Rapid and efficient microwave-assisted copper(0)-catalyzed ullmann coupling reaction: General access to anilinoanthraquinone derivatives

Younis Baqi; Christa E. Muller

doi:10.1021/ol070102v

Rapid and efficient microwave-assisted copper(0)-catalyzed ullmann coupling reaction

General access to anilinoanthraquinone derivatives

Younis Baqi, Christa E. Muller

Chemistry

Research output: Contribution to journal › Article

45 Citations (Scopus)

Abstract

Figure presented The synthesis of anilinoanthraquinones 3a-z was achieved by a new, Cu(0)-catalyzed, microwave-assisted Ullmann coupling reaction of bromaminic acid (1) with aniline derivatives 2a-z in phosphate buffer. Good to excellent isolated yields were obtained within only 2-20 min at 80-120 °C and 40-100 W. The new procedure provides the first general access to anilinoanthraquinones, furnishing a number of previously inaccessible compounds. It is superior to classical methods in all aspects, including yields, reaction time, and versatility.

Original language	English
Pages (from-to)	1271-1274
Number of pages	4
Journal	Organic Letters
Volume	9
Issue number	7
DOIs	https://doi.org/10.1021/ol070102v
Publication status	Published - Mar 29 2007

Fingerprint

Microwaves

Copper

Buffers

Phosphates

Derivatives

microwaves

copper

versatility

aniline

reaction time

phosphates

buffers

acids

synthesis

bromamine acid

ASJC Scopus subject areas

Molecular Medicine

Cite this

Baqi, Y., & Muller, C. E. (2007). Rapid and efficient microwave-assisted copper(0)-catalyzed ullmann coupling reaction: General access to anilinoanthraquinone derivatives. Organic Letters, 9(7), 1271-1274. https://doi.org/10.1021/ol070102v

Rapid and efficient microwave-assisted copper(0)-catalyzed ullmann coupling reaction : General access to anilinoanthraquinone derivatives. / Baqi, Younis; Muller, Christa E.

In: Organic Letters, Vol. 9, No. 7, 29.03.2007, p. 1271-1274.

Research output: Contribution to journal › Article

Baqi, Y & Muller, CE 2007, 'Rapid and efficient microwave-assisted copper(0)-catalyzed ullmann coupling reaction: General access to anilinoanthraquinone derivatives', Organic Letters, vol. 9, no. 7, pp. 1271-1274. https://doi.org/10.1021/ol070102v

Baqi Y, Muller CE. Rapid and efficient microwave-assisted copper(0)-catalyzed ullmann coupling reaction: General access to anilinoanthraquinone derivatives. Organic Letters. 2007 Mar 29;9(7):1271-1274. https://doi.org/10.1021/ol070102v

Baqi, Younis ; Muller, Christa E. / Rapid and efficient microwave-assisted copper(0)-catalyzed ullmann coupling reaction : General access to anilinoanthraquinone derivatives. In: Organic Letters. 2007 ; Vol. 9, No. 7. pp. 1271-1274.

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10.1021/ol070102v