Abstract
Essentials Inherited factor XIII deficiency is a very rare bleeding disorder. We used recombinant factor XIII-A in a pregnant patient with factor XIII-A subunit deficiency. The patient had a successful pregnancy outcome with no pregnancy related complications. The dose of recombinant factor XIII-A was minimized by using frequent trough level monitoring. Summary: Inherited factor XIII deficiency is a very rare bleeding disorder, and is one of the causes of recurrent pregnancy loss. The use of plasma-derived FXIII to improve pregnancy outcomes has been reported. We report a 26-year-old woman with FXIII A-subunit (FXIII-A) deficiency who was treated with recombinant FXIII-A and had a successful pregnancy outcome with no pregnancy-related complications. Our case illustrates that the dose of recombinant FXIII-A can be minimized and adjusted on the basis of frequent trough level monitoring.
Original language | English |
---|---|
Pages (from-to) | 1052-1054 |
Number of pages | 3 |
Journal | Journal of Thrombosis and Haemostasis |
Volume | 16 |
Issue number | 6 |
DOIs |
|
Publication status | Published - Jun 2018 |
Keywords
- Hepacivirus
- abortion, habitual
- cryoprecipitate coagulum
- factor XIII deficiency
- factor XIII-A
ASJC Scopus subject areas
- Hematology