Reduction by morphine of human postprandial insulin release is secondary to inhibition of gastrointestinal motility

S. N. Sullivan, M. G. Lee, S. R. Bloom, L. Lamki, J. Dupré

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The effect of morphine (0.1 mg/kg) on insulin secretion stimulated by oral, intraduodenal, or intravenous administration of glucose was studied in seven healthy volunteers. When glucose was given intravenously, morphine had no effect on plasma glucose, insulin, glucose-dependent insulinotropic polypeptide (GIP), or pancreatic glucagon. Following oral glucose, morphine slowed gastric emptying and reduced plasma concentrations of glucose, insulin, and GIP. During intraduodenal infusion of glucose, insulin concentrations in plasma were also decreased by morphine, an effect best explained by decreased small intestinal transit with delayed absorption of glucose and delayed release of GIP. We conclude that clinically relevant doses of morphine has no direct effect on insulin secretion and that the changes observed were secondary to slowed gastric emptying and small intestinal transit.

Original languageEnglish
Pages (from-to)324-328
Number of pages5
JournalDiabetes
Volume35
Issue number3
Publication statusPublished - 1986

Fingerprint

Gastrointestinal Motility
Morphine
Insulin
Glucose
Gastric Emptying
Pancreatic Polypeptide
Peptides
Glucagon
Intravenous Administration
Oral Administration
Healthy Volunteers

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

Cite this

Reduction by morphine of human postprandial insulin release is secondary to inhibition of gastrointestinal motility. / Sullivan, S. N.; Lee, M. G.; Bloom, S. R.; Lamki, L.; Dupré, J.

In: Diabetes, Vol. 35, No. 3, 1986, p. 324-328.

Research output: Contribution to journalArticle

Sullivan, S. N. ; Lee, M. G. ; Bloom, S. R. ; Lamki, L. ; Dupré, J. / Reduction by morphine of human postprandial insulin release is secondary to inhibition of gastrointestinal motility. In: Diabetes. 1986 ; Vol. 35, No. 3. pp. 324-328.
@article{0f64dd8fe5e2425aaf8eb68d6d78eb00,
title = "Reduction by morphine of human postprandial insulin release is secondary to inhibition of gastrointestinal motility",
abstract = "The effect of morphine (0.1 mg/kg) on insulin secretion stimulated by oral, intraduodenal, or intravenous administration of glucose was studied in seven healthy volunteers. When glucose was given intravenously, morphine had no effect on plasma glucose, insulin, glucose-dependent insulinotropic polypeptide (GIP), or pancreatic glucagon. Following oral glucose, morphine slowed gastric emptying and reduced plasma concentrations of glucose, insulin, and GIP. During intraduodenal infusion of glucose, insulin concentrations in plasma were also decreased by morphine, an effect best explained by decreased small intestinal transit with delayed absorption of glucose and delayed release of GIP. We conclude that clinically relevant doses of morphine has no direct effect on insulin secretion and that the changes observed were secondary to slowed gastric emptying and small intestinal transit.",
author = "Sullivan, {S. N.} and Lee, {M. G.} and Bloom, {S. R.} and L. Lamki and J. Dupr{\'e}",
year = "1986",
language = "English",
volume = "35",
pages = "324--328",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association Inc.",
number = "3",

}

TY - JOUR

T1 - Reduction by morphine of human postprandial insulin release is secondary to inhibition of gastrointestinal motility

AU - Sullivan, S. N.

AU - Lee, M. G.

AU - Bloom, S. R.

AU - Lamki, L.

AU - Dupré, J.

PY - 1986

Y1 - 1986

N2 - The effect of morphine (0.1 mg/kg) on insulin secretion stimulated by oral, intraduodenal, or intravenous administration of glucose was studied in seven healthy volunteers. When glucose was given intravenously, morphine had no effect on plasma glucose, insulin, glucose-dependent insulinotropic polypeptide (GIP), or pancreatic glucagon. Following oral glucose, morphine slowed gastric emptying and reduced plasma concentrations of glucose, insulin, and GIP. During intraduodenal infusion of glucose, insulin concentrations in plasma were also decreased by morphine, an effect best explained by decreased small intestinal transit with delayed absorption of glucose and delayed release of GIP. We conclude that clinically relevant doses of morphine has no direct effect on insulin secretion and that the changes observed were secondary to slowed gastric emptying and small intestinal transit.

AB - The effect of morphine (0.1 mg/kg) on insulin secretion stimulated by oral, intraduodenal, or intravenous administration of glucose was studied in seven healthy volunteers. When glucose was given intravenously, morphine had no effect on plasma glucose, insulin, glucose-dependent insulinotropic polypeptide (GIP), or pancreatic glucagon. Following oral glucose, morphine slowed gastric emptying and reduced plasma concentrations of glucose, insulin, and GIP. During intraduodenal infusion of glucose, insulin concentrations in plasma were also decreased by morphine, an effect best explained by decreased small intestinal transit with delayed absorption of glucose and delayed release of GIP. We conclude that clinically relevant doses of morphine has no direct effect on insulin secretion and that the changes observed were secondary to slowed gastric emptying and small intestinal transit.

UR - http://www.scopus.com/inward/record.url?scp=0022656212&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022656212&partnerID=8YFLogxK

M3 - Article

VL - 35

SP - 324

EP - 328

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 3

ER -