Spectrum of systemic lupus erythematosus in Oman

from childhood to adulthood

Asma Al Rasbi, Eiman Abdalla, Rabab Sultan, Nasreen Abdullah, Juma Al Kaabi, Ibrahim Al-Zakwani, Reem Abdawani

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

SLE is a disease that mainly affects women of childbearing age, however, a total of 15–20% of cases present in children. Although adult onset SLE (aSLE) and childhood onset SLE (cSLE) share the same diagnostic criteria, differences have been identified. The aim of this study is to compare the similarities and differences in between cSLE and aSLE in an Arab population from Oman. We evaluated 225 SLE patients, 139 adults and 86 children, who fulfilled the criteria for diagnosis. At disease onset, 99% of SLE cohort fulfilled the SLICC criteria; however the ACR 1997 criteria were fulfilled in 66% aSLE and 80% cSLE. The clinical features of SLE in cSLE showed higher frequency of renal (50 vs 19%; p < 0.001), musculoskeletal (67 vs 53%; p = 0.036) and pulmonary involvement (13 vs 2.9%, p = 0.005); while aSLE showed higher frequency of hematological (64 vs 49%; p = 0.25) and mucocutaneous (24 vs 10%; p = 0.13) involvement. The mean disease activity score at disease onset and during disease course was also higher in cSLE (13 vs 8.5; p < 0.0005) (16 vs 11.8; p < 0.0005), respectively. Differences in autoantibody profile were also noted in cSLE with higher positivity of anti-dsDNA and antiphospholipid antibody (94 vs 84%; p = 0.027) (53 vs 37%; p = 0.25), respectively. cSLE patients were more likely than aSLE to be treated with immunosuppressant such as cyclophosphamide (51 vs 22%; p < 0.001) and MMF (70 vs 54%; p = 0.019). Similarities and differences between aSLE and cSLE in a cohort from Oman of Arab ethnicity were identified. It appears that individual races and ethnicities may exhibit differences in disease susceptibility and manifestations.

Original languageEnglish
Pages (from-to)1691-1698
Number of pages8
JournalRheumatology International
Volume38
Issue number9
DOIs
Publication statusPublished - Sep 1 2018

Fingerprint

Oman
Systemic Lupus Erythematosus
Antiphospholipid Antibodies
Disease Susceptibility
Immunosuppressive Agents
Autoantibodies
Cyclophosphamide
Anti-Idiotypic Antibodies
Kidney
Lung
Population

Keywords

  • Adult SLE
  • Childhood SLE
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

Spectrum of systemic lupus erythematosus in Oman : from childhood to adulthood. / Al Rasbi, Asma; Abdalla, Eiman; Sultan, Rabab; Abdullah, Nasreen; Al Kaabi, Juma; Al-Zakwani, Ibrahim; Abdawani, Reem.

In: Rheumatology International, Vol. 38, No. 9, 01.09.2018, p. 1691-1698.

Research output: Contribution to journalArticle

Al Rasbi, Asma ; Abdalla, Eiman ; Sultan, Rabab ; Abdullah, Nasreen ; Al Kaabi, Juma ; Al-Zakwani, Ibrahim ; Abdawani, Reem. / Spectrum of systemic lupus erythematosus in Oman : from childhood to adulthood. In: Rheumatology International. 2018 ; Vol. 38, No. 9. pp. 1691-1698.
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