TY - JOUR
T1 - Spectrum of malignancy in mixed tumors of salivary gland
T2 - A morphological and immunohistochemical review of 23 cases
AU - Qureshi, Asim
AU - Barakzai, Abrar
AU - Ul Sahar, Najam
AU - Gulzar, Rubina
AU - Ahmad, Zubair
AU - Hassan, Sheema H.
PY - 2009/4/1
Y1 - 2009/4/1
N2 - Malignancy arising in mixed tumors of the salivary gland is a distinct entity that can occur sporadically or in association with a background of pleomorphic adenoma. Carcinoma arising with a background of pleomorphic adenoma is well documented. However, there are rare occurrences of aggressive de novo carcinosarcomas of the parotid that have been reported. Various cell lineages such as the epithelial glandular cells and the stromal spindle cells are involved. We report 23 cases of tumors of the salivary gland comprising 18 cases of carcinoma ex pleomorphic adenoma, four cases of carcinosarcoma of the parotid and one case of benign metastasizing pleomorphic adenoma. The occurrence of various malignancies suggests that this phenomenon is not very uncommon and should be looked for when reporting a mixed tumor.
AB - Malignancy arising in mixed tumors of the salivary gland is a distinct entity that can occur sporadically or in association with a background of pleomorphic adenoma. Carcinoma arising with a background of pleomorphic adenoma is well documented. However, there are rare occurrences of aggressive de novo carcinosarcomas of the parotid that have been reported. Various cell lineages such as the epithelial glandular cells and the stromal spindle cells are involved. We report 23 cases of tumors of the salivary gland comprising 18 cases of carcinoma ex pleomorphic adenoma, four cases of carcinosarcoma of the parotid and one case of benign metastasizing pleomorphic adenoma. The occurrence of various malignancies suggests that this phenomenon is not very uncommon and should be looked for when reporting a mixed tumor.
KW - Carcinoma ex pleomorphic adenoma
KW - Carcinosarcoma
KW - Malignant mixed tumor
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U2 - 10.4103/0377-4929.48904
DO - 10.4103/0377-4929.48904
M3 - Article
C2 - 19332899
AN - SCOPUS:63449104863
SN - 0377-4929
VL - 52
SP - 150
EP - 154
JO - Indian Journal of Pathology and Microbiology
JF - Indian Journal of Pathology and Microbiology
IS - 2
ER -