REM Sleep-Dependent Bidirectional Regulation of Hippocampal-Based Emotional Memory and LTP

Pascal Ravassard, Al Mahdy Hamieh, Mickaël Antoine Joseph, Nicolas Fraize, Paul Antoine Libourel, Léa Lebarillier, Sébastien Arthaud, Claire Meissirel, Monique Touret, Gaël Malleret, Paul Antoine Salin

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Prolonged rapid-eye-movement (REM) sleep deprivation has long been used to study the role of REM sleep in learning and memory processes. However, this method potentially induces stress and fatigue that may directly affect cognitive functions. Here, by using a short-term and nonstressful REM sleep deprivation (RSD) method we assessed in rats the bidirectional influence of reduced and increased REM sleep amount on hippocampal-dependent emotional memory and plasticity. Our results indicate that 4 h RSD impaired consolidation of contextual fear conditioning (CFC) and induction of long-term potentiation (LTP), while decreasing density of Egr1/Zif268-expressing neurons in the CA1 region of the dorsal hippocampus. LTP and Egr1 expression were not affected in ventral CA1. Conversely, an increase in REM sleep restores and further facilitates CFC consolidation and LTP induction, and also increases Egr1 expression in dorsal CA1. Moreover, CFC consolidation, Egr1 neuron density, and LTP amplitude in dorsal CA1 show a positive correlation with REM sleep amount. Altogether, these results indicate that mild changes in REM sleep amount bidirectionally affect memory and synaptic plasticity mechanisms occurring in the CA1 area of the dorsal hippocampus.

Original languageEnglish
Pages (from-to)1488-1500
Number of pages13
JournalCerebral Cortex
Volume26
Issue number4
DOIs
Publication statusPublished - Apr 1 2016

Fingerprint

Long-Term Potentiation
REM Sleep
Sleep
Sleep Deprivation
Fear
Hippocampus
Neurons
Neuronal Plasticity
Cognition
Fatigue
Learning
Conditioning (Psychology)

Keywords

  • contextual fear conditioning
  • dorsal CA1 area
  • Egr1/Zif268
  • short-term REM sleep deprivation

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Ravassard, P., Hamieh, A. M., Joseph, M. A., Fraize, N., Libourel, P. A., Lebarillier, L., ... Salin, P. A. (2016). REM Sleep-Dependent Bidirectional Regulation of Hippocampal-Based Emotional Memory and LTP. Cerebral Cortex, 26(4), 1488-1500. https://doi.org/10.1093/cercor/bhu310

REM Sleep-Dependent Bidirectional Regulation of Hippocampal-Based Emotional Memory and LTP. / Ravassard, Pascal; Hamieh, Al Mahdy; Joseph, Mickaël Antoine; Fraize, Nicolas; Libourel, Paul Antoine; Lebarillier, Léa; Arthaud, Sébastien; Meissirel, Claire; Touret, Monique; Malleret, Gaël; Salin, Paul Antoine.

In: Cerebral Cortex, Vol. 26, No. 4, 01.04.2016, p. 1488-1500.

Research output: Contribution to journalArticle

Ravassard, P, Hamieh, AM, Joseph, MA, Fraize, N, Libourel, PA, Lebarillier, L, Arthaud, S, Meissirel, C, Touret, M, Malleret, G & Salin, PA 2016, 'REM Sleep-Dependent Bidirectional Regulation of Hippocampal-Based Emotional Memory and LTP', Cerebral Cortex, vol. 26, no. 4, pp. 1488-1500. https://doi.org/10.1093/cercor/bhu310
Ravassard, Pascal ; Hamieh, Al Mahdy ; Joseph, Mickaël Antoine ; Fraize, Nicolas ; Libourel, Paul Antoine ; Lebarillier, Léa ; Arthaud, Sébastien ; Meissirel, Claire ; Touret, Monique ; Malleret, Gaël ; Salin, Paul Antoine. / REM Sleep-Dependent Bidirectional Regulation of Hippocampal-Based Emotional Memory and LTP. In: Cerebral Cortex. 2016 ; Vol. 26, No. 4. pp. 1488-1500.
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