Short synthesis of COX-2 inhibitor inotilone

Saleh Al-Busafi, Muna Al-Belushi, Khalid Al-Muqbali

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

An efficient three-step synthesis of COX-2 inhibitor inotilone from acetaldoxime is described. The structure of inotilone was elucidated via an aldol reaction between 5-methyl-3(2H)-furanone and 3,4-dihydroxybenzaldehyde. This approach describes a convenient pathway to 5-alkyl-3-furanones through isoxazole chemistry.

Original languageEnglish
Pages (from-to)1088-1092
Number of pages5
JournalSynthetic Communications
Volume40
Issue number7
DOIs
Publication statusPublished - Jan 2010

Fingerprint

Cyclooxygenase 2 Inhibitors
Isoxazoles
inotilone
3-hydroxybutanal
acetaldehyde oxime
protocatechualdehyde

Keywords

  • 3(2H)-furanone
  • COX-2 inhibitor
  • Inotilone
  • Isoxazol ring

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Short synthesis of COX-2 inhibitor inotilone. / Al-Busafi, Saleh; Al-Belushi, Muna; Al-Muqbali, Khalid.

In: Synthetic Communications, Vol. 40, No. 7, 01.2010, p. 1088-1092.

Research output: Contribution to journalArticle

Al-Busafi, Saleh ; Al-Belushi, Muna ; Al-Muqbali, Khalid. / Short synthesis of COX-2 inhibitor inotilone. In: Synthetic Communications. 2010 ; Vol. 40, No. 7. pp. 1088-1092.
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