TY - JOUR
T1 - Sero-prevalence of Helicobacter pylori infection among asymptomatic healthy Omani blood donors
AU - Al-Balushi, Mohammed Said
AU - Al-Busaidi, Juma Z.
AU - Al-Daihani, Muna S.
AU - Shafeeq, Mohammed O.
AU - Hasson, Sidgi S.
N1 - Funding Information:
*Corresponding author: Dr. SidgiHasson, Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box 35, Code 123, Muscat, Oman. Tel: +968 24143549 E-mail: shyahasson@squ.edu.om Foundation Project: Financially supported by the departmental-internal fund support, Sultan Qaboos University (Grant No./MICIMM/IMM/04/2012).
Funding Information:
Funding for this project was provided by the departmental-internal fund support, Sultan Qaboos University (Grant No./MICIMM/IMM/04/2012). The authors would like to extend deep thanks to the Sultan Qaboos University Hospital for using their facilities-support to carry out this investigation. Moreover, the authors also would like to thanks the HIS staff for their technical support.
PY - 2013/4
Y1 - 2013/4
N2 - Objective: To investigate the prevalence of Helicobacter pylori (H. pylori) infection, a cross-sectional epidemiological study, based on the age and gender-specific seroprevalence of H. pylori antibodies in asymptomatic healthy Omani blood donors attending the SQUH blood bank. Methods: Analysis of the sera from 133 apparently healthy subjects, based on the serological determination of the IgM, IgG and IgA antibodies against H. pylori, was carried out using a commercially available kit ELISA (NovaLisa, NovaTec, Germany). While the presence of H. pylori-specific IgG antibodies is the marker for a " "chronic. infection with this pathogen. Therefore, there was no indicator of the time of acquisition of the infection. However, the H. pylori-specific IgM antibody was a more specific marker for a recently acquired infection with H. pylori. Results: Of the 133 subjects, there were 100 (74. %) males and 33 (26. %) females. The age range was 15 to 50 years with a mean of 25.75. ±3.75 years. The overall prevalence of H. pylori infection in our study was 69.5. %. The overall seroprevalence was found to be increased 69. %-86. % with age. Subjects between 15. -20 years of age showed 71. % seroprevalence, while those between 21. -40 years showed gradual increase (63. %-70. %) with age and reached up to 87. % in subjects between 41. -50 years of age. A significant inverse association was found between sex and age groups. This is when each age group was examined individually; a higher positive percentage of H. pylori antibodies increasing with age was seen in males between 21. -40 years of age group in comparison to the females of the same age group. Male subjects with age group between 21 to 40 years were found to have a significant seropositivity compared to the female subjects within the same group. This may reflect how frequent were the male subjects being exposed to the outer environment and their conduct than the females in this society like Oman. Conclusions: The seropositivity of H. pylori is moderately higher between ages of 21 to 30 more than any other age group.
AB - Objective: To investigate the prevalence of Helicobacter pylori (H. pylori) infection, a cross-sectional epidemiological study, based on the age and gender-specific seroprevalence of H. pylori antibodies in asymptomatic healthy Omani blood donors attending the SQUH blood bank. Methods: Analysis of the sera from 133 apparently healthy subjects, based on the serological determination of the IgM, IgG and IgA antibodies against H. pylori, was carried out using a commercially available kit ELISA (NovaLisa, NovaTec, Germany). While the presence of H. pylori-specific IgG antibodies is the marker for a " "chronic. infection with this pathogen. Therefore, there was no indicator of the time of acquisition of the infection. However, the H. pylori-specific IgM antibody was a more specific marker for a recently acquired infection with H. pylori. Results: Of the 133 subjects, there were 100 (74. %) males and 33 (26. %) females. The age range was 15 to 50 years with a mean of 25.75. ±3.75 years. The overall prevalence of H. pylori infection in our study was 69.5. %. The overall seroprevalence was found to be increased 69. %-86. % with age. Subjects between 15. -20 years of age showed 71. % seroprevalence, while those between 21. -40 years showed gradual increase (63. %-70. %) with age and reached up to 87. % in subjects between 41. -50 years of age. A significant inverse association was found between sex and age groups. This is when each age group was examined individually; a higher positive percentage of H. pylori antibodies increasing with age was seen in males between 21. -40 years of age group in comparison to the females of the same age group. Male subjects with age group between 21 to 40 years were found to have a significant seropositivity compared to the female subjects within the same group. This may reflect how frequent were the male subjects being exposed to the outer environment and their conduct than the females in this society like Oman. Conclusions: The seropositivity of H. pylori is moderately higher between ages of 21 to 30 more than any other age group.
KW - Blood donors
KW - Helicobacter pylori
KW - Oman
KW - SQU
KW - Seropositivity
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U2 - 10.1016/S2222-1808(13)60059-6
DO - 10.1016/S2222-1808(13)60059-6
M3 - Article
AN - SCOPUS:84875058253
SN - 2222-1808
VL - 3
SP - 146
EP - 149
JO - Asian Pacific Journal of Tropical Disease
JF - Asian Pacific Journal of Tropical Disease
IS - 2
ER -
