Stripping voltammetry of tinidazole in solubilized system and biological fluids

Rajeev Jain; Jahangir Ahmad Rather

doi:10.1016/j.colsurfa.2011.01.045

Stripping voltammetry of tinidazole in solubilized system and biological fluids

Rajeev Jain^*, Jahangir Ahmad Rather

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

The adsorptive voltammetric behaviour of tinidazole onto the HMDE was investigated and validated in solubilized system and biological fluids by CV, SWCAdSV and DPCAdSV. Addition of CTAB to the solution containing drug enhanced the peak current while anionic and non-ionic surfactants showed an opposite effect. The electrode process is irreversible and adsorption controlled. Various chemical and instrumental parameters affecting the monitored electroanalytical response were investigated and optimized for tinidazole determination. Under optimized conditions; the adsorptive stripping peak current is linear over the concentration range 7.0×10^-9 to 6.2×10^-7mol/L with detection limit of 4.5×10^-10mol/L. The precision of the proposed method in terms of RSD is 1.2% and mean recovery of 100.01%. The applicability of proposed method is further extended to in vitro determination of the drug in biological fluids.

Original language	English
Pages (from-to)	27-33
Number of pages	7
Journal	Colloids and Surfaces A: Physicochemical and Engineering Aspects
Volume	378
Issue number	1-3
DOIs	https://doi.org/10.1016/j.colsurfa.2011.01.045
Publication status	Published - Mar 20 2011
Externally published	Yes

Keywords

Biological fluids
Cetyltrimethylamonium bromide (CTAB)
DPCAdSV
HMDE
SWCAdSV
Tinidazole (Tindz.)

ASJC Scopus subject areas

Surfaces and Interfaces
Physical and Theoretical Chemistry
Colloid and Surface Chemistry

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10.1016/j.colsurfa.2011.01.045

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title = "Stripping voltammetry of tinidazole in solubilized system and biological fluids",

abstract = "The adsorptive voltammetric behaviour of tinidazole onto the HMDE was investigated and validated in solubilized system and biological fluids by CV, SWCAdSV and DPCAdSV. Addition of CTAB to the solution containing drug enhanced the peak current while anionic and non-ionic surfactants showed an opposite effect. The electrode process is irreversible and adsorption controlled. Various chemical and instrumental parameters affecting the monitored electroanalytical response were investigated and optimized for tinidazole determination. Under optimized conditions; the adsorptive stripping peak current is linear over the concentration range 7.0×10-9 to 6.2×10-7mol/L with detection limit of 4.5×10-10mol/L. The precision of the proposed method in terms of RSD is 1.2% and mean recovery of 100.01%. The applicability of proposed method is further extended to in vitro determination of the drug in biological fluids.",

keywords = "Biological fluids, Cetyltrimethylamonium bromide (CTAB), DPCAdSV, HMDE, SWCAdSV, Tinidazole (Tindz.)",

author = "Rajeev Jain and Rather, {Jahangir Ahmad}",

year = "2011",

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doi = "10.1016/j.colsurfa.2011.01.045",

language = "English",

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number = "1-3",

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TY - JOUR

T1 - Stripping voltammetry of tinidazole in solubilized system and biological fluids

AU - Jain, Rajeev

AU - Rather, Jahangir Ahmad

PY - 2011/3/20

Y1 - 2011/3/20

N2 - The adsorptive voltammetric behaviour of tinidazole onto the HMDE was investigated and validated in solubilized system and biological fluids by CV, SWCAdSV and DPCAdSV. Addition of CTAB to the solution containing drug enhanced the peak current while anionic and non-ionic surfactants showed an opposite effect. The electrode process is irreversible and adsorption controlled. Various chemical and instrumental parameters affecting the monitored electroanalytical response were investigated and optimized for tinidazole determination. Under optimized conditions; the adsorptive stripping peak current is linear over the concentration range 7.0×10-9 to 6.2×10-7mol/L with detection limit of 4.5×10-10mol/L. The precision of the proposed method in terms of RSD is 1.2% and mean recovery of 100.01%. The applicability of proposed method is further extended to in vitro determination of the drug in biological fluids.

AB - The adsorptive voltammetric behaviour of tinidazole onto the HMDE was investigated and validated in solubilized system and biological fluids by CV, SWCAdSV and DPCAdSV. Addition of CTAB to the solution containing drug enhanced the peak current while anionic and non-ionic surfactants showed an opposite effect. The electrode process is irreversible and adsorption controlled. Various chemical and instrumental parameters affecting the monitored electroanalytical response were investigated and optimized for tinidazole determination. Under optimized conditions; the adsorptive stripping peak current is linear over the concentration range 7.0×10-9 to 6.2×10-7mol/L with detection limit of 4.5×10-10mol/L. The precision of the proposed method in terms of RSD is 1.2% and mean recovery of 100.01%. The applicability of proposed method is further extended to in vitro determination of the drug in biological fluids.

KW - Biological fluids

KW - Cetyltrimethylamonium bromide (CTAB)

KW - DPCAdSV

KW - HMDE

KW - SWCAdSV

KW - Tinidazole (Tindz.)

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IS - 1-3

ER -

Stripping voltammetry of tinidazole in solubilized system and biological fluids

Abstract

Keywords

ASJC Scopus subject areas

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