TY - JOUR
T1 - Safety warning for chadox1 ncov-19 vaccine in patients with sickle cell disease
AU - Alkindi, S.
AU - Elsadek, R. A.
AU - Pathare, A. V.
N1 - Publisher Copyright:
© 2021 Universita Cattolica del Sacro Cuore. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Vaccines against acute respiratory syndrome Coronavirus 2(SARS-CoV2) are critical weapons to control the spread of the deadly Coronavirus 2019(COVId-19) virus worldwide. Although these vaccines are generally safe, their widespread use has produced reports of rare complications, including vaccine-induced immune thrombotic thrombocytopenia (VIITT), particularly in connection with ChAdOx1 nCov-19. We have identified three cases of sickle cell disease (SCD) experiencing a severe vaso-occlusive crisis (VOC) shortly after the vaccine. Despite being stable for a long time, they had fever with tachycardia, along with a significant rise in WBC, liver enzymes, particularly alkaline phosphate, with a remarkable drop in hemoglobin, and platelets and one of them had probably a fatal TTP like syndrome. Given these findings, physicians and patients should exercise caution when taking this type of vaccine and be aware of these safety concerns.
AB - Vaccines against acute respiratory syndrome Coronavirus 2(SARS-CoV2) are critical weapons to control the spread of the deadly Coronavirus 2019(COVId-19) virus worldwide. Although these vaccines are generally safe, their widespread use has produced reports of rare complications, including vaccine-induced immune thrombotic thrombocytopenia (VIITT), particularly in connection with ChAdOx1 nCov-19. We have identified three cases of sickle cell disease (SCD) experiencing a severe vaso-occlusive crisis (VOC) shortly after the vaccine. Despite being stable for a long time, they had fever with tachycardia, along with a significant rise in WBC, liver enzymes, particularly alkaline phosphate, with a remarkable drop in hemoglobin, and platelets and one of them had probably a fatal TTP like syndrome. Given these findings, physicians and patients should exercise caution when taking this type of vaccine and be aware of these safety concerns.
KW - ChAdOx1 nCov-19 vaccine
KW - SARS-CoV2
KW - Sickle cell disease
KW - Vaccine-induced immune thrombotic thrombocytopenia
KW - Vaso-occlusive crisis
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U2 - 10.4084/MJHID.2021.059
DO - 10.4084/MJHID.2021.059
M3 - Article
C2 - 34527211
AN - SCOPUS:85115134873
SN - 2035-3006
VL - 13
JO - Mediterranean Journal of Hematology and Infectious Diseases
JF - Mediterranean Journal of Hematology and Infectious Diseases
IS - 1
M1 - e2021059
ER -