Specialized diet therapies: Exploration for improving behavior in autism spectrum disorder (asd)

Geir Bjørklund*, Nagwa Abdel Meguid, Maryam Dadar, Lyudmila Pivina, Joanna Kałużna-Czaplińska, Jagoda Jóźwik-Pruska, Jan Aaseth, Max Stanley Chartrand, Mostafa Ibrahim Waly, Yahya Al-Farsi, Md Mostafizur Rahman, Joeri Jan Pen, Salvatore Chirumbolo

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

6 Citations (SciVal)


As a major neurodevelopmental disorder, Autism Spectrum Disorder (ASD) encompasses deficits in communication and repetitive and restricted interests or behaviors in childhood and adolescence. Its etiology may come from either a genetic, epigenetic, neurological, hormonal, or an environmental cause, generating pathways that often altogether play a synergistic role in the development of ASD pathogenesis. Furthermore, the metabolic origin of ASD should be important as well. A balanced diet consisting of the essential and special nutrients, alongside the recommended caloric intake, is highly recommended to promote growth and development that withstand the physiologic and behavioral challenges experienced by ASD children. In this review paper, we evaluated many studies that show a relationship between ASD and diet to develop a better understanding of the specific effects of the overall diet and the individual nutrients required for this population. This review will add a comprehensive update of knowledge in the field and shed light on the possible nutritional deficiencies, metabolic impairments (particularly in the gut microbiome), and malnutrition in individuals with ASD, which should be recognized in order to maintain the improved socio-behavioral habit and physical health.

Original languageEnglish
Pages (from-to)6771-6786
Number of pages16
JournalCurrent Medicinal Chemistry
Issue number40
Publication statusPublished - 2020
Externally publishedYes


  • Autism
  • Casein
  • Diet
  • Environmental stressors
  • Epigenetic stressors
  • Genetic
  • Gluten

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry


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