Recurrent stent thrombosis with dual antiplatelet resistance: The role of platelet function testing

Sunil Nadar, Farhan Gohar, James Cotton

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Platelet activation is an important part of the pathophysiology of acute coronary syndromes. Inhibition of this by antiplatelet agents forms an important part of the management of this condition. Recently, there has been considerable interest in the variability of platelet response to these drugs and the need to tailor the dose of antiplatelet agents according to the response. Here, we present a patient who had repeated episodes of stent thrombosis and was found to have decreased response to clopidogrel and aspirin (clopidogrel and aspirin resistance) with the use of the Accumetrics VerifyNow™ analyser. We have also reviewed the literature on this subject. Our recommendation is that patients who have recurrent stent thrombosis or thrombotic events on dual antiplatelet agents should have their antiplatelet therapy response checked and have their antiplatelet agents tailored accordingly. Copyright Medinews (Cardiology) Limited Reproduction Prohibited.

Original languageEnglish
Pages (from-to)246-248
Number of pages3
JournalBritish Journal of Cardiology
Volume18
Issue number5-6
DOIs
Publication statusPublished - Oct 2011

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Keywords

  • Aspirin resistance
  • Clopidogrel resistance
  • Percutaneous coronary intervention
  • Stent thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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