Protein Nutrition in Autism

Saravana Babu Chidambaram*, Abid Bhat, Arehally Marappa Mahalakshmi, Bipul Ray, Sunanda Tuladhar, B. S. Sushmitha, B. Saravanan, Manivasagam Thamilarasan, Arokiasamy Justin Thenmozhi, Musthafa Mohamed Essa, Gilles J. Guillemin, M. Walid Qoronfleh

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Autism is a developmental disorder that affects communication and behavior. Although autism can be diagnosed at any age, it is said to be a “developmental disorder” because symptoms generally appear in the first 2 years of life. The primary cause of autism is still not clear and therapy is currently restricted to controlling behavioral abnormalities. However, emerging studies have shown a link between mitochondrial dysfunction and autism. Dietary supplements that promote mitochondrial biogenesis and inhibit the production of oxidative stress have been used to treat autism patients. Dietary adjustments in treating autism is a novel approach to suppress autistic symptoms. Supplementation with antioxidants has been found to not only inhibit cognitive decline but also improve behavioral symptoms in autism. Dietary supplements fortified with vitamins should only be given under the supervision of a physician. A wide range of nutraceuticals are under clinical trials to understand whether they physiologically target mitochondrial pathways and improve the quality of life in autism.

Original languageEnglish
Title of host publicationAdvances in Neurobiology
PublisherSpringer
Pages573-586
Number of pages14
DOIs
Publication statusPublished - Jan 1 2020

Publication series

NameAdvances in Neurobiology
Volume24
ISSN (Print)2190-5215
ISSN (Electronic)2190-5223

Keywords

  • Amino acids
  • ASD
  • Autism
  • Dietary therapy
  • Gluten-free, casein-free (GFCF) diet
  • Malabsorption
  • Mitochondrial dysfunction
  • Nutritional imbalance
  • Peptides
  • Protein maldigestion

ASJC Scopus subject areas

  • Biochemistry
  • Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience

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