Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research

Badreldin H. Ali, Gerald Blunden, Musbah O. Tanira, Abderrahim Nemmar

Research output: Contribution to journalArticle

721 Citations (Scopus)

Abstract

Ginger (Zingiber officinale Roscoe, Zingiberacae) is a medicinal plant that has been widely used in Chinese, Ayurvedic and Tibb-Unani herbal medicines all over the world, since antiquity, for a wide array of unrelated ailments that include arthritis, rheumatism, sprains, muscular aches, pains, sore throats, cramps, constipation, indigestion, vomiting, hypertension, dementia, fever, infectious diseases and helminthiasis. Currently, there is a renewed interest in ginger, and several scientific investigations aimed at isolation and identification of active constituents of ginger, scientific verification of its pharmacological actions and of its constituents, and verification of the basis of the use of ginger in some of several diseases and conditions. This article aims at reviewing the most salient recent reports on these investigations. The main pharmacological actions of ginger and compounds isolated therefrom include immuno-modulatory, anti-tumorigenic, anti-inflammatory, anti-apoptotic, anti-hyperglycemic, anti-lipidemic and anti-emetic actions. Ginger is a strong anti-oxidant substance and may either mitigate or prevent generation of free radicals. It is considered a safe herbal medicine with only few and insignificant adverse/side effects. More studies are required in animals and humans on the kinetics of ginger and its constituents and on the effects of their consumption over a long period of time.

Original languageEnglish
Pages (from-to)409-420
Number of pages12
JournalFood and Chemical Toxicology
Volume46
Issue number2
DOIs
Publication statusPublished - Feb 2008

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Keywords

  • Anti-emetic
  • Anti-inflammatory
  • Anti-oxidant
  • Anti-tumorigenic
  • Ginger
  • Gingerols

ASJC Scopus subject areas

  • Food Science
  • Toxicology

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