TY - JOUR
T1 - Role of MicroRNA in proliferation phase of wound healing
AU - Soliman, Amro M.
AU - Das, Srijit
AU - Abd Ghafar, Norzana
AU - Teoh, Seong Lin
N1 - Publisher Copyright:
© 2018 Soliman, Das, Abd Ghafar and Teoh.
PY - 2018/2/14
Y1 - 2018/2/14
N2 - Wound healing is a complex biological process that is generally composed of four phases: hemostasis, inflammation, proliferation, and remodeling. The proliferation phase is crucial for effective healing compared to other phases. Many critical events occur during this phase, i.e., migration of fibroblasts, re-epithelialization, angiogenesis and wound contraction. Chronic wounds are common and are considered a major public health problem. Therefore, there is the increasing need to discover new therapeutic strategies. MicroRNA (miRNA) research in the field of wound healing is in its early phase, but the knowledge of the recent discoveries is essential for developing effective therapies for the treatment of chronic wounds. In this review, we focused on recently discovered miRNAs which are involved in the proliferation phase of wound healing in the past few years and their role in wound healing.
AB - Wound healing is a complex biological process that is generally composed of four phases: hemostasis, inflammation, proliferation, and remodeling. The proliferation phase is crucial for effective healing compared to other phases. Many critical events occur during this phase, i.e., migration of fibroblasts, re-epithelialization, angiogenesis and wound contraction. Chronic wounds are common and are considered a major public health problem. Therefore, there is the increasing need to discover new therapeutic strategies. MicroRNA (miRNA) research in the field of wound healing is in its early phase, but the knowledge of the recent discoveries is essential for developing effective therapies for the treatment of chronic wounds. In this review, we focused on recently discovered miRNAs which are involved in the proliferation phase of wound healing in the past few years and their role in wound healing.
KW - Angiogenesis
KW - Chronic wound
KW - Healing
KW - MicroRNA
KW - Re-epithelialization
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U2 - 10.3389/fgene.2018.00038
DO - 10.3389/fgene.2018.00038
M3 - Review article
AN - SCOPUS:85042452137
SN - 1664-8021
VL - 9
JO - Frontiers in Genetics
JF - Frontiers in Genetics
IS - FEB
M1 - 38
ER -