Retinopathy of prematurity

Revisiting incidence and risk factors from Oman compared to other countries

Zenaida Reyes, Sharef Al-Mulaabed, Flordeliz Bataclan, Cheryl Montemayor, Anuradha Ganesh, Sanaa Al-Zuhaibi, Huda Al-Waili, Fatma Al-Wahibi

Research output: Contribution to journalArticle

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Abstract

Purpose: The purpose of this study is to determine the incidence of retinopathy of prematurity (ROP) and the maternal/neonatal risk factors at a tertiary care hospital in Oman, compared to other countries. Patients and Methods: A retrospective analysis of premature neonates born with gestational age (GA) 24-32 weeks at Sultan Qaboos University Hospital, Oman, from January 2007 to December 2010. Maternal and neonatal in-hospital course was retrieved. The incidence of ROP was reported. Risk factors analyses were performed using univariate and multivariate statistics. Results: A total of 171 neonates (57% males, 43% females) were included for analysis. The incidence of ROP (any stage) was 69/171 (40.4%). Infants with ROP had significantly lower GA (27.7±2 weeks) compared to non-ROP group (30.2±1.7 weeks), P < 0.001),P < 0.001) and significantly lower birth weight (BW) (948 ± 242 g in ROP group vs. 1348 ± 283 g in non-ROP group;P < 0.001). Other significant risk factors associated with ROP were: small for GA, respiratory distress syndrome, requirement for ventilation, duration of ventilation or oxygen therapy, bronchopulmonary dysplasia, hyperglycemia, late onset sepsis (clinical or proven), necrotizing enterocolitis, patent ductus arteriosus, seizures, and number of blood transfusions. There was no significant difference in maternal characteristics between the ROP and non-ROP groups except that mothers of infants with ROP were found to be significantly younger. Logistic regression analysis revealed early GA, low BW, duration of Oxygen therapy, and late-onset clinical or proven sepsis as independent risk factors. Conclusion: ROP is still commonly encountered in neonatal practice in Oman and other countries. Early GA, low BW, and prolonged oxygen therapy continue to be the main risk factors associated with the occurrence of ROP in our setting. In addition, an important preventable risk factor identified in our cohort includes clinical or proven late-onset sepsis.

Original languageEnglish
Pages (from-to)26-32
Number of pages7
JournalOman Journal of Ophthalmology
Volume10
Issue number1
DOIs
Publication statusPublished - Jan 1 2017

Fingerprint

Oman
Retinopathy of Prematurity
Incidence
Gestational Age
Mothers
Sepsis
Low Birth Weight Infant
Oxygen
Ventilation
Newborn Infant
Bronchopulmonary Dysplasia
Necrotizing Enterocolitis
Patent Ductus Arteriosus
Tertiary Healthcare
Tertiary Care Centers
Birth Weight
Blood Transfusion
Hyperglycemia
Statistical Factor Analysis
Seizures

Keywords

  • Incidence
  • neonates
  • Oman
  • premature
  • retinopathy of prematurity
  • risk factors

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Retinopathy of prematurity : Revisiting incidence and risk factors from Oman compared to other countries. / Reyes, Zenaida; Al-Mulaabed, Sharef; Bataclan, Flordeliz; Montemayor, Cheryl; Ganesh, Anuradha; Al-Zuhaibi, Sanaa; Al-Waili, Huda; Al-Wahibi, Fatma.

In: Oman Journal of Ophthalmology, Vol. 10, No. 1, 01.01.2017, p. 26-32.

Research output: Contribution to journalArticle

Reyes, Zenaida ; Al-Mulaabed, Sharef ; Bataclan, Flordeliz ; Montemayor, Cheryl ; Ganesh, Anuradha ; Al-Zuhaibi, Sanaa ; Al-Waili, Huda ; Al-Wahibi, Fatma. / Retinopathy of prematurity : Revisiting incidence and risk factors from Oman compared to other countries. In: Oman Journal of Ophthalmology. 2017 ; Vol. 10, No. 1. pp. 26-32.
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