Risks of red blood cell alloimmunization in transfusion-dependent β-thalassemia in Oman: A 25-year experience of a university tertiary care reference center and a literature review

Arwa Z. Al-Riyami, Ayman Al-Muqbali, Saif Al-Sudiri, Sathiya Murthi Panchatcharam, Mathew Zacharia, Sabah Al-Mahrooqi, Saif Al-Hosni, Ali Al-Marhoobi, Shahina Daar

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

BACKGROUND: β-Thalassemia is a common hemoglobinopathy in the Arabian Peninsula. Red blood cell (RBC) transfusion is a cornerstone for its management, but can create significant challenges including RBC alloimmunization. Herein, we examine alloimmunization risk factors in Omani patients with transfusion-dependent β-thalassemia. Existing literature is summarized. STUDY DESIGN AND METHODS: A retrospective review of all patients attending our center over 25 years was performed. Clinical and transfusion records were examined. Chi-square test was used to assess the association between the categorical variables. Nonparametric Mann-Whitney test was used to assess the association between transfusion and risk of alloimmunization. RESULTS: A total of 268 patients were identified (168 adults and 100 pediatrics), of whom 226 are alive (84.3%). Males accounted for 53.4%. The cohort had a median age of 22 years (range, 2-43 years). The most common blood group was O+ (39%). The prevalence of alloimmunization was 9.3% with anti-E (24%) and anti-K (24%) being the commonest antibodies identified. There was a significant association between age and alloimmunization, with 68% of alloimmunized patients in the age group of 19 to 30 years (p < 0.01). Among adults, there was a significant association between alloimmunization and number of units transfused (p = 0.001). There was no association between alloimmunization and sex or history of splenectomy. CONCLUSION: Our study shows an association between alloimmunization and the age of the patients and number of units transfused. Transfusion support of this group of patients necessitates the availability of needed expertise and blood bank facilities.

Original languageEnglish
JournalTransfusion
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Oman
Thalassemia
Tertiary Care Centers
Erythrocytes
Hemoglobinopathies
Erythrocyte Transfusion
Blood Banks
Self-Help Groups
Splenectomy
Chi-Square Distribution
Blood Group Antigens
Age Groups
Pediatrics
Antibodies

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Hematology

Cite this

Risks of red blood cell alloimmunization in transfusion-dependent β-thalassemia in Oman : A 25-year experience of a university tertiary care reference center and a literature review. / Al-Riyami, Arwa Z.; Al-Muqbali, Ayman; Al-Sudiri, Saif; Murthi Panchatcharam, Sathiya; Zacharia, Mathew; Al-Mahrooqi, Sabah; Al-Hosni, Saif; Al-Marhoobi, Ali; Daar, Shahina.

In: Transfusion, 01.01.2018.

Research output: Contribution to journalArticle

Al-Riyami, Arwa Z. ; Al-Muqbali, Ayman ; Al-Sudiri, Saif ; Murthi Panchatcharam, Sathiya ; Zacharia, Mathew ; Al-Mahrooqi, Sabah ; Al-Hosni, Saif ; Al-Marhoobi, Ali ; Daar, Shahina. / Risks of red blood cell alloimmunization in transfusion-dependent β-thalassemia in Oman : A 25-year experience of a university tertiary care reference center and a literature review. In: Transfusion. 2018.
@article{842e6f7379684ab89070b28460047db9,
title = "Risks of red blood cell alloimmunization in transfusion-dependent β-thalassemia in Oman: A 25-year experience of a university tertiary care reference center and a literature review",
abstract = "BACKGROUND: β-Thalassemia is a common hemoglobinopathy in the Arabian Peninsula. Red blood cell (RBC) transfusion is a cornerstone for its management, but can create significant challenges including RBC alloimmunization. Herein, we examine alloimmunization risk factors in Omani patients with transfusion-dependent β-thalassemia. Existing literature is summarized. STUDY DESIGN AND METHODS: A retrospective review of all patients attending our center over 25 years was performed. Clinical and transfusion records were examined. Chi-square test was used to assess the association between the categorical variables. Nonparametric Mann-Whitney test was used to assess the association between transfusion and risk of alloimmunization. RESULTS: A total of 268 patients were identified (168 adults and 100 pediatrics), of whom 226 are alive (84.3{\%}). Males accounted for 53.4{\%}. The cohort had a median age of 22 years (range, 2-43 years). The most common blood group was O+ (39{\%}). The prevalence of alloimmunization was 9.3{\%} with anti-E (24{\%}) and anti-K (24{\%}) being the commonest antibodies identified. There was a significant association between age and alloimmunization, with 68{\%} of alloimmunized patients in the age group of 19 to 30 years (p < 0.01). Among adults, there was a significant association between alloimmunization and number of units transfused (p = 0.001). There was no association between alloimmunization and sex or history of splenectomy. CONCLUSION: Our study shows an association between alloimmunization and the age of the patients and number of units transfused. Transfusion support of this group of patients necessitates the availability of needed expertise and blood bank facilities.",
author = "Al-Riyami, {Arwa Z.} and Ayman Al-Muqbali and Saif Al-Sudiri and {Murthi Panchatcharam}, Sathiya and Mathew Zacharia and Sabah Al-Mahrooqi and Saif Al-Hosni and Ali Al-Marhoobi and Shahina Daar",
year = "2018",
month = "1",
day = "1",
doi = "10.1111/trf.14508",
language = "English",
journal = "Transfusion",
issn = "0041-1132",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Risks of red blood cell alloimmunization in transfusion-dependent β-thalassemia in Oman

