Spectrum of malignancy in mixed tumors of salivary gland: A morphological and immunohistochemical review of 23 cases

Asim Qureshi, Abrar Barakzai, Najam Ul Sahar, Rubina Gulzar, Zubair Ahmad, Sheema H. Hassan

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Malignancy arising in mixed tumors of the salivary gland is a distinct entity that can occur sporadically or in association with a background of pleomorphic adenoma. Carcinoma arising with a background of pleomorphic adenoma is well documented. However, there are rare occurrences of aggressive de novo carcinosarcomas of the parotid that have been reported. Various cell lineages such as the epithelial glandular cells and the stromal spindle cells are involved. We report 23 cases of tumors of the salivary gland comprising 18 cases of carcinoma ex pleomorphic adenoma, four cases of carcinosarcoma of the parotid and one case of benign metastasizing pleomorphic adenoma. The occurrence of various malignancies suggests that this phenomenon is not very uncommon and should be looked for when reporting a mixed tumor.

Original languageEnglish
Pages (from-to)150-154
Number of pages5
JournalIndian Journal of Pathology and Microbiology
Volume52
Issue number2
DOIs
Publication statusPublished - Apr 1 2009

Keywords

  • Carcinoma ex pleomorphic adenoma
  • Carcinosarcoma
  • Malignant mixed tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Microbiology (medical)

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