Selenium supplementation reduced oxidative stress in diethylnitrosamine-induced hepatocellular carcinoma in rats

Jamaludin Mohamed, Wong Lik Wei, Nazratun Nafizah Akhtar Husin, Nasar Y. Alwahaibi, Siti Balkis Budin

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Selenium in the form of sodium selenite (SSE) is an essential micronutrient which known to possess antioxidant and anticancer properties. This study emphasizes the role of selenium on oxidative stress in experimental rats with N-diethylnitrosamine (DEN) initiated and 2-acetylaminofluorene (2-AAF) promoted multistage hepatocellular carcinogenesis (HCC). Rats were divided randomly into six groups: negative control, positive control (DEN+2-AAF), preventive group (pre-SEE 4 weeks+DEN), preventive control (respective control for preventive group), therapeutic group (DEN+post-SSE 12 weeks) and therapeutic control (respective control for therapeutic group). SSE (4 mg L -1) was given to animals before initiation and during promotion phase of HCC. The levels of total protein (TP), conjugated diens (CD), malondialdehyde (MDA), fluorescent pigment (FP), antioxidant activity (AOA) and DNA damage were measured. Supplementation of SSE before the initiation phase of carcinogenicity significantly increased TP and AOA level (p

Original languageEnglish
Pages (from-to)1055-1060
Number of pages6
JournalPakistan Journal of Biological Sciences
Volume14
Issue number23
DOIs
Publication statusPublished - 2011

Keywords

  • 2-acetylaminofluorene
  • Antioxidant
  • Diethylnitrosamine
  • Liver cancer
  • Sodium selenite

ASJC Scopus subject areas

  • Agronomy and Crop Science

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