Rapid and efficient microwave-assisted copper(0)-catalyzed ullmann coupling reaction: General access to anilinoanthraquinone derivatives

Younis Baqi, Christa E. Muller

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Figure presented The synthesis of anilinoanthraquinones 3a-z was achieved by a new, Cu(0)-catalyzed, microwave-assisted Ullmann coupling reaction of bromaminic acid (1) with aniline derivatives 2a-z in phosphate buffer. Good to excellent isolated yields were obtained within only 2-20 min at 80-120 °C and 40-100 W. The new procedure provides the first general access to anilinoanthraquinones, furnishing a number of previously inaccessible compounds. It is superior to classical methods in all aspects, including yields, reaction time, and versatility.

Original languageEnglish
Pages (from-to)1271-1274
Number of pages4
JournalOrganic Letters
Issue number7
Publication statusPublished - Mar 29 2007


ASJC Scopus subject areas

  • Molecular Medicine

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