Results from the Survey of Antibiotic Resistance (SOAR) 2011-13 in the Gulf States

A. Jamsheer, A. M. Rafay, Z. Daoud, I. Morrissey, D. Torumkuney

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objectives: To provide surveillance data on the susceptibility of community-acquired respiratory tract isolates from four Gulf and Near East countries from 2011 to 2013. Methods: MICs were determined using Etestsw for all antibiotics evaluated except erythromycin, where testing was by disc diffusion. Susceptibility was assessed using CLSI, EUCAST and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. Results: Seven hundred and twenty-six respiratory isolates comprising 265 isolates of Streptococcus pneumoniae, 125 isolates of Streptococcus pyogenes and 336 isolates of Haemophilus influenzae were collected from Bahrain, Lebanon, Oman and the United Arab Emirates (UAE). Among S. pneumoniae, susceptibility to penicillin was low in the UAE and Bahrain. Macrolide susceptibility was 45%-60% in the UAE and Oman but higher in Lebanon (73.7%) and Bahrain (84%-85%). Penicillin susceptibility using CLSI intravenous breakpoints was >85% in all countries. Antibiotic susceptibility of S. pneumoniae was lower in UAE and Oman. Among S. pyogenes isolates, resistance to erythromycin was highest in Oman (31.6%) but <20% in the other countries. In H. influenzae, susceptibility to most antibiotics was high, except for ampicillin in Lebanon (70.2%) and amoxicillin in Oman (95.4%). Lebanon also had a high percentage (14.9%) of b-lactamase-positive isolates with non-susceptibility to ampicillin. Amoxicillin/clavulanic acid susceptibility was >95% in all countries. Use of EUCAST versus CLSI breakpoints demonstrated profound differences for cefaclor and cefuroxime in S. pneumoniae and H. influenzae, with EUCAST showing lower susceptibility. Conclusions: There was considerable variability in susceptibility among countries in the same region. Thus, continued surveillance is necessary to track future changes in antibiotic resistance.

Original languageEnglish
Pages (from-to)i45-i61
JournalJournal of Antimicrobial Chemotherapy
Volume71
DOIs
Publication statusPublished - May 1 2016

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United Arab Emirates
Oman
Bahrain
Microbial Drug Resistance
Streptococcus pneumoniae
Lebanon
Streptococcus pyogenes
Haemophilus influenzae
Erythromycin
Penicillins
Cefaclor
Anti-Bacterial Agents
Cefuroxime
Middle East
Macrolides
Respiratory System
Pharmacokinetics
Surveys and Questionnaires

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Results from the Survey of Antibiotic Resistance (SOAR) 2011-13 in the Gulf States. / Jamsheer, A.; Rafay, A. M.; Daoud, Z.; Morrissey, I.; Torumkuney, D.

In: Journal of Antimicrobial Chemotherapy, Vol. 71, 01.05.2016, p. i45-i61.

Research output: Contribution to journalArticle

Jamsheer, A. ; Rafay, A. M. ; Daoud, Z. ; Morrissey, I. ; Torumkuney, D. / Results from the Survey of Antibiotic Resistance (SOAR) 2011-13 in the Gulf States. In: Journal of Antimicrobial Chemotherapy. 2016 ; Vol. 71. pp. i45-i61.
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abstract = "Objectives: To provide surveillance data on the susceptibility of community-acquired respiratory tract isolates from four Gulf and Near East countries from 2011 to 2013. Methods: MICs were determined using Etestsw for all antibiotics evaluated except erythromycin, where testing was by disc diffusion. Susceptibility was assessed using CLSI, EUCAST and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. Results: Seven hundred and twenty-six respiratory isolates comprising 265 isolates of Streptococcus pneumoniae, 125 isolates of Streptococcus pyogenes and 336 isolates of Haemophilus influenzae were collected from Bahrain, Lebanon, Oman and the United Arab Emirates (UAE). Among S. pneumoniae, susceptibility to penicillin was low in the UAE and Bahrain. Macrolide susceptibility was 45{\%}-60{\%} in the UAE and Oman but higher in Lebanon (73.7{\%}) and Bahrain (84{\%}-85{\%}). Penicillin susceptibility using CLSI intravenous breakpoints was >85{\%} in all countries. Antibiotic susceptibility of S. pneumoniae was lower in UAE and Oman. Among S. pyogenes isolates, resistance to erythromycin was highest in Oman (31.6{\%}) but <20{\%} in the other countries. In H. influenzae, susceptibility to most antibiotics was high, except for ampicillin in Lebanon (70.2{\%}) and amoxicillin in Oman (95.4{\%}). Lebanon also had a high percentage (14.9{\%}) of b-lactamase-positive isolates with non-susceptibility to ampicillin. Amoxicillin/clavulanic acid susceptibility was >95{\%} in all countries. Use of EUCAST versus CLSI breakpoints demonstrated profound differences for cefaclor and cefuroxime in S. pneumoniae and H. influenzae, with EUCAST showing lower susceptibility. Conclusions: There was considerable variability in susceptibility among countries in the same region. Thus, continued surveillance is necessary to track future changes in antibiotic resistance.",
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