Relationship between conformation and antiviral activity - IV. 5- Ethyl- 2'-deoxyuridin and 5-ethyl-2'-deoxycytidine

Allan L. Stuart; Sashi V.P. Kumar; Sagar V. Gupta; Wajdi M. Zoghaib; Scott Napper; Keith C. Brown; Shajan Mannala; Louis T.J. Delbaere

doi:10.1080/07328319708002568

Relationship between conformation and antiviral activity - IV. 5- Ethyl- 2'-deoxyuridin and 5-ethyl-2'-deoxycytidine

Allan L. Stuart, Sashi V.P. Kumar, Sagar V. Gupta^*, Wajdi M. Zoghaib, Scott Napper, Keith C. Brown, Shajan Mannala, Louis T.J. Delbaere

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

5-Ethyl-2'-deoxyuridine (EtdUrd), though a potent inhibitor of herpes simplex virus (HSV) replication, is rapidly catabolized to produce an inactive pyrimidine base by thymidine and/or uridine phosphorylases. 5- Ethyl-2'-deoxycytidine (EtdCyd) was synthesized to confer metabolic stability and thus improve efficacy against systemic HSV infections. EtdCyd was inactive against HSV in the presence or absence of deaminase inhibitors in VERO cells up to 2 mM. The relationship between molecular conformation and antiherpes activity for EtdUrd and EtdCyd is discussed.

Original language	English
Pages (from-to)	2219-2231
Number of pages	13
Journal	Nucleosides and Nucleotides
Volume	16
Issue number	12
DOIs	https://doi.org/10.1080/07328319708002568
Publication status	Published - 1997
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Genetics

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10.1080/07328319708002568

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title = "Relationship between conformation and antiviral activity - IV. 5- Ethyl- 2'-deoxyuridin and 5-ethyl-2'-deoxycytidine",

abstract = "5-Ethyl-2'-deoxyuridine (EtdUrd), though a potent inhibitor of herpes simplex virus (HSV) replication, is rapidly catabolized to produce an inactive pyrimidine base by thymidine and/or uridine phosphorylases. 5- Ethyl-2'-deoxycytidine (EtdCyd) was synthesized to confer metabolic stability and thus improve efficacy against systemic HSV infections. EtdCyd was inactive against HSV in the presence or absence of deaminase inhibitors in VERO cells up to 2 mM. The relationship between molecular conformation and antiherpes activity for EtdUrd and EtdCyd is discussed.",

author = "Stuart, {Allan L.} and Kumar, {Sashi V.P.} and Gupta, {Sagar V.} and Zoghaib, {Wajdi M.} and Scott Napper and Brown, {Keith C.} and Shajan Mannala and Delbaere, {Louis T.J.}",

year = "1997",

doi = "10.1080/07328319708002568",

language = "English",

volume = "16",

pages = "2219--2231",

journal = "Nucleosides and Nucleotides",

issn = "0732-8311",

publisher = "Marcel Dekker Inc.",

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TY - JOUR

T1 - Relationship between conformation and antiviral activity - IV. 5- Ethyl- 2'-deoxyuridin and 5-ethyl-2'-deoxycytidine

AU - Stuart, Allan L.

AU - Kumar, Sashi V.P.

AU - Gupta, Sagar V.

AU - Zoghaib, Wajdi M.

AU - Napper, Scott

AU - Brown, Keith C.

AU - Mannala, Shajan

AU - Delbaere, Louis T.J.

PY - 1997

Y1 - 1997

N2 - 5-Ethyl-2'-deoxyuridine (EtdUrd), though a potent inhibitor of herpes simplex virus (HSV) replication, is rapidly catabolized to produce an inactive pyrimidine base by thymidine and/or uridine phosphorylases. 5- Ethyl-2'-deoxycytidine (EtdCyd) was synthesized to confer metabolic stability and thus improve efficacy against systemic HSV infections. EtdCyd was inactive against HSV in the presence or absence of deaminase inhibitors in VERO cells up to 2 mM. The relationship between molecular conformation and antiherpes activity for EtdUrd and EtdCyd is discussed.

AB - 5-Ethyl-2'-deoxyuridine (EtdUrd), though a potent inhibitor of herpes simplex virus (HSV) replication, is rapidly catabolized to produce an inactive pyrimidine base by thymidine and/or uridine phosphorylases. 5- Ethyl-2'-deoxycytidine (EtdCyd) was synthesized to confer metabolic stability and thus improve efficacy against systemic HSV infections. EtdCyd was inactive against HSV in the presence or absence of deaminase inhibitors in VERO cells up to 2 mM. The relationship between molecular conformation and antiherpes activity for EtdUrd and EtdCyd is discussed.

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DO - 10.1080/07328319708002568

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JF - Nucleosides and Nucleotides

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Relationship between conformation and antiviral activity - IV. 5- Ethyl- 2'-deoxyuridin and 5-ethyl-2'-deoxycytidine

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