Stress, drugs and the evolution of reproductive restraint in malaria parasites

Sarah E. Reece, Eltayeb Ali, Petra Schneider, Hamza A. Babiker

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Life-history theory predicts that sexually reproducing organisms have evolved to resolve resourceallocation trade-offs between growth/survival versus reproduction, and current versus future reproduction. Malaria parasites replicate asexually in their vertebrate hosts, but must reproduce sexually to infect vectors and be transmitted to new hosts. As different specialized stages are required for these functions, the division of resources between these life-history components is a fundamental evolutionary problem. Here, we test how drug-sensitive and drug-resistant isolates of the human malaria parasite Plasmodium falciparum resolve the trade-off between in-host replication and between-host transmission when exposed to treatment with anti-malarial drugs. Previous studies have shown that parasites increase their investment in sexual stages when exposed to stressful conditions, such as drugs. However, we demonstrate that sensitive parasites facultatively decrease their investment in sexual stages when exposed to drugs. In contrast to previous studies, we tested parasites from a region where treatment with antimalarial drugs is common and transmission is seasonal. We hypothesize that when exposed to drugs, parasites invest in their survival and future transmission by diverting resources from reproduction to replication. Furthermore, as drug-resistant parasites did not adjust their investment when exposed to drugs, we suggest that parasites respond to changes in their proliferation (state) rather the presence of drugs.

Original languageEnglish
Pages (from-to)3123-3129
Number of pages7
JournalProceedings of the Royal Society B: Biological Sciences
Volume277
Issue number1697
DOIs
Publication statusPublished - Oct 22 2010

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malaria
Malaria
parasite
Parasites
drug
parasites
drugs
Pharmaceutical Preparations
antimalarials
Reproduction
Antimalarials
life history
Plasmodium falciparum
Survival
Falciparum Malaria
life history theory
resource
Vertebrates
vertebrates
trade-off

Keywords

  • Anti-malarial drug resistance
  • Gametocyte conversion
  • Life-history trade-offs
  • Plasmodium falciparum
  • Reproductive effort
  • Resource allocation

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Stress, drugs and the evolution of reproductive restraint in malaria parasites. / Reece, Sarah E.; Ali, Eltayeb; Schneider, Petra; Babiker, Hamza A.

In: Proceedings of the Royal Society B: Biological Sciences, Vol. 277, No. 1697, 22.10.2010, p. 3123-3129.

Research output: Contribution to journalArticle

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