Abstract
Racial disparity in the presentation of breast cancer and the outcome of its treatment is well established. However, the causes remain unexplained. The scarcity of reports about the prognostic significance of p53, bcl-2, and HER-2/neu in Arab females with breast cancer has been the impetus to this study. We evaluated the prognostic significance of altered expression of p53, bcl-2, HER-2/neu in Omani Arab females with non-metastatic breast cancer with correlation to other established prognostic factors. We have retrospectively analyzed the immunohistochemical expression of p53, HER-2/neu and bcl-2 in paraffin embedded blocks of 72 females diagnosed with invasive breast cancer between 1992 and 2002. The expression of the above proteins was correlated with other prognostic factors and univariate and multivariate analysis was carried out for all prognostic factors. Overexpression of p53 significantly correlated with younger age (
| Original language | English |
|---|---|
| Pages (from-to) | 226-231 |
| Number of pages | 6 |
| Journal | Pathology and Oncology Research |
| Volume | 9 |
| Issue number | 4 |
| Publication status | Published - 2003 |
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Keywords
- Arab-females
- Bcl-2
- Breast cancer
- HER-2
- P53
ASJC Scopus subject areas
- Cancer Research
- Oncology
- Pathology and Forensic Medicine
Cite this
Significance of p53, Bcl-2, and HER-2/neu Protein Expression in Omani Arab Females with Breast Cancer. / Al-Moundhri, Mansour; Nirmala, V.; Al-Mawaly, K.; Ganguly, S.; Burney, I.; Rizvi, A.; Grant, C.
In: Pathology and Oncology Research, Vol. 9, No. 4, 2003, p. 226-231.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Significance of p53, Bcl-2, and HER-2/neu Protein Expression in Omani Arab Females with Breast Cancer
AU - Al-Moundhri, Mansour
AU - Nirmala, V.
AU - Al-Mawaly, K.
AU - Ganguly, S.
AU - Burney, I.
AU - Rizvi, A.
AU - Grant, C.
PY - 2003
Y1 - 2003
N2 - Racial disparity in the presentation of breast cancer and the outcome of its treatment is well established. However, the causes remain unexplained. The scarcity of reports about the prognostic significance of p53, bcl-2, and HER-2/neu in Arab females with breast cancer has been the impetus to this study. We evaluated the prognostic significance of altered expression of p53, bcl-2, HER-2/neu in Omani Arab females with non-metastatic breast cancer with correlation to other established prognostic factors. We have retrospectively analyzed the immunohistochemical expression of p53, HER-2/neu and bcl-2 in paraffin embedded blocks of 72 females diagnosed with invasive breast cancer between 1992 and 2002. The expression of the above proteins was correlated with other prognostic factors and univariate and multivariate analysis was carried out for all prognostic factors. Overexpression of p53 significantly correlated with younger age (
AB - Racial disparity in the presentation of breast cancer and the outcome of its treatment is well established. However, the causes remain unexplained. The scarcity of reports about the prognostic significance of p53, bcl-2, and HER-2/neu in Arab females with breast cancer has been the impetus to this study. We evaluated the prognostic significance of altered expression of p53, bcl-2, HER-2/neu in Omani Arab females with non-metastatic breast cancer with correlation to other established prognostic factors. We have retrospectively analyzed the immunohistochemical expression of p53, HER-2/neu and bcl-2 in paraffin embedded blocks of 72 females diagnosed with invasive breast cancer between 1992 and 2002. The expression of the above proteins was correlated with other prognostic factors and univariate and multivariate analysis was carried out for all prognostic factors. Overexpression of p53 significantly correlated with younger age (
KW - Arab-females
KW - Bcl-2
KW - Breast cancer
KW - HER-2
KW - P53
UR - http://www.scopus.com/inward/record.url?scp=1342322963&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1342322963&partnerID=8YFLogxK
M3 - Article
VL - 9
SP - 226
EP - 231
JO - Pathology and Oncology Research
JF - Pathology and Oncology Research
SN - 1219-4956
IS - 4
ER -