Recent progress in the total synthesis of naphthyridinomycin and lemonomycin tetrahydroisoquinoline antitumor antibiotics (TAAs)

Peter Siengalewicz, Uwe Rinner, Johann Mulzer

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

In this tutorial review, which should be of general interest to synthetic organic chemists at large, recent progress in the total synthesis of the tetrahydroisoquinoline antitumor antibiotics cyanocycline A, naphthyridinomycin, bioxalomycin α2, and lemonomycin is highlighted in detail and some biological background information is given as well. Preparations of truncated derivatives and uncompleted synthetic approaches are also described. The literature coverage includes the newest research results through the year 2008.

Original languageEnglish
Pages (from-to)2676-2690
Number of pages15
JournalChemical Society Reviews
Volume37
Issue number12
DOIs
Publication statusPublished - 2008

ASJC Scopus subject areas

  • Chemistry(all)

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