Role of MicroRNA in proliferation phase of wound healing

Amro M. Soliman, Srijit Das, Norzana Abd Ghafar, Seong Lin Teoh*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

22 Citations (Scopus)

Abstract

Wound healing is a complex biological process that is generally composed of four phases: hemostasis, inflammation, proliferation, and remodeling. The proliferation phase is crucial for effective healing compared to other phases. Many critical events occur during this phase, i.e., migration of fibroblasts, re-epithelialization, angiogenesis and wound contraction. Chronic wounds are common and are considered a major public health problem. Therefore, there is the increasing need to discover new therapeutic strategies. MicroRNA (miRNA) research in the field of wound healing is in its early phase, but the knowledge of the recent discoveries is essential for developing effective therapies for the treatment of chronic wounds. In this review, we focused on recently discovered miRNAs which are involved in the proliferation phase of wound healing in the past few years and their role in wound healing.

Original languageEnglish
Article number38
JournalFrontiers in Genetics
Volume9
Issue numberFEB
DOIs
Publication statusPublished - Feb 14 2018
Externally publishedYes

Keywords

  • Angiogenesis
  • Chronic wound
  • Healing
  • MicroRNA
  • Re-epithelialization

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Genetics(clinical)

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