Recent advances on utilization of bioprinting for tumor modeling

Y. Cagri Oztan, Nashat Nawafleh, Yiqun Zhou, Piumi Y. Liyanage, Sajini D. Hettiarachchi, Elif S. Seven, Roger M. Leblanc, Allal Ouhtit, Emrah Celik*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

18 Citations (Scopus)


Despite the recent rigorous studies towards a possible cure, cancer still remains as one of the most daunting problems faced by the humanity. Currently utilized two-dimensional cancer models are known to have variousinsupersable limitations such as insufficient biomimicry of the heterogeneous conditions of tumors and their three-dimensional structures. Discrepancies between the laboratory models and the actual tumor environment significantly impair a thorough comprehension of the carcinogenesis process and development of successful remedies against cancer. Modeling tumor microenvironments through bioprinting poses strong potential to minimize the effects of the aforementioned issues thanks to its freeform nature, adaptability, customizability, scalability and diversity. Numerous research studies involving three-dimensional modeling of various cancer types using bioprinting technologies have been reported, recently. In this review, we provide a broad summary of these studies to help better represent their potential and analyze their contribution to cancer research.

Original languageEnglish
Article numbere00079
Publication statusPublished - Jun 2020
Externally publishedYes


  • 3D Microenvironment
  • 3D Printing
  • Bioprinting
  • Cancer
  • Cancer modelling

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering
  • Computer Science Applications


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