clearance of ≥200 mL/min were 5Æ20 times more likely to have sub-optimal SGC compared with those with creatinine clearance
| Original language | English |
|---|---|
| Pages (from-to) | 212-216 |
| Number of pages | 5 |
| Journal | Journal of Clinical Pharmacy and Therapeutics |
| Volume | 37 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Apr 2012 |
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Keywords
- Gentamicin extended interval dosing
- Hartford nomogram
- Oman
- Sickle cell disease
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology
Cite this
Sub-optimal serum gentamicin concentrations in sickle cell disease patients utilizing the Hartford protocol. / Abusham, Ahmed A.; Mohammed, A. H.; Alkindi, S. S.; Hassan, M. M.; Al-Zakwani, I. S.
In: Journal of Clinical Pharmacy and Therapeutics, Vol. 37, No. 2, 04.2012, p. 212-216.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sub-optimal serum gentamicin concentrations in sickle cell disease patients utilizing the Hartford protocol
AU - Abusham, Ahmed A.
AU - Mohammed, A. H.
AU - Alkindi, S. S.
AU - Hassan, M. M.
AU - Al-Zakwani, I. S.
PY - 2012/4
Y1 - 2012/4
N2 - What is known and Objectives: Several studies have reported that use of the Hartford nomogram in different patients' population was associated with low serum gentamicin concentrations (SGC) at different intervals or midpoints. This study was intended to determine the prevalence and predictors of SGC in patients with sickle cell disease (SCD) as another population representing low SGC while utilizing the Hartford protocol. Methods: This retrospective observational study was carried out in a University-teaching hospital in Oman. The study was conducted from January 2005 through May 2008 and included all adult patients with SCD admitted during that time. Fourhundred and seven SGC representing 248 SCD patients were evaluated. The serum gentamicin concentration was considered sub-optimal if it was 23 years of age (95% CI: 1·14-3·45; P = 0·015). Patients with creatinine clearance of ≥200 mL/min were 5Æ20 times more likely to have sub-optimal SGC compared with those with creatinine clearance
AB - What is known and Objectives: Several studies have reported that use of the Hartford nomogram in different patients' population was associated with low serum gentamicin concentrations (SGC) at different intervals or midpoints. This study was intended to determine the prevalence and predictors of SGC in patients with sickle cell disease (SCD) as another population representing low SGC while utilizing the Hartford protocol. Methods: This retrospective observational study was carried out in a University-teaching hospital in Oman. The study was conducted from January 2005 through May 2008 and included all adult patients with SCD admitted during that time. Fourhundred and seven SGC representing 248 SCD patients were evaluated. The serum gentamicin concentration was considered sub-optimal if it was 23 years of age (95% CI: 1·14-3·45; P = 0·015). Patients with creatinine clearance of ≥200 mL/min were 5Æ20 times more likely to have sub-optimal SGC compared with those with creatinine clearance
KW - Gentamicin extended interval dosing
KW - Hartford nomogram
KW - Oman
KW - Sickle cell disease
UR - http://www.scopus.com/inward/record.url?scp=84857966622&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84857966622&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2710.2011.01261.x
DO - 10.1111/j.1365-2710.2011.01261.x
M3 - Article
C2 - 21501204
AN - SCOPUS:84857966622
VL - 37
SP - 212
EP - 216
JO - Journal of Clinical Pharmacy and Therapeutics
JF - Journal of Clinical Pharmacy and Therapeutics
SN - 0269-4727
IS - 2
ER -