Regional haemodynamic effects of urocortin in the anaesthetized rat

Aly M. Abdelrahman, Catherine C.Y. Pang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Urocortin is an endogenous vasodilator peptide that is related to corticotrophin-releasing factor. We examined the haemodynamic effects of urocortin in thiobutabarbital-anaesthetized rats, via the triple-isotope microspheres technique. Urocortin (3 nmol/kg, i.v. bolus) reduced mean arterial pressure (-25 mm Hg) through a decrease in total peripheral resistance (-43%). This was associated with an increase in cardiac output (+24%) and vasodilatation of the following tissues: heart and stomach (≈300% of baseline); liver, intestine, caecum/colon, skeletal muscle and skin (≈200%); and testes (≈150%). Arterial conductances of the kidneys, spleen and brain were unaffected by urocortin. Neither the vehicle (0.9% NaCl) nor a low dose of urocortin (0.3 nmol/kg) altered any measurements. Therefore, urocortin causes generalized vasodilatation as follows: heart and stomach>liver, intestine, caecum/colon, skeletal muscle and skin>testes.

Original languageEnglish
Pages (from-to)317-321
Number of pages5
JournalEuropean Journal of Pharmacology
Volume466
Issue number3
DOIs
Publication statusPublished - Apr 18 2003

Keywords

  • Arterial conductance
  • Arterial pressure
  • Blood flow
  • Cardiac output
  • Peripheral resistance
  • Urocortin

ASJC Scopus subject areas

  • Pharmacology

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