Responses of alveolar macrophages to post-Gulf-War airborne dust from Kuwait

Charles I. Ezeamuzie*, Mirza U. Beg, Dhari Al-Ajmi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

The effects of the extracts and particles of the post oil fire airborne dust collected from air conditioner filters in the Ahmadi area of Kuwait in 1991-1995 on the in vitro spontaneous and PMA-stimulated generation of superoxide (O2) ions from guinea pig alveolar macrophages (AM) and lipopolysaccharide (LPS)-stimulated tumor necrosis factor (TNFα) release from mouse (AM) were studied. Treatment of adherent AM with aqueous extract of the 1991 dust (0.6-10 mg/mL) resulted in a dose-dependent inhibition of basal, as well as PMA-induced O2 release. Fifty inhibition of O2-release was achieved by extracts of 1-2.4 mg/mL of the dust and at 10 mg/mL, the maximal inhibition was 79-88%.

Original languageEnglish
Pages (from-to)213-220
Number of pages8
JournalEnvironment international
Volume24
Issue number1-2
DOIs
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Environmental Science(all)

Fingerprint

Dive into the research topics of 'Responses of alveolar macrophages to post-Gulf-War airborne dust from Kuwait'. Together they form a unique fingerprint.

Cite this