Stripping voltammetry of tinidazole in solubilized system and biological fluids

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Abstract

The adsorptive voltammetric behaviour of tinidazole onto the HMDE was investigated and validated in solubilized system and biological fluids by CV, SWCAdSV and DPCAdSV. Addition of CTAB to the solution containing drug enhanced the peak current while anionic and non-ionic surfactants showed an opposite effect. The electrode process is irreversible and adsorption controlled. Various chemical and instrumental parameters affecting the monitored electroanalytical response were investigated and optimized for tinidazole determination. Under optimized conditions; the adsorptive stripping peak current is linear over the concentration range 7.0×10-9 to 6.2×10-7mol/L with detection limit of 4.5×10-10mol/L. The precision of the proposed method in terms of RSD is 1.2% and mean recovery of 100.01%. The applicability of proposed method is further extended to in vitro determination of the drug in biological fluids.

Original languageEnglish
Pages (from-to)27-33
Number of pages7
JournalColloids and Surfaces A: Physicochemical and Engineering Aspects
Volume378
Issue number1-3
DOIs
Publication statusPublished - Mar 20 2011

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Keywords

  • Biological fluids
  • Cetyltrimethylamonium bromide (CTAB)
  • DPCAdSV
  • HMDE
  • SWCAdSV
  • Tinidazole (Tindz.)

ASJC Scopus subject areas

  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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