TY - JOUR
T1 - REM Sleep-Dependent Bidirectional Regulation of Hippocampal-Based Emotional Memory and LTP
AU - Ravassard, Pascal
AU - Hamieh, Al Mahdy
AU - Joseph, Mickaël Antoine
AU - Fraize, Nicolas
AU - Libourel, Paul Antoine
AU - Lebarillier, Léa
AU - Arthaud, Sébastien
AU - Meissirel, Claire
AU - Touret, Monique
AU - Malleret, Gaël
AU - Salin, Paul Antoine
N1 - Publisher Copyright:
© 2015 The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Prolonged rapid-eye-movement (REM) sleep deprivation has long been used to study the role of REM sleep in learning and memory processes. However, this method potentially induces stress and fatigue that may directly affect cognitive functions. Here, by using a short-term and nonstressful REM sleep deprivation (RSD) method we assessed in rats the bidirectional influence of reduced and increased REM sleep amount on hippocampal-dependent emotional memory and plasticity. Our results indicate that 4 h RSD impaired consolidation of contextual fear conditioning (CFC) and induction of long-term potentiation (LTP), while decreasing density of Egr1/Zif268-expressing neurons in the CA1 region of the dorsal hippocampus. LTP and Egr1 expression were not affected in ventral CA1. Conversely, an increase in REM sleep restores and further facilitates CFC consolidation and LTP induction, and also increases Egr1 expression in dorsal CA1. Moreover, CFC consolidation, Egr1 neuron density, and LTP amplitude in dorsal CA1 show a positive correlation with REM sleep amount. Altogether, these results indicate that mild changes in REM sleep amount bidirectionally affect memory and synaptic plasticity mechanisms occurring in the CA1 area of the dorsal hippocampus.
AB - Prolonged rapid-eye-movement (REM) sleep deprivation has long been used to study the role of REM sleep in learning and memory processes. However, this method potentially induces stress and fatigue that may directly affect cognitive functions. Here, by using a short-term and nonstressful REM sleep deprivation (RSD) method we assessed in rats the bidirectional influence of reduced and increased REM sleep amount on hippocampal-dependent emotional memory and plasticity. Our results indicate that 4 h RSD impaired consolidation of contextual fear conditioning (CFC) and induction of long-term potentiation (LTP), while decreasing density of Egr1/Zif268-expressing neurons in the CA1 region of the dorsal hippocampus. LTP and Egr1 expression were not affected in ventral CA1. Conversely, an increase in REM sleep restores and further facilitates CFC consolidation and LTP induction, and also increases Egr1 expression in dorsal CA1. Moreover, CFC consolidation, Egr1 neuron density, and LTP amplitude in dorsal CA1 show a positive correlation with REM sleep amount. Altogether, these results indicate that mild changes in REM sleep amount bidirectionally affect memory and synaptic plasticity mechanisms occurring in the CA1 area of the dorsal hippocampus.
KW - Egr1/Zif268
KW - contextual fear conditioning
KW - dorsal CA1 area
KW - short-term REM sleep deprivation
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U2 - 10.1093/cercor/bhu310
DO - 10.1093/cercor/bhu310
M3 - Article
C2 - 25585510
AN - SCOPUS:84963831037
SN - 1047-3211
VL - 26
SP - 1488
EP - 1500
JO - Cerebral Cortex
JF - Cerebral Cortex
IS - 4
ER -