TY - JOUR
T1 - Resection marginal width and positive margin of transurethral resection of bladder tumor are associated with bladder cancer early recurrence
AU - Wei, Xiao Song
AU - Li, Fan
AU - Siddiqui, Khurram Mutahir
AU - Zhuang, Qian Yuan
AU - Hu, Zhi Quan
AU - Song, Xiao Dong
AU - Chen, Zhong
AU - Yang, Wei Min
AU - Wang, Shao Gang
N1 - Publisher Copyright:
© 2016, E-Century Publishing Corporation. All rights reserved.
PY - 2016/12/20
Y1 - 2016/12/20
N2 - Objective: To investigate the relationship between the marginal width of transurethral resection of bladder tumor (TURBT) and bladder cancer recurrence to define the ideal resection marginal width. Methods: Medical records of 143 patients with non-muscle invasive bladder cancer were retrospectively reviewed. The patients were divided into three groups according to the width of resection margin. All patients were followed for a minimum of 24 months to investigate the timing of tumor recurrence and recurrence in situ. Log-rank test, Cox regression, and Kaplan-Meier estimator were performed to compare the three groups, respectively. Results: Tumor size, primary/recurrent tumor, pathological grade, resection marginal width, and margin status affected the tumor recurrence. The same factors also affected the tumor recurrence in situ. The recurrence and the recurrence in situ rate of 10 mm marginal width group were significantly higher than 15 mm and 20 mm marginal width groups (P = 0.005); similarly, the recurrence and the recurrence in situ rate in patients with positive margin were higher than those with negative margin (P < 0.001). The postoperative complication rate in 20 mm marginal width group was significantly higher compared with the 10 mm and 15 mm groups (P = 0.041). Conclusions: The positive margin of TURBT is associated with increased risk of both tumor recurrence and recurrence in situ. We recommend a marginal width of 15 mm as the preferable standard, based on reduced the rates of recurrence, without any significant increase in the postoperative complications found in this group.
AB - Objective: To investigate the relationship between the marginal width of transurethral resection of bladder tumor (TURBT) and bladder cancer recurrence to define the ideal resection marginal width. Methods: Medical records of 143 patients with non-muscle invasive bladder cancer were retrospectively reviewed. The patients were divided into three groups according to the width of resection margin. All patients were followed for a minimum of 24 months to investigate the timing of tumor recurrence and recurrence in situ. Log-rank test, Cox regression, and Kaplan-Meier estimator were performed to compare the three groups, respectively. Results: Tumor size, primary/recurrent tumor, pathological grade, resection marginal width, and margin status affected the tumor recurrence. The same factors also affected the tumor recurrence in situ. The recurrence and the recurrence in situ rate of 10 mm marginal width group were significantly higher than 15 mm and 20 mm marginal width groups (P = 0.005); similarly, the recurrence and the recurrence in situ rate in patients with positive margin were higher than those with negative margin (P < 0.001). The postoperative complication rate in 20 mm marginal width group was significantly higher compared with the 10 mm and 15 mm groups (P = 0.041). Conclusions: The positive margin of TURBT is associated with increased risk of both tumor recurrence and recurrence in situ. We recommend a marginal width of 15 mm as the preferable standard, based on reduced the rates of recurrence, without any significant increase in the postoperative complications found in this group.
KW - Non-muscle invasive bladder cancer
KW - Transurethral resection of bladder tumor
KW - Tumor margin
KW - Tumor recurrence
KW - Tumor recurrence in situ
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M3 - Article
AN - SCOPUS:85002323742
SN - 1940-5901
VL - 9
SP - 21625
EP - 21634
JO - International Journal of Clinical and Experimental Medicine
JF - International Journal of Clinical and Experimental Medicine
IS - 11
M1 - IJCEM0035500
ER -