TY - JOUR
T1 - Responses of alveolar macrophages to post-Gulf-War airborne dust from Kuwait
AU - Ezeamuzie, Charles I.
AU - Beg, Mirza U.
AU - Al-Ajmi, Dhari
N1 - Funding Information:
Acknowledgment--This work was supported by the Kuwait Institute for Scientific Research and Kuwait University. We are grateful to Mrs. Mary A1-Hage for her excellent technical assistance.
PY - 1998
Y1 - 1998
N2 - The effects of the extracts and particles of the post oil fire airborne dust collected from air conditioner filters in the Ahmadi area of Kuwait in 1991-1995 on the in vitro spontaneous and PMA-stimulated generation of superoxide (O2) ions from guinea pig alveolar macrophages (AM) and lipopolysaccharide (LPS)-stimulated tumor necrosis factor (TNFα) release from mouse (AM) were studied. Treatment of adherent AM with aqueous extract of the 1991 dust (0.6-10 mg/mL) resulted in a dose-dependent inhibition of basal, as well as PMA-induced O2 release. Fifty inhibition of O2-release was achieved by extracts of 1-2.4 mg/mL of the dust and at 10 mg/mL, the maximal inhibition was 79-88%.
AB - The effects of the extracts and particles of the post oil fire airborne dust collected from air conditioner filters in the Ahmadi area of Kuwait in 1991-1995 on the in vitro spontaneous and PMA-stimulated generation of superoxide (O2) ions from guinea pig alveolar macrophages (AM) and lipopolysaccharide (LPS)-stimulated tumor necrosis factor (TNFα) release from mouse (AM) were studied. Treatment of adherent AM with aqueous extract of the 1991 dust (0.6-10 mg/mL) resulted in a dose-dependent inhibition of basal, as well as PMA-induced O2 release. Fifty inhibition of O2-release was achieved by extracts of 1-2.4 mg/mL of the dust and at 10 mg/mL, the maximal inhibition was 79-88%.
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U2 - 10.1016/S0160-4120(97)00138-4
DO - 10.1016/S0160-4120(97)00138-4
M3 - Article
AN - SCOPUS:0031933916
SN - 0160-4120
VL - 24
SP - 213
EP - 220
JO - Environment international
JF - Environment international
IS - 1-2
ER -