Regional haemodynamic effects of urocortin in the anaesthetized rat

Aly M. Abdelrahman, Catherine C.Y. Pang

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Urocortin is an endogenous vasodilator peptide that is related to corticotrophin-releasing factor. We examined the haemodynamic effects of urocortin in thiobutabarbital-anaesthetized rats, via the triple-isotope microspheres technique. Urocortin (3 nmol/kg, i.v. bolus) reduced mean arterial pressure (-25 mm Hg) through a decrease in total peripheral resistance (-43%). This was associated with an increase in cardiac output (+24%) and vasodilatation of the following tissues: heart and stomach (≈300% of baseline); liver, intestine, caecum/colon, skeletal muscle and skin (≈200%); and testes (≈150%). Arterial conductances of the kidneys, spleen and brain were unaffected by urocortin. Neither the vehicle (0.9% NaCl) nor a low dose of urocortin (0.3 nmol/kg) altered any measurements. Therefore, urocortin causes generalized vasodilatation as follows: heart and stomach>liver, intestine, caecum/colon, skeletal muscle and skin>testes.

Original languageEnglish
Pages (from-to)317-321
Number of pages5
JournalEuropean Journal of Pharmacology
Volume466
Issue number3
DOIs
Publication statusPublished - Apr 18 2003

Fingerprint

Urocortins
Hemodynamics
Vasodilation
Intestines
Testis
Stomach
Colon
Skeletal Muscle
Skin
Liver
Corticotropin-Releasing Hormone
Vasodilator Agents
Microspheres
Isotopes
Cardiac Output
Vascular Resistance
Arterial Pressure
Spleen
Kidney
Peptides

Keywords

  • Arterial conductance
  • Arterial pressure
  • Blood flow
  • Cardiac output
  • Peripheral resistance
  • Urocortin

ASJC Scopus subject areas

  • Pharmacology

Cite this

Regional haemodynamic effects of urocortin in the anaesthetized rat. / Abdelrahman, Aly M.; Pang, Catherine C.Y.

In: European Journal of Pharmacology, Vol. 466, No. 3, 18.04.2003, p. 317-321.

Research output: Contribution to journalArticle

@article{c61744194539433fb75e4660fc8383e7,
title = "Regional haemodynamic effects of urocortin in the anaesthetized rat",
abstract = "Urocortin is an endogenous vasodilator peptide that is related to corticotrophin-releasing factor. We examined the haemodynamic effects of urocortin in thiobutabarbital-anaesthetized rats, via the triple-isotope microspheres technique. Urocortin (3 nmol/kg, i.v. bolus) reduced mean arterial pressure (-25 mm Hg) through a decrease in total peripheral resistance (-43{\%}). This was associated with an increase in cardiac output (+24{\%}) and vasodilatation of the following tissues: heart and stomach (≈300{\%} of baseline); liver, intestine, caecum/colon, skeletal muscle and skin (≈200{\%}); and testes (≈150{\%}). Arterial conductances of the kidneys, spleen and brain were unaffected by urocortin. Neither the vehicle (0.9{\%} NaCl) nor a low dose of urocortin (0.3 nmol/kg) altered any measurements. Therefore, urocortin causes generalized vasodilatation as follows: heart and stomach>liver, intestine, caecum/colon, skeletal muscle and skin>testes.",
keywords = "Arterial conductance, Arterial pressure, Blood flow, Cardiac output, Peripheral resistance, Urocortin",
author = "Abdelrahman, {Aly M.} and Pang, {Catherine C.Y.}",
year = "2003",
month = "4",
day = "18",
doi = "10.1016/S0014-2999(03)01568-1",
language = "English",
volume = "466",
pages = "317--321",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - Regional haemodynamic effects of urocortin in the anaesthetized rat

AU - Abdelrahman, Aly M.

AU - Pang, Catherine C.Y.

PY - 2003/4/18

Y1 - 2003/4/18

N2 - Urocortin is an endogenous vasodilator peptide that is related to corticotrophin-releasing factor. We examined the haemodynamic effects of urocortin in thiobutabarbital-anaesthetized rats, via the triple-isotope microspheres technique. Urocortin (3 nmol/kg, i.v. bolus) reduced mean arterial pressure (-25 mm Hg) through a decrease in total peripheral resistance (-43%). This was associated with an increase in cardiac output (+24%) and vasodilatation of the following tissues: heart and stomach (≈300% of baseline); liver, intestine, caecum/colon, skeletal muscle and skin (≈200%); and testes (≈150%). Arterial conductances of the kidneys, spleen and brain were unaffected by urocortin. Neither the vehicle (0.9% NaCl) nor a low dose of urocortin (0.3 nmol/kg) altered any measurements. Therefore, urocortin causes generalized vasodilatation as follows: heart and stomach>liver, intestine, caecum/colon, skeletal muscle and skin>testes.

AB - Urocortin is an endogenous vasodilator peptide that is related to corticotrophin-releasing factor. We examined the haemodynamic effects of urocortin in thiobutabarbital-anaesthetized rats, via the triple-isotope microspheres technique. Urocortin (3 nmol/kg, i.v. bolus) reduced mean arterial pressure (-25 mm Hg) through a decrease in total peripheral resistance (-43%). This was associated with an increase in cardiac output (+24%) and vasodilatation of the following tissues: heart and stomach (≈300% of baseline); liver, intestine, caecum/colon, skeletal muscle and skin (≈200%); and testes (≈150%). Arterial conductances of the kidneys, spleen and brain were unaffected by urocortin. Neither the vehicle (0.9% NaCl) nor a low dose of urocortin (0.3 nmol/kg) altered any measurements. Therefore, urocortin causes generalized vasodilatation as follows: heart and stomach>liver, intestine, caecum/colon, skeletal muscle and skin>testes.

KW - Arterial conductance

KW - Arterial pressure

KW - Blood flow

KW - Cardiac output

KW - Peripheral resistance

KW - Urocortin

UR - http://www.scopus.com/inward/record.url?scp=0037453398&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037453398&partnerID=8YFLogxK

U2 - 10.1016/S0014-2999(03)01568-1

DO - 10.1016/S0014-2999(03)01568-1

M3 - Article

VL - 466

SP - 317

EP - 321

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 3

ER -