Spurious hyperbilirubinemia caused by naproxen

Nafila Al Riyami; Amanda C. Zimmerman; Frances M. Rosenberg; Daniel T. Holmes

doi:10.1016/j.clinbiochem.2008.09.119

Spurious hyperbilirubinemia caused by naproxen

Nafila Al Riyami, Amanda C. Zimmerman, Frances M. Rosenberg, Daniel T. Holmes^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Objective: To confirm that the naproxen metabolite O-desmethylnaproxen interferes with the Jendrassik and Grof method for total bilirubin and was a possible cause of spurious hyperbilirubinemia in a case of naproxen overdose. Design and methods: Plasma was spiked with naproxen or O-desmethylnaproxen before total and direct bilirubin analysis. Results: O-desmethylnaproxen concentration showed a linear relationship with measured total bilirubin. Conclusion: O-demethylnaproxen interferes with the total bilirubin method. Interference of glucuronide metabolites of naproxen and O-demethylnaproxen is not excluded.

Original language	English
Pages (from-to)	129-131
Number of pages	3
Journal	Clinical Biochemistry
Volume	42
Issue number	1-2
DOIs	https://doi.org/10.1016/j.clinbiochem.2008.09.119
Publication status	Published - Jan 2009
Externally published	Yes

Keywords

Bilirubin
Diazonium compounds
Naproxen
Spectrophotometry

ASJC Scopus subject areas

Clinical Biochemistry

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10.1016/j.clinbiochem.2008.09.119

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title = "Spurious hyperbilirubinemia caused by naproxen",

abstract = "Objective: To confirm that the naproxen metabolite O-desmethylnaproxen interferes with the Jendrassik and Grof method for total bilirubin and was a possible cause of spurious hyperbilirubinemia in a case of naproxen overdose. Design and methods: Plasma was spiked with naproxen or O-desmethylnaproxen before total and direct bilirubin analysis. Results: O-desmethylnaproxen concentration showed a linear relationship with measured total bilirubin. Conclusion: O-demethylnaproxen interferes with the total bilirubin method. Interference of glucuronide metabolites of naproxen and O-demethylnaproxen is not excluded.",

keywords = "Bilirubin, Diazonium compounds, Naproxen, Spectrophotometry",

author = "{Al Riyami}, Nafila and Zimmerman, {Amanda C.} and Rosenberg, {Frances M.} and Holmes, {Daniel T.}",

year = "2009",

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doi = "10.1016/j.clinbiochem.2008.09.119",

language = "English",

volume = "42",

pages = "129--131",

journal = "Clinical Biochemistry",

issn = "0009-9120",

publisher = "Elsevier Inc.",

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}

TY - JOUR

T1 - Spurious hyperbilirubinemia caused by naproxen

AU - Al Riyami, Nafila

AU - Zimmerman, Amanda C.

AU - Rosenberg, Frances M.

AU - Holmes, Daniel T.

PY - 2009/1

Y1 - 2009/1

N2 - Objective: To confirm that the naproxen metabolite O-desmethylnaproxen interferes with the Jendrassik and Grof method for total bilirubin and was a possible cause of spurious hyperbilirubinemia in a case of naproxen overdose. Design and methods: Plasma was spiked with naproxen or O-desmethylnaproxen before total and direct bilirubin analysis. Results: O-desmethylnaproxen concentration showed a linear relationship with measured total bilirubin. Conclusion: O-demethylnaproxen interferes with the total bilirubin method. Interference of glucuronide metabolites of naproxen and O-demethylnaproxen is not excluded.

AB - Objective: To confirm that the naproxen metabolite O-desmethylnaproxen interferes with the Jendrassik and Grof method for total bilirubin and was a possible cause of spurious hyperbilirubinemia in a case of naproxen overdose. Design and methods: Plasma was spiked with naproxen or O-desmethylnaproxen before total and direct bilirubin analysis. Results: O-desmethylnaproxen concentration showed a linear relationship with measured total bilirubin. Conclusion: O-demethylnaproxen interferes with the total bilirubin method. Interference of glucuronide metabolites of naproxen and O-demethylnaproxen is not excluded.

KW - Bilirubin

KW - Diazonium compounds

KW - Naproxen

KW - Spectrophotometry

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DO - 10.1016/j.clinbiochem.2008.09.119

M3 - Article

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SN - 0009-9120

VL - 42

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EP - 131

JO - Clinical Biochemistry

JF - Clinical Biochemistry

IS - 1-2

ER -

Spurious hyperbilirubinemia caused by naproxen

Abstract

Keywords

ASJC Scopus subject areas

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