Role of adhatoda vasica (L.) nees leaf extract in the prevention of aflatoxin-induced toxicity in Wistar rats

Rajendran Brinda, Selvaraj Vijayanandraj, Doraiswamy Uma, Dorairaj Malathi, Vaikuntavasan Paranidharan, Rethinasamy Velazhahan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Background: Aflatoxin contamination of various foodstuffs and agricultural commodities is a major problem worldwide. Several strategies have been reported for the detoxification of aflatoxins in contaminated foods and feeds, but all these methods have their own shortcomings. Traditional medicinal plants are potential sources of aflatoxin-detoxifying compounds. In this study a spray-dried formulation of Adhatoda vasica (L.) Nees leaf extract was prepared and its chemopreventive effect on aflatoxin B1 (AFB1)-induced biochemical changes in the liver and serum of Wistar rats was investigated. Results: Administration of AFB1 (1.5 mg kg-1 body weight (BW) intraperitoneally) to rats significantly reduced the activities of superoxide dismutase and catalase in liver tissues and increased the activities of aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase and the levels of very-low-density lipoprotein, low-density lipoprotein and cholesterol in blood serum. However, pre-feeding of rats with A. vasica formulation (500 mg kg-1 BW for 7 days) protected the animals from AFB1-induced biochemical changes during subsequent exposure to AFB1. Conclusion: Pre-feeding of rats with A. vasica formulation counteracted the hepatic dysfunction induced by subsequent treatment with AFB1. This formulated A. vasica extract offers a biologically safe alternative to detoxify aflatoxin and has huge potential to be used in the poultry industry to reduce aflatoxicosis.

Original languageEnglish
Pages (from-to)2743-2748
Number of pages6
JournalJournal of the Science of Food and Agriculture
Issue number11
Publication statusPublished - Aug 30 2013
Externally publishedYes


  • Adhatoda vasica
  • Aflatoxin
  • Chemoprevention
  • Detoxification
  • Medicinal plants

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Agronomy and Crop Science
  • Nutrition and Dietetics


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