Significance of p53, Bcl-2, and HER-2/neu Protein Expression in Omani Arab Females with Breast Cancer

Mansour Al-Moundhri, V. Nirmala, K. Al-Mawaly, S. Ganguly, I. Burney, A. Rizvi, C. Grant

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Abstract

Racial disparity in the presentation of breast cancer and the outcome of its treatment is well established. However, the causes remain unexplained. The scarcity of reports about the prognostic significance of p53, bcl-2, and HER-2/neu in Arab females with breast cancer has been the impetus to this study. We evaluated the prognostic significance of altered expression of p53, bcl-2, HER-2/neu in Omani Arab females with non-metastatic breast cancer with correlation to other established prognostic factors. We have retrospectively analyzed the immunohistochemical expression of p53, HER-2/neu and bcl-2 in paraffin embedded blocks of 72 females diagnosed with invasive breast cancer between 1992 and 2002. The expression of the above proteins was correlated with other prognostic factors and univariate and multivariate analysis was carried out for all prognostic factors. Overexpression of p53 significantly correlated with younger age (

Original languageEnglish
Pages (from-to)226-231
Number of pages6
JournalPathology and Oncology Research
Volume9
Issue number4
Publication statusPublished - 2003

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Keywords

  • Arab-females
  • Bcl-2
  • Breast cancer
  • HER-2
  • P53

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

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