T2 - A 25-year experience of a university tertiary care reference center and a literature review

AU - Al-Riyami, Arwa Z.

AU - Al-Muqbali, Ayman

AU - Al-Sudiri, Saif

AU - Murthi Panchatcharam, Sathiya

AU - Zacharia, Mathew

AU - Al-Mahrooqi, Sabah

AU - Al-Hosni, Saif

AU - Al-Marhoobi, Ali

AU - Daar, Shahina

PY - 2018/1/1

Y1 - 2018/1/1

N2 - BACKGROUND: β-Thalassemia is a common hemoglobinopathy in the Arabian Peninsula. Red blood cell (RBC) transfusion is a cornerstone for its management, but can create significant challenges including RBC alloimmunization. Herein, we examine alloimmunization risk factors in Omani patients with transfusion-dependent β-thalassemia. Existing literature is summarized. STUDY DESIGN AND METHODS: A retrospective review of all patients attending our center over 25 years was performed. Clinical and transfusion records were examined. Chi-square test was used to assess the association between the categorical variables. Nonparametric Mann-Whitney test was used to assess the association between transfusion and risk of alloimmunization. RESULTS: A total of 268 patients were identified (168 adults and 100 pediatrics), of whom 226 are alive (84.3%). Males accounted for 53.4%. The cohort had a median age of 22 years (range, 2-43 years). The most common blood group was O+ (39%). The prevalence of alloimmunization was 9.3% with anti-E (24%) and anti-K (24%) being the commonest antibodies identified. There was a significant association between age and alloimmunization, with 68% of alloimmunized patients in the age group of 19 to 30 years (p < 0.01). Among adults, there was a significant association between alloimmunization and number of units transfused (p = 0.001). There was no association between alloimmunization and sex or history of splenectomy. CONCLUSION: Our study shows an association between alloimmunization and the age of the patients and number of units transfused. Transfusion support of this group of patients necessitates the availability of needed expertise and blood bank facilities.

AB - BACKGROUND: β-Thalassemia is a common hemoglobinopathy in the Arabian Peninsula. Red blood cell (RBC) transfusion is a cornerstone for its management, but can create significant challenges including RBC alloimmunization. Herein, we examine alloimmunization risk factors in Omani patients with transfusion-dependent β-thalassemia. Existing literature is summarized. STUDY DESIGN AND METHODS: A retrospective review of all patients attending our center over 25 years was performed. Clinical and transfusion records were examined. Chi-square test was used to assess the association between the categorical variables. Nonparametric Mann-Whitney test was used to assess the association between transfusion and risk of alloimmunization. RESULTS: A total of 268 patients were identified (168 adults and 100 pediatrics), of whom 226 are alive (84.3%). Males accounted for 53.4%. The cohort had a median age of 22 years (range, 2-43 years). The most common blood group was O+ (39%). The prevalence of alloimmunization was 9.3% with anti-E (24%) and anti-K (24%) being the commonest antibodies identified. There was a significant association between age and alloimmunization, with 68% of alloimmunized patients in the age group of 19 to 30 years (p < 0.01). Among adults, there was a significant association between alloimmunization and number of units transfused (p = 0.001). There was no association between alloimmunization and sex or history of splenectomy. CONCLUSION: Our study shows an association between alloimmunization and the age of the patients and number of units transfused. Transfusion support of this group of patients necessitates the availability of needed expertise and blood bank facilities.

UR - http://www.scopus.com/inward/record.url?scp=85041590223&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85041590223&partnerID=8YFLogxK

U2 - 10.1111/trf.14508

DO - 10.1111/trf.14508

M3 - Article

AN - SCOPUS:85041590223

JO - Transfusion

JF - Transfusion

SN - 0041-1132

ER -