Slow disease progression and robust therapy-mediated CD4+ T-cell recovery are associated with efficient thymopoiesis during HIV-1 infection

Marie Lise Dion, Rebeka Bordi, Joumana Zeidan, Robert Asaad, Mohammed Rachid Boulassel, Jean Pierre Routy, Micheal M. Lederman, Rafick Pierre Sekaly, Remi Cheynier

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54 Citations (Scopus)

Abstract

In chronic HIV infection, most untreated patients lose naive CD4 + and CD8+ T cells, whereas a minority preserve them despite persistent high viremia. Although antiretroviral therapy (ART)-mediated viral suppression generally results in a rise of naive and total CD4+ T cells, certain patients experience very little or no T-cell reconstitution. High peripheral T-cell activation has been linked to poor clinical outcomes, interfering with previous evaluations of thymic function in disease progression and therapy-mediated T-cell recovery. To circumvent this, we used the sj/βTREC ratio, a robust index of thymopoiesis that is independent of peripheral T-cell proliferation, to evaluate the thymic contribution to the preservation and restoration of naive CD4+ T cells. We show that the loss of naive and total CD4+ T cells is the result of or is exacerbated by a sustained thymic defect, whereas efficient thymopoiesis supports naive and total CD4+ T-cell maintenance in slow progressor patients. In ART-treated patients, CD4+ T-cell recovery was associated with the normalization of thymopoiesis, whereas the thymic defect persisted in aviremic patients who failed to recover CD4+ T-cell counts. Overall, we demonstrate that efficient thymopoiesis is key in the natural maintenance and in therapymediated recovery of naive and total CD4 + T cells.

Original languageEnglish
Pages (from-to)2912-2920
Number of pages9
JournalBlood
Volume109
Issue number7
DOIs
Publication statusPublished - Apr 1 2007

ASJC Scopus subject areas

  • Immunology
  • Biochemistry
  • Hematology
  • Cell Biology

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    Dion, M. L., Bordi, R., Zeidan, J., Asaad, R., Boulassel, M. R., Routy, J. P., Lederman, M. M., Sekaly, R. P., & Cheynier, R. (2007). Slow disease progression and robust therapy-mediated CD4+ T-cell recovery are associated with efficient thymopoiesis during HIV-1 infection. Blood, 109(7), 2912-2920. https://doi.org/10.1182/blood-2006-09-047308