TY - JOUR
T1 - Regional haemodynamic effects of urocortin in the anaesthetized rat
AU - Abdelrahman, Aly M.
AU - Pang, Catherine C.Y.
N1 - Funding Information:
This work is supported by the Heart and Stroke Foundation of B.C. and Yukon.
PY - 2003/4/18
Y1 - 2003/4/18
N2 - Urocortin is an endogenous vasodilator peptide that is related to corticotrophin-releasing factor. We examined the haemodynamic effects of urocortin in thiobutabarbital-anaesthetized rats, via the triple-isotope microspheres technique. Urocortin (3 nmol/kg, i.v. bolus) reduced mean arterial pressure (-25 mm Hg) through a decrease in total peripheral resistance (-43%). This was associated with an increase in cardiac output (+24%) and vasodilatation of the following tissues: heart and stomach (≈300% of baseline); liver, intestine, caecum/colon, skeletal muscle and skin (≈200%); and testes (≈150%). Arterial conductances of the kidneys, spleen and brain were unaffected by urocortin. Neither the vehicle (0.9% NaCl) nor a low dose of urocortin (0.3 nmol/kg) altered any measurements. Therefore, urocortin causes generalized vasodilatation as follows: heart and stomach>liver, intestine, caecum/colon, skeletal muscle and skin>testes.
AB - Urocortin is an endogenous vasodilator peptide that is related to corticotrophin-releasing factor. We examined the haemodynamic effects of urocortin in thiobutabarbital-anaesthetized rats, via the triple-isotope microspheres technique. Urocortin (3 nmol/kg, i.v. bolus) reduced mean arterial pressure (-25 mm Hg) through a decrease in total peripheral resistance (-43%). This was associated with an increase in cardiac output (+24%) and vasodilatation of the following tissues: heart and stomach (≈300% of baseline); liver, intestine, caecum/colon, skeletal muscle and skin (≈200%); and testes (≈150%). Arterial conductances of the kidneys, spleen and brain were unaffected by urocortin. Neither the vehicle (0.9% NaCl) nor a low dose of urocortin (0.3 nmol/kg) altered any measurements. Therefore, urocortin causes generalized vasodilatation as follows: heart and stomach>liver, intestine, caecum/colon, skeletal muscle and skin>testes.
KW - Arterial conductance
KW - Arterial pressure
KW - Blood flow
KW - Cardiac output
KW - Peripheral resistance
KW - Urocortin
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U2 - 10.1016/S0014-2999(03)01568-1
DO - 10.1016/S0014-2999(03)01568-1
M3 - Article
C2 - 12694815
AN - SCOPUS:0037453398
SN - 0014-2999
VL - 466
SP - 317
EP - 321
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 3
ER -