Some effects of imidocarb in goats

B. H. Ali, H. B. Suliman, E. B. Abdelsalam

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Clinically normal Nubian goats were given the antiprotozoal drug imidocarb at single intramuscular doses of 6, 12, 18 and 24 mg/kg, and the various clinical, biochemical and pathological manifestations were recorded. At a dose of 6 mg/kg the drug produced no change in any of the parameters studied. At higher doses, the drug produced dependent changes which included increased heart and respitory rates, increased defaecation, urination, depression, incoordination of movement, weakness of the hindlegs, recumbency, and fimally death. Just prior to death, there was a significant decrease in the number of erythrocytes, and in packed cell volume, and haemoglobin concentration. In plasma there was an increase in the activity of aspartate transaminase, urea and creatinine concentrations and inhibition of cholinesterase activity. The main histopathological changes were associated with hepatic and renal damage. Three goats were pretreated with atropine sulphate (1 mg/animal) and after one hour given imidocarb intramuscularly at a dose of 12 mg/kg. The changes were similar but much less severe when compared with those in animals given imidocarb alone at the same dose.

Original languageEnglish
Pages (from-to)477-480
Number of pages4
JournalVeterinary and Human Toxicology
Volume27
Issue number6
Publication statusPublished - 1985

Fingerprint

Imidocarb
imidocarb
Goats
goats
Animals
dosage
Pharmaceutical Preparations
Erythrocyte Count
Defecation
Urination
drugs
Cholinesterases
Ataxia
Aspartate Aminotransferases
Atropine
Cell Size
Urea
Nubian (goat breed)
Creatinine
death

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Toxicology
  • veterinary(all)

Cite this

Ali, B. H., Suliman, H. B., & Abdelsalam, E. B. (1985). Some effects of imidocarb in goats. Veterinary and Human Toxicology, 27(6), 477-480.

Some effects of imidocarb in goats. / Ali, B. H.; Suliman, H. B.; Abdelsalam, E. B.

In: Veterinary and Human Toxicology, Vol. 27, No. 6, 1985, p. 477-480.

Research output: Contribution to journalArticle

Ali, BH, Suliman, HB & Abdelsalam, EB 1985, 'Some effects of imidocarb in goats', Veterinary and Human Toxicology, vol. 27, no. 6, pp. 477-480.
Ali BH, Suliman HB, Abdelsalam EB. Some effects of imidocarb in goats. Veterinary and Human Toxicology. 1985;27(6):477-480.
Ali, B. H. ; Suliman, H. B. ; Abdelsalam, E. B. / Some effects of imidocarb in goats. In: Veterinary and Human Toxicology. 1985 ; Vol. 27, No. 6. pp. 477-480.
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