Some pharmacological studies on Artemisia herba-alba (Asso.) in rabbits and mice

Husnia I. Marrif, B. H. Ali, K. M. Hassan

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

The aqueous extract of Artemisia herba-alba Asso. (Compositae) produced an initial hyperglycaemia which was followed by hypoglycaemia in normoglycaemic and alloxan-treated rabbits and mice. The extract (0.39 g/kg) significantly increased gastrointestinal transit time and the reaction time to thermal stimuli, but had no effect on the activity of alkaline phosphatase or concentrations of creatinine and urea in plasma. Histopathological examination indicated mild hydropic degeneration in hepatocytes and proximal convoluted tubules. The duodenum showed mild oedema of the substantia of the mucosal propria. The plant extract showed weak antimicrobial activity.

Original languageEnglish
Pages (from-to)51-55
Number of pages5
JournalJournal of Ethnopharmacology
Volume49
Issue number1
DOIs
Publication statusPublished - Nov 17 1995

Fingerprint

Artemisia
Edema
Pharmacology
Gastrointestinal Transit
Rabbits
Alloxan
Asteraceae
Plant Extracts
Duodenum
Hypoglycemia
Hyperglycemia
Alkaline Phosphatase
Urea
Hepatocytes
Creatinine
Hot Temperature

Keywords

  • Artemisia herba-alba
  • Extracts
  • Glucose
  • Hypoglycaemic

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

Cite this

Some pharmacological studies on Artemisia herba-alba (Asso.) in rabbits and mice. / Marrif, Husnia I.; Ali, B. H.; Hassan, K. M.

In: Journal of Ethnopharmacology, Vol. 49, No. 1, 17.11.1995, p. 51-55.

Research output: Contribution to journalArticle

@article{b6c8892853814a65a0a6c5fe8b08860d,
title = "Some pharmacological studies on Artemisia herba-alba (Asso.) in rabbits and mice",
abstract = "The aqueous extract of Artemisia herba-alba Asso. (Compositae) produced an initial hyperglycaemia which was followed by hypoglycaemia in normoglycaemic and alloxan-treated rabbits and mice. The extract (0.39 g/kg) significantly increased gastrointestinal transit time and the reaction time to thermal stimuli, but had no effect on the activity of alkaline phosphatase or concentrations of creatinine and urea in plasma. Histopathological examination indicated mild hydropic degeneration in hepatocytes and proximal convoluted tubules. The duodenum showed mild oedema of the substantia of the mucosal propria. The plant extract showed weak antimicrobial activity.",
keywords = "Artemisia herba-alba, Extracts, Glucose, Hypoglycaemic",
author = "Marrif, {Husnia I.} and Ali, {B. H.} and Hassan, {K. M.}",
year = "1995",
month = "11",
day = "17",
doi = "10.1016/0378-8741(95)01302-4",
language = "English",
volume = "49",
pages = "51--55",
journal = "Journal of Ethnopharmacology",
issn = "0378-8741",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Some pharmacological studies on Artemisia herba-alba (Asso.) in rabbits and mice

AU - Marrif, Husnia I.

AU - Ali, B. H.

AU - Hassan, K. M.

PY - 1995/11/17

Y1 - 1995/11/17

N2 - The aqueous extract of Artemisia herba-alba Asso. (Compositae) produced an initial hyperglycaemia which was followed by hypoglycaemia in normoglycaemic and alloxan-treated rabbits and mice. The extract (0.39 g/kg) significantly increased gastrointestinal transit time and the reaction time to thermal stimuli, but had no effect on the activity of alkaline phosphatase or concentrations of creatinine and urea in plasma. Histopathological examination indicated mild hydropic degeneration in hepatocytes and proximal convoluted tubules. The duodenum showed mild oedema of the substantia of the mucosal propria. The plant extract showed weak antimicrobial activity.

AB - The aqueous extract of Artemisia herba-alba Asso. (Compositae) produced an initial hyperglycaemia which was followed by hypoglycaemia in normoglycaemic and alloxan-treated rabbits and mice. The extract (0.39 g/kg) significantly increased gastrointestinal transit time and the reaction time to thermal stimuli, but had no effect on the activity of alkaline phosphatase or concentrations of creatinine and urea in plasma. Histopathological examination indicated mild hydropic degeneration in hepatocytes and proximal convoluted tubules. The duodenum showed mild oedema of the substantia of the mucosal propria. The plant extract showed weak antimicrobial activity.

KW - Artemisia herba-alba

KW - Extracts

KW - Glucose

KW - Hypoglycaemic

UR - http://www.scopus.com/inward/record.url?scp=0029621106&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029621106&partnerID=8YFLogxK

U2 - 10.1016/0378-8741(95)01302-4

DO - 10.1016/0378-8741(95)01302-4

M3 - Article

C2 - 8786657

AN - SCOPUS:0029621106

VL - 49

SP - 51

EP - 55

JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

SN - 0378-8741

IS - 1

ER -