Some pharmacological studies on Artemisia herba-alba (Asso.) in rabbits and mice

Husnia I. Marrif; B. H. Ali; K. M. Hassan

doi:10.1016/0378-8741(95)01302-4

Some pharmacological studies on Artemisia herba-alba (Asso.) in rabbits and mice

Husnia I. Marrif, B. H. Ali^*, K. M. Hassan

^*Corresponding author for this work

Pharmacology & Clinical Pharmacy

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68 Citations (Scopus)

Abstract

The aqueous extract of Artemisia herba-alba Asso. (Compositae) produced an initial hyperglycaemia which was followed by hypoglycaemia in normoglycaemic and alloxan-treated rabbits and mice. The extract (0.39 g/kg) significantly increased gastrointestinal transit time and the reaction time to thermal stimuli, but had no effect on the activity of alkaline phosphatase or concentrations of creatinine and urea in plasma. Histopathological examination indicated mild hydropic degeneration in hepatocytes and proximal convoluted tubules. The duodenum showed mild oedema of the substantia of the mucosal propria. The plant extract showed weak antimicrobial activity.

Original language	English
Pages (from-to)	51-55
Number of pages	5
Journal	Journal of Ethnopharmacology
Volume	49
Issue number	1
DOIs	https://doi.org/10.1016/0378-8741(95)01302-4
Publication status	Published - Nov 17 1995

Keywords

Artemisia herba-alba
Extracts
Glucose
Hypoglycaemic

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.1016/0378-8741(95)01302-4

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abstract = "The aqueous extract of Artemisia herba-alba Asso. (Compositae) produced an initial hyperglycaemia which was followed by hypoglycaemia in normoglycaemic and alloxan-treated rabbits and mice. The extract (0.39 g/kg) significantly increased gastrointestinal transit time and the reaction time to thermal stimuli, but had no effect on the activity of alkaline phosphatase or concentrations of creatinine and urea in plasma. Histopathological examination indicated mild hydropic degeneration in hepatocytes and proximal convoluted tubules. The duodenum showed mild oedema of the substantia of the mucosal propria. The plant extract showed weak antimicrobial activity.",

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AU - Marrif, Husnia I.

AU - Ali, B. H.

AU - Hassan, K. M.

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AB - The aqueous extract of Artemisia herba-alba Asso. (Compositae) produced an initial hyperglycaemia which was followed by hypoglycaemia in normoglycaemic and alloxan-treated rabbits and mice. The extract (0.39 g/kg) significantly increased gastrointestinal transit time and the reaction time to thermal stimuli, but had no effect on the activity of alkaline phosphatase or concentrations of creatinine and urea in plasma. Histopathological examination indicated mild hydropic degeneration in hepatocytes and proximal convoluted tubules. The duodenum showed mild oedema of the substantia of the mucosal propria. The plant extract showed weak antimicrobial activity.

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KW - Glucose

KW - Hypoglycaemic

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Some pharmacological studies on Artemisia herba-alba (Asso.) in rabbits and mice

Abstract

Keywords

ASJC Scopus subject areas

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