Sesame oil exhibits synergistic effect with anti-diabetic medication in patients with type 2 diabetes mellitus

Devarajan Sankar, Amanat Ali, Ganapathy Sambandam, Ramakrishna Rao

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background & aims: Recently, studies have reported that sesame oil lowered blood pressure and improved antioxidant status in hypertensive and diabetic-hypertensive patients. The aim of this study was to evaluate the effectiveness of sesame oil with anti-diabetic (glibenclamide) medication as combination therapy in mild-to moderate diabetic patients. Methods: This open label study included sixty type 2 diabetes mellitus patients divided into 3 groups, receiving sesame oil (n = 18), 5 mg/day (single dose) of glibenclamide (n = 20), or their combination (n = 22). The patients were supplied with sesame oil [BNB Sesame oil TM] except glibenclamide group, and instructed to use approximately 35 g of oil/day/person for cooking, or salad preparation for 60 days. 12 h-fasting venous blood samples were collected at baseline (0 day) and after 60 days of the experiment for various biochemical analysis. Results: As compared with sesame oil and glibenclamide alone, combination therapy showed an improved anti-hyperglycemic effect with 36% reduction of glucose (P <0.001 vs before treatment, P <0.01 vs sesame oil monotherapy, P <0.05 vs glibenclamide monotherapy) and 43% reduction of HbA 1c (P <0.001 vs before treatment, P <0.01 vs sesame oil monotherapy, P <0.05 vs glibenclamide monotherapy) at the end point. Significant reductions in the plasma TC, LDL-C and TG levels were noted in sesame oil (20%, 33.8% and 14% respectively vs before treatment) or combination therapies (22%, 38% and 15% respectively vs before treatment). Plasma HDL-C was significantly improved in sesame oil (15.7% vs before treatment) or combination therapies (17% before treatment). Significant (P <0.001) improvement was observed in the activities of enzymatic and non-enzymatic antioxidants in patients treated with sesame oil and its combination with glibenclamide. Conclusions: Sesame oil exhibited synergistic effect with glibenclamide and can provide a safe and effective option for the drug combination that may be very useful in clinical practice for the effective improvement of hyperglycemia.

Original languageEnglish
Pages (from-to)351-358
Number of pages8
JournalClinical Nutrition
Volume30
Issue number3
DOIs
Publication statusPublished - Jun 2011

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Sesame Oil
Type 2 Diabetes Mellitus
Glyburide
Therapeutics
Antioxidants
Cooking
Drug Combinations
Hyperglycemia
Fasting

Keywords

  • Antioxidants
  • Glibenclamide
  • Glucose
  • HbA1c
  • Lipid profile
  • Sesame oil
  • Type 2 diabetes

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Nutrition and Dietetics

Cite this

Sesame oil exhibits synergistic effect with anti-diabetic medication in patients with type 2 diabetes mellitus. / Sankar, Devarajan; Ali, Amanat; Sambandam, Ganapathy; Rao, Ramakrishna.

In: Clinical Nutrition, Vol. 30, No. 3, 06.2011, p. 351-358.

Research output: Contribution to journalArticle

Sankar, Devarajan ; Ali, Amanat ; Sambandam, Ganapathy ; Rao, Ramakrishna. / Sesame oil exhibits synergistic effect with anti-diabetic medication in patients with type 2 diabetes mellitus. In: Clinical Nutrition. 2011 ; Vol. 30, No. 3. pp. 351-358.
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N2 - Background & aims: Recently, studies have reported that sesame oil lowered blood pressure and improved antioxidant status in hypertensive and diabetic-hypertensive patients. The aim of this study was to evaluate the effectiveness of sesame oil with anti-diabetic (glibenclamide) medication as combination therapy in mild-to moderate diabetic patients. Methods: This open label study included sixty type 2 diabetes mellitus patients divided into 3 groups, receiving sesame oil (n = 18), 5 mg/day (single dose) of glibenclamide (n = 20), or their combination (n = 22). The patients were supplied with sesame oil [BNB Sesame oil TM] except glibenclamide group, and instructed to use approximately 35 g of oil/day/person for cooking, or salad preparation for 60 days. 12 h-fasting venous blood samples were collected at baseline (0 day) and after 60 days of the experiment for various biochemical analysis. Results: As compared with sesame oil and glibenclamide alone, combination therapy showed an improved anti-hyperglycemic effect with 36% reduction of glucose (P <0.001 vs before treatment, P <0.01 vs sesame oil monotherapy, P <0.05 vs glibenclamide monotherapy) and 43% reduction of HbA 1c (P <0.001 vs before treatment, P <0.01 vs sesame oil monotherapy, P <0.05 vs glibenclamide monotherapy) at the end point. Significant reductions in the plasma TC, LDL-C and TG levels were noted in sesame oil (20%, 33.8% and 14% respectively vs before treatment) or combination therapies (22%, 38% and 15% respectively vs before treatment). Plasma HDL-C was significantly improved in sesame oil (15.7% vs before treatment) or combination therapies (17% before treatment). Significant (P <0.001) improvement was observed in the activities of enzymatic and non-enzymatic antioxidants in patients treated with sesame oil and its combination with glibenclamide. Conclusions: Sesame oil exhibited synergistic effect with glibenclamide and can provide a safe and effective option for the drug combination that may be very useful in clinical practice for the effective improvement of hyperglycemia.

AB - Background & aims: Recently, studies have reported that sesame oil lowered blood pressure and improved antioxidant status in hypertensive and diabetic-hypertensive patients. The aim of this study was to evaluate the effectiveness of sesame oil with anti-diabetic (glibenclamide) medication as combination therapy in mild-to moderate diabetic patients. Methods: This open label study included sixty type 2 diabetes mellitus patients divided into 3 groups, receiving sesame oil (n = 18), 5 mg/day (single dose) of glibenclamide (n = 20), or their combination (n = 22). The patients were supplied with sesame oil [BNB Sesame oil TM] except glibenclamide group, and instructed to use approximately 35 g of oil/day/person for cooking, or salad preparation for 60 days. 12 h-fasting venous blood samples were collected at baseline (0 day) and after 60 days of the experiment for various biochemical analysis. Results: As compared with sesame oil and glibenclamide alone, combination therapy showed an improved anti-hyperglycemic effect with 36% reduction of glucose (P <0.001 vs before treatment, P <0.01 vs sesame oil monotherapy, P <0.05 vs glibenclamide monotherapy) and 43% reduction of HbA 1c (P <0.001 vs before treatment, P <0.01 vs sesame oil monotherapy, P <0.05 vs glibenclamide monotherapy) at the end point. Significant reductions in the plasma TC, LDL-C and TG levels were noted in sesame oil (20%, 33.8% and 14% respectively vs before treatment) or combination therapies (22%, 38% and 15% respectively vs before treatment). Plasma HDL-C was significantly improved in sesame oil (15.7% vs before treatment) or combination therapies (17% before treatment). Significant (P <0.001) improvement was observed in the activities of enzymatic and non-enzymatic antioxidants in patients treated with sesame oil and its combination with glibenclamide. Conclusions: Sesame oil exhibited synergistic effect with glibenclamide and can provide a safe and effective option for the drug combination that may be very useful in clinical practice for the effective improvement of hyperglycemia.

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