Rituximab for refractory autoimmune hepatitis: A case report

Said A. Al-Busafi, René P. Michel, Marc Deschenes

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Auto-immune hepatitis (AIH) is a chronic progressive hepatitis of unknown aetiology whose clinical presentation ranges from asymptomatic to fulminant hepatic failure. Corticosteroids and azathioprine, which are considered standard therapy for AIH, may, however, be associated with treatment failures and toxicities. Among the alternative medications under investigation, rituximab, used to treat successfully various auto-immune disorders, has fewer side effects. We report herein the case of a 68-year-old woman who developed AIH with worsening clinical, laboratory and histological features despite high-dose prednisone. On rituximab, the patient showed rapid and dramatic clinical improvement, suggesting a therapeutic role for this medication in severe AIH. Indeed, prospective controlled studies are needed to assess and validate this role.

Original languageEnglish
Pages (from-to)135-138
Number of pages4
JournalArab Journal of Gastroenterology
Volume14
Issue number3
DOIs
Publication statusPublished - Sep 2013

Fingerprint

Autoimmune Hepatitis
Hepatitis
Acute Liver Failure
Immune System Diseases
Azathioprine
Chronic Hepatitis
Prednisone
Treatment Failure
Adrenal Cortex Hormones
Prospective Studies
Rituximab
Therapeutics

Keywords

  • Auto-immune
  • Hepatitis
  • Rituximab

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Rituximab for refractory autoimmune hepatitis : A case report. / Al-Busafi, Said A.; Michel, René P.; Deschenes, Marc.

In: Arab Journal of Gastroenterology, Vol. 14, No. 3, 09.2013, p. 135-138.

Research output: Contribution to journalArticle

Al-Busafi, Said A. ; Michel, René P. ; Deschenes, Marc. / Rituximab for refractory autoimmune hepatitis : A case report. In: Arab Journal of Gastroenterology. 2013 ; Vol. 14, No. 3. pp. 135-138.
@article{632ca8370d144f0e8f124a021e032ad9,
title = "Rituximab for refractory autoimmune hepatitis: A case report",
abstract = "Auto-immune hepatitis (AIH) is a chronic progressive hepatitis of unknown aetiology whose clinical presentation ranges from asymptomatic to fulminant hepatic failure. Corticosteroids and azathioprine, which are considered standard therapy for AIH, may, however, be associated with treatment failures and toxicities. Among the alternative medications under investigation, rituximab, used to treat successfully various auto-immune disorders, has fewer side effects. We report herein the case of a 68-year-old woman who developed AIH with worsening clinical, laboratory and histological features despite high-dose prednisone. On rituximab, the patient showed rapid and dramatic clinical improvement, suggesting a therapeutic role for this medication in severe AIH. Indeed, prospective controlled studies are needed to assess and validate this role.",
keywords = "Auto-immune, Hepatitis, Rituximab",
author = "Al-Busafi, {Said A.} and Michel, {Ren{\'e} P.} and Marc Deschenes",
year = "2013",
month = "9",
doi = "10.1016/j.ajg.2013.08.009",
language = "English",
volume = "14",
pages = "135--138",
journal = "Arab Journal of Gastroenterology",
issn = "1687-1979",
publisher = "Elsevier BV",
number = "3",

}

TY - JOUR

T1 - Rituximab for refractory autoimmune hepatitis

T2 - A case report

AU - Al-Busafi, Said A.

AU - Michel, René P.

AU - Deschenes, Marc

PY - 2013/9

Y1 - 2013/9

N2 - Auto-immune hepatitis (AIH) is a chronic progressive hepatitis of unknown aetiology whose clinical presentation ranges from asymptomatic to fulminant hepatic failure. Corticosteroids and azathioprine, which are considered standard therapy for AIH, may, however, be associated with treatment failures and toxicities. Among the alternative medications under investigation, rituximab, used to treat successfully various auto-immune disorders, has fewer side effects. We report herein the case of a 68-year-old woman who developed AIH with worsening clinical, laboratory and histological features despite high-dose prednisone. On rituximab, the patient showed rapid and dramatic clinical improvement, suggesting a therapeutic role for this medication in severe AIH. Indeed, prospective controlled studies are needed to assess and validate this role.

AB - Auto-immune hepatitis (AIH) is a chronic progressive hepatitis of unknown aetiology whose clinical presentation ranges from asymptomatic to fulminant hepatic failure. Corticosteroids and azathioprine, which are considered standard therapy for AIH, may, however, be associated with treatment failures and toxicities. Among the alternative medications under investigation, rituximab, used to treat successfully various auto-immune disorders, has fewer side effects. We report herein the case of a 68-year-old woman who developed AIH with worsening clinical, laboratory and histological features despite high-dose prednisone. On rituximab, the patient showed rapid and dramatic clinical improvement, suggesting a therapeutic role for this medication in severe AIH. Indeed, prospective controlled studies are needed to assess and validate this role.

KW - Auto-immune

KW - Hepatitis

KW - Rituximab

UR - http://www.scopus.com/inward/record.url?scp=84886293039&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84886293039&partnerID=8YFLogxK

U2 - 10.1016/j.ajg.2013.08.009

DO - 10.1016/j.ajg.2013.08.009

M3 - Article

C2 - 24206745

AN - SCOPUS:84886293039

VL - 14

SP - 135

EP - 138

JO - Arab Journal of Gastroenterology

JF - Arab Journal of Gastroenterology

SN - 1687-1979

IS - 3

ER -