Short synthesis of COX-2 inhibitor inotilone

Saleh Al-Busafi, Muna Al-Belushi, Khalid Al-Muqbali

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

An efficient three-step synthesis of COX-2 inhibitor inotilone from acetaldoxime is described. The structure of inotilone was elucidated via an aldol reaction between 5-methyl-3(2H)-furanone and 3,4-dihydroxybenzaldehyde. This approach describes a convenient pathway to 5-alkyl-3-furanones through isoxazole chemistry.

Original languageEnglish
Pages (from-to)1088-1092
Number of pages5
JournalSynthetic Communications
Volume40
Issue number7
DOIs
Publication statusPublished - Jan 2010

Keywords

  • 3(2H)-furanone
  • COX-2 inhibitor
  • Inotilone
  • Isoxazol ring

ASJC Scopus subject areas

  • Organic Chemistry

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