Protective influence of Pongamia pinnata (Karanja) on blood ammonia and urea levels in ammonium chloride-induced hyperammonemia

Antihyperammonemic effect of the leaf extract

Musthafa Mohamed Essa, Perumal Subramanian, Ganapathy Suthakar, Tamilarasan Manivasagam, Kadiyala Babu Dakshayani

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The present study was undertaken to investigate the antihyperammonemic efficacy of the leaf extract of Pongamia pinnata, an indigenous plant used in Ayurvedic Medicine in India (PPEt), on blood ammonia, plasma urea, uric acid, non-protein nitrogen and serum creatinine in control and ammonium chloride induced hyperammonemic rats. The levels of blood ammonia, circulatory urea, uric acid, non-protein nitrogen and creatinine increased significantly in rats treated with ammonium chloride and decreased significantly in rats treated with PPEt and ammonium chloride. There were no significant changes in the body weights of the experimental animals when compared to controls. The antihyperammonemic effect of PPEt could be attributed to (1) its nephroprotective effect by means of detoxifying excess urea and creatinine, (2) its free radical scavenging property, and (3) its antioxidant property. The exact mechanism of antihyperammonemic effect PPEt has still to be investigated and isolation of the active constituents is required.

Original languageEnglish
JournalJournal of Applied Biomedicine
Volume3
Issue number3
Publication statusPublished - Sep 2005

Fingerprint

Pongamia
Millettia
Millettia pinnata
Hyperammonemia
Ammonium Chloride
ammonium chloride
Ammonia
leaf extracts
creatinine
Urea
Rats
Creatinine
Blood