Sarcoroseolides A-D, four undescribed cembranoids from the Red Sea soft coral Sarcophyton roseum

Mohammed M.A. Ahmed, Mohamed A. Albadry, Ehab A. Ragab*, Elsayed M. El-Ghaly, Said K. Ismail, Zulfiqar Ali, Shabana I. Khan, Amar G. Chittiboyina, Ikhlas A. Khan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Four undescribed cembranoids, sarcoroseolides A-D (1-4) along with nine reported related cembranoids (5-13) were isolated from the soft coral Sarcophyton roseum. The chemical structures of sarcoroseolides A-D were elucidated by extensive 1 D and 2 D NMR as well as HR-ESIMS spectroscopic data. Moreover, the geometric and absolute configurations were assigned by the modified Mosher’s method and/or NOESY experiments. The extract and the isolated metabolites were evaluated for their potential anti-inflammatory and cytotoxic activities.

Original languageEnglish
Pages (from-to)1842-1850
Number of pages9
JournalNatural Product Research
Volume36
Issue number7
DOIs
Publication statusPublished - 2022
Externally publishedYes

Keywords

  • Sarcophyton roseum
  • Soft coral
  • cembranoids
  • sarcoroseolides A-D

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

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