Short synthesis of COX-2 inhibitor inotilone

Saleh Al-Busafi; Muna Al-Belushi; Khalid Al-Muqbali

doi:10.1080/00397910903047778

Short synthesis of COX-2 inhibitor inotilone

Saleh Al-Busafi^*, Muna Al-Belushi, Khalid Al-Muqbali

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

An efficient three-step synthesis of COX-2 inhibitor inotilone from acetaldoxime is described. The structure of inotilone was elucidated via an aldol reaction between 5-methyl-3(2H)-furanone and 3,4-dihydroxybenzaldehyde. This approach describes a convenient pathway to 5-alkyl-3-furanones through isoxazole chemistry.

Original language	English
Pages (from-to)	1088-1092
Number of pages	5
Journal	Synthetic Communications
Volume	40
Issue number	7
DOIs	https://doi.org/10.1080/00397910903047778
Publication status	Published - Jan 2010

Keywords

3(2H)-furanone
COX-2 inhibitor
Inotilone
Isoxazol ring

ASJC Scopus subject areas

Organic Chemistry

Access to Document

10.1080/00397910903047778

Cite this

@article{e9d989144c3f4682bedb4d2958877f89,

title = "Short synthesis of COX-2 inhibitor inotilone",

abstract = "An efficient three-step synthesis of COX-2 inhibitor inotilone from acetaldoxime is described. The structure of inotilone was elucidated via an aldol reaction between 5-methyl-3(2H)-furanone and 3,4-dihydroxybenzaldehyde. This approach describes a convenient pathway to 5-alkyl-3-furanones through isoxazole chemistry.",

keywords = "3(2H)-furanone, COX-2 inhibitor, Inotilone, Isoxazol ring",

author = "Saleh Al-Busafi and Muna Al-Belushi and Khalid Al-Muqbali",

note = "Funding Information: We acknowledge, with thanks, the financial support from the Sultan Qaboos University. The authors are also grateful to Professor M. Khan (Sultan Qaboos University) for extremely helpful discussions.",

year = "2010",

month = jan,

doi = "10.1080/00397910903047778",

language = "English",

volume = "40",

pages = "1088--1092",

journal = "Synthetic Communications",

issn = "0039-7911",

publisher = "Taylor and Francis Ltd.",

number = "7",

}

TY - JOUR

T1 - Short synthesis of COX-2 inhibitor inotilone

AU - Al-Busafi, Saleh

AU - Al-Belushi, Muna

AU - Al-Muqbali, Khalid

N1 - Funding Information: We acknowledge, with thanks, the financial support from the Sultan Qaboos University. The authors are also grateful to Professor M. Khan (Sultan Qaboos University) for extremely helpful discussions.

PY - 2010/1

Y1 - 2010/1

N2 - An efficient three-step synthesis of COX-2 inhibitor inotilone from acetaldoxime is described. The structure of inotilone was elucidated via an aldol reaction between 5-methyl-3(2H)-furanone and 3,4-dihydroxybenzaldehyde. This approach describes a convenient pathway to 5-alkyl-3-furanones through isoxazole chemistry.

AB - An efficient three-step synthesis of COX-2 inhibitor inotilone from acetaldoxime is described. The structure of inotilone was elucidated via an aldol reaction between 5-methyl-3(2H)-furanone and 3,4-dihydroxybenzaldehyde. This approach describes a convenient pathway to 5-alkyl-3-furanones through isoxazole chemistry.

KW - 3(2H)-furanone

KW - COX-2 inhibitor

KW - Inotilone

KW - Isoxazol ring

UR - http://www.scopus.com/inward/record.url?scp=77749304338&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77749304338&partnerID=8YFLogxK

U2 - 10.1080/00397910903047778

DO - 10.1080/00397910903047778

M3 - Article

AN - SCOPUS:77749304338

SN - 0039-7911

VL - 40

SP - 1088

EP - 1092

JO - Synthetic Communications

JF - Synthetic Communications

IS - 7

ER -

Short synthesis of COX-2 inhibitor inotilone

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this