Serum arylsulfatase A assay in metachromatic leukodystrophy: An experience in a neuropsychiatric set-up

Rita Christopher*, C. P. Narayanan, G. R. Arunodaya, K. Taranath Shetty

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Metachromatic leukodystrophy is a lysosomal disease caused mainly by a deficiency of the enzyme arylsulfatase A. The assay of arylsulfatase A in the serum provides a fast and easy method for the confirmatory diagnosis of this disorder. Serum arylsulfatase A was estimated in 52 normal healthy control subjects and 269 patients with symptoms of cerebral white matter disease in order to diagnose and confirm metachromatic leukodystrophy. A total of eight cases of metachromatic leukodystrophy with a low serum arylsulfatase A was detected, of which three cases were of the late-infantile type, four cases the juvenile type and only one case the adult type.

Original languageEnglish
Pages (from-to)89-92
Number of pages4
JournalIndian Journal of Clinical Biochemistry
Volume10
Issue number2
DOIs
Publication statusPublished - Jul 1995

Keywords

  • Metachromatic leukodystrophy detection
  • serum arylsulfatase A

ASJC Scopus subject areas

  • Clinical Biochemistry

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