@article{4167b6795e7b4121a4c7b23286821c33,
title = "Renal cystic disease in tuberous sclerosis complex",
abstract = "Tuberous sclerosis complex (TSC) is associated with TSC1 or TSC2 gene mutations resulting in hyperactivation of the mTORC1 pathway. This mTORC1 activation is associated with abnormal tissue development and proliferation such that in the kidney there are both solid tumors and cystic lesions. This review summarizes recent advances in tuberous sclerosis complex nephrology and focuses on the genetics and cell biology of tuberous sclerosis complex renal disease, highlighting a role of extracellular vesicles and the innate immune system in disease pathogenesis.",
keywords = "cell nonautonomous trait, extracellular vesicles, renal cysts, Tuberous sclerosis complex",
author = "Prashant Kumar and Fahad Zadjali and Ying Yao and Bissler, {John J.}",
note = "Funding Information: I (the corresponding author) am grateful for this opportunity to publish a paper in remembrance of Peter Stambrook, PhD. Having the privilege of his friendship was one of the best things I carry with me from my time in Cincinnati. The figure was created with BioRender.com. The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the DoD grant W81XWH-14-1-0343 (JJB), Federal Express Chair of Excellence (JJB), and Children?s Foundation Research Institute (JJB). Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the DoD grant W81XWH-14-1-0343 (JJB), Federal Express Chair of Excellence (JJB), and Children{\textquoteright}s Foundation Research Institute (JJB). Publisher Copyright: {\textcopyright} 2021 by the Society for Experimental Biology and Medicine.",
year = "2021",
month = oct,
doi = "10.1177/15353702211038378",
language = "English",
volume = "246",
pages = "2111--2117",
journal = "Experimental Biology and Medicine",
issn = "1535-3702",
publisher = "SAGE Publications Ltd",
number = "19",
}