Recombinant factor XIII A-subunit in a patient with factor XIII deficiency and recurrent pregnancy loss

Murtadha Al-Khabori, Anil Pathare, M. Menegatti, F. Peyvandi

Research output: Contribution to journalComment/debate

Abstract

Essentials Inherited factor XIII deficiency is a very rare bleeding disorder. We used recombinant factor XIII-A in a pregnant patient with factor XIII-A subunit deficiency. The patient had a successful pregnancy outcome with no pregnancy related complications. The dose of recombinant factor XIII-A was minimized by using frequent trough level monitoring. Summary: Inherited factor XIII deficiency is a very rare bleeding disorder, and is one of the causes of recurrent pregnancy loss. The use of plasma-derived FXIII to improve pregnancy outcomes has been reported. We report a 26-year-old woman with FXIII A-subunit (FXIII-A) deficiency who was treated with recombinant FXIII-A and had a successful pregnancy outcome with no pregnancy-related complications. Our case illustrates that the dose of recombinant FXIII-A can be minimized and adjusted on the basis of frequent trough level monitoring.

Original languageEnglish
Pages (from-to)1052-1054
Number of pages3
JournalJournal of Thrombosis and Haemostasis
Volume16
Issue number6
DOIs
Publication statusPublished - Jun 1 2018

Fingerprint

Factor XIII
Pregnancy Outcome
Pregnancy Complications
Pregnancy
Factor XIII Deficiency
Hemorrhage

Keywords

  • abortion, habitual
  • cryoprecipitate coagulum
  • factor XIII deficiency
  • factor XIII-A
  • Hepacivirus

ASJC Scopus subject areas

  • Hematology

Cite this

Recombinant factor XIII A-subunit in a patient with factor XIII deficiency and recurrent pregnancy loss. / Al-Khabori, Murtadha; Pathare, Anil; Menegatti, M.; Peyvandi, F.

In: Journal of Thrombosis and Haemostasis, Vol. 16, No. 6, 01.06.2018, p. 1052-1054.

Research output: Contribution to journalComment/debate

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AU - Al-Khabori, Murtadha

AU - Pathare, Anil

AU - Menegatti, M.

AU - Peyvandi, F.

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Essentials Inherited factor XIII deficiency is a very rare bleeding disorder. We used recombinant factor XIII-A in a pregnant patient with factor XIII-A subunit deficiency. The patient had a successful pregnancy outcome with no pregnancy related complications. The dose of recombinant factor XIII-A was minimized by using frequent trough level monitoring. Summary: Inherited factor XIII deficiency is a very rare bleeding disorder, and is one of the causes of recurrent pregnancy loss. The use of plasma-derived FXIII to improve pregnancy outcomes has been reported. We report a 26-year-old woman with FXIII A-subunit (FXIII-A) deficiency who was treated with recombinant FXIII-A and had a successful pregnancy outcome with no pregnancy-related complications. Our case illustrates that the dose of recombinant FXIII-A can be minimized and adjusted on the basis of frequent trough level monitoring.

AB - Essentials Inherited factor XIII deficiency is a very rare bleeding disorder. We used recombinant factor XIII-A in a pregnant patient with factor XIII-A subunit deficiency. The patient had a successful pregnancy outcome with no pregnancy related complications. The dose of recombinant factor XIII-A was minimized by using frequent trough level monitoring. Summary: Inherited factor XIII deficiency is a very rare bleeding disorder, and is one of the causes of recurrent pregnancy loss. The use of plasma-derived FXIII to improve pregnancy outcomes has been reported. We report a 26-year-old woman with FXIII A-subunit (FXIII-A) deficiency who was treated with recombinant FXIII-A and had a successful pregnancy outcome with no pregnancy-related complications. Our case illustrates that the dose of recombinant FXIII-A can be minimized and adjusted on the basis of frequent trough level monitoring.

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