Spectrum of Tamoxifen Associated Endometrial Pathology in breast cancer patients

Asim Qureshi, Farhan Bukhari, Shahid Pervez

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The objective of the study was to determine the incidence and type of endometrial abnormalities in long term users of tamoxifen with breast cancer. All patients with a diagnosis of Oestrogen Receptor positive breast cancer on Tamoxifen therapy who had also undergone endometrial biopsy for abnormal bleeding or other symptoms were included. Among the 37 cases that had long term follow up available, 21(57%) had evidence of endometrial pathology. There were seven cases of simple hyperplasia and thirteen of endometrial polyp. Only one case of endometrial carcinoma was seen. These findings support the association between prolonged tamoxifen therapy and endometrial pathology of possible neoplastic potential. Endometrial pathology is dependent on duration of exposure to Tamoxifen, therefore, close follow up of such patients is recommended.

Original languageEnglish
Pages (from-to)249-250
Number of pages2
JournalJournal of the Pakistan Medical Association
Volume59
Issue number4
Publication statusPublished - Apr 2009

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Tamoxifen
Pathology
Breast Neoplasms
Endometrial Hyperplasia
Endometrial Neoplasms
Polyps
Estrogen Receptors
Hemorrhage
Biopsy
Incidence
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Spectrum of Tamoxifen Associated Endometrial Pathology in breast cancer patients. / Qureshi, Asim; Bukhari, Farhan; Pervez, Shahid.

In: Journal of the Pakistan Medical Association, Vol. 59, No. 4, 04.2009, p. 249-250.

Research output: Contribution to journalArticle

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