Abstract
Selenium in the form of sodium selenite (SSE) is an essential micronutrient which known to possess antioxidant and anticancer properties. This study emphasizes the role of selenium on oxidative stress in experimental rats with N-diethylnitrosamine (DEN) initiated and 2-acetylaminofluorene (2-AAF) promoted multistage hepatocellular carcinogenesis (HCC). Rats were divided randomly into six groups: negative control, positive control (DEN+2-AAF), preventive group (pre-SEE 4 weeks+DEN), preventive control (respective control for preventive group), therapeutic group (DEN+post-SSE 12 weeks) and therapeutic control (respective control for therapeutic group). SSE (4 mg L -1) was given to animals before initiation and during promotion phase of HCC. The levels of total protein (TP), conjugated diens (CD), malondialdehyde (MDA), fluorescent pigment (FP), antioxidant activity (AOA) and DNA damage were measured. Supplementation of SSE before the initiation phase of carcinogenicity significantly increased TP and AOA level (p
| Original language | English |
|---|---|
| Pages (from-to) | 1055-1060 |
| Number of pages | 6 |
| Journal | Pakistan Journal of Biological Sciences |
| Volume | 14 |
| Issue number | 23 |
| DOIs | |
| Publication status | Published - 2011 |
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Keywords
- 2-acetylaminofluorene
- Antioxidant
- Diethylnitrosamine
- Liver cancer
- Sodium selenite
ASJC Scopus subject areas
- Agronomy and Crop Science
Cite this
Selenium supplementation reduced oxidative stress in diethylnitrosamine-induced hepatocellular carcinoma in rats. / Mohamed, Jamaludin; Wei, Wong Lik; Husin, Nazratun Nafizah Akhtar; Alwahaibi, Nasar Y.; Budin, Siti Balkis.
In: Pakistan Journal of Biological Sciences, Vol. 14, No. 23, 2011, p. 1055-1060.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Selenium supplementation reduced oxidative stress in diethylnitrosamine-induced hepatocellular carcinoma in rats
AU - Mohamed, Jamaludin
AU - Wei, Wong Lik
AU - Husin, Nazratun Nafizah Akhtar
AU - Alwahaibi, Nasar Y.
AU - Budin, Siti Balkis
PY - 2011
Y1 - 2011
N2 - Selenium in the form of sodium selenite (SSE) is an essential micronutrient which known to possess antioxidant and anticancer properties. This study emphasizes the role of selenium on oxidative stress in experimental rats with N-diethylnitrosamine (DEN) initiated and 2-acetylaminofluorene (2-AAF) promoted multistage hepatocellular carcinogenesis (HCC). Rats were divided randomly into six groups: negative control, positive control (DEN+2-AAF), preventive group (pre-SEE 4 weeks+DEN), preventive control (respective control for preventive group), therapeutic group (DEN+post-SSE 12 weeks) and therapeutic control (respective control for therapeutic group). SSE (4 mg L -1) was given to animals before initiation and during promotion phase of HCC. The levels of total protein (TP), conjugated diens (CD), malondialdehyde (MDA), fluorescent pigment (FP), antioxidant activity (AOA) and DNA damage were measured. Supplementation of SSE before the initiation phase of carcinogenicity significantly increased TP and AOA level (p
AB - Selenium in the form of sodium selenite (SSE) is an essential micronutrient which known to possess antioxidant and anticancer properties. This study emphasizes the role of selenium on oxidative stress in experimental rats with N-diethylnitrosamine (DEN) initiated and 2-acetylaminofluorene (2-AAF) promoted multistage hepatocellular carcinogenesis (HCC). Rats were divided randomly into six groups: negative control, positive control (DEN+2-AAF), preventive group (pre-SEE 4 weeks+DEN), preventive control (respective control for preventive group), therapeutic group (DEN+post-SSE 12 weeks) and therapeutic control (respective control for therapeutic group). SSE (4 mg L -1) was given to animals before initiation and during promotion phase of HCC. The levels of total protein (TP), conjugated diens (CD), malondialdehyde (MDA), fluorescent pigment (FP), antioxidant activity (AOA) and DNA damage were measured. Supplementation of SSE before the initiation phase of carcinogenicity significantly increased TP and AOA level (p
KW - 2-acetylaminofluorene
KW - Antioxidant
KW - Diethylnitrosamine
KW - Liver cancer
KW - Sodium selenite
UR - http://www.scopus.com/inward/record.url?scp=82855161613&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=82855161613&partnerID=8YFLogxK
U2 - 10.3923/pjbs.2011.1055.1060
DO - 10.3923/pjbs.2011.1055.1060
M3 - Article
VL - 14
SP - 1055
EP - 1060
JO - Pakistan Journal of Biological Sciences
JF - Pakistan Journal of Biological Sciences
SN - 1028-8880
IS - 23
ER -