Abstract
Ten cases of psoriasis were studied to see the pattern of histological resolution and to evaluate clinico-histological correlation in psoriasis following weekly methotrexate therapy. Five sequential biopsies were taken in each patient. Scaling was first to regress followed by induration and erythema in 18, 26 and 35 days, respectively. Uniform granular layer appeared in 4 days, stratum corneum became orthokeratotic in 7 days, mitotic activity got restricted to basal layer in 7 days and rete ridges elongation was reduced to half in 11 days. Mild acanthosis, cellular infiltrate and vascular dilatation persisted even after full clinical regression. Interestingly, 5 out of 10 biopsies revealed increase in cellular infiltrate and oedema after first methotrexate pulse.
| Original language | English |
|---|---|
| Pages (from-to) | 284-287 |
| Number of pages | 4 |
| Journal | Indian Journal of Dermatology, Venereology and Leprology |
| Volume | 61 |
| Issue number | 5 |
| Publication status | Published - 1995 |
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Keywords
- histopathology
- methotrexate
- psoriasis
ASJC Scopus subject areas
- Dermatology
Cite this
Sequential clinico-histological studies in psoriasis following methotrexate therapy. / Talwar, S.; Tiwari, V. D.; Lakhtakia, R.; Panvelkar, V.
In: Indian Journal of Dermatology, Venereology and Leprology, Vol. 61, No. 5, 1995, p. 284-287.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sequential clinico-histological studies in psoriasis following methotrexate therapy
AU - Talwar, S.
AU - Tiwari, V. D.
AU - Lakhtakia, R.
AU - Panvelkar, V.
PY - 1995
Y1 - 1995
N2 - Ten cases of psoriasis were studied to see the pattern of histological resolution and to evaluate clinico-histological correlation in psoriasis following weekly methotrexate therapy. Five sequential biopsies were taken in each patient. Scaling was first to regress followed by induration and erythema in 18, 26 and 35 days, respectively. Uniform granular layer appeared in 4 days, stratum corneum became orthokeratotic in 7 days, mitotic activity got restricted to basal layer in 7 days and rete ridges elongation was reduced to half in 11 days. Mild acanthosis, cellular infiltrate and vascular dilatation persisted even after full clinical regression. Interestingly, 5 out of 10 biopsies revealed increase in cellular infiltrate and oedema after first methotrexate pulse.
AB - Ten cases of psoriasis were studied to see the pattern of histological resolution and to evaluate clinico-histological correlation in psoriasis following weekly methotrexate therapy. Five sequential biopsies were taken in each patient. Scaling was first to regress followed by induration and erythema in 18, 26 and 35 days, respectively. Uniform granular layer appeared in 4 days, stratum corneum became orthokeratotic in 7 days, mitotic activity got restricted to basal layer in 7 days and rete ridges elongation was reduced to half in 11 days. Mild acanthosis, cellular infiltrate and vascular dilatation persisted even after full clinical regression. Interestingly, 5 out of 10 biopsies revealed increase in cellular infiltrate and oedema after first methotrexate pulse.
KW - histopathology
KW - methotrexate
KW - psoriasis
UR - http://www.scopus.com/inward/record.url?scp=0029558182&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029558182&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0029558182
VL - 61
SP - 284
EP - 287
JO - Indian Journal of Dermatology, Venereology and Leprology
JF - Indian Journal of Dermatology, Venereology and Leprology
SN - 0378-6323
IS - 5
ER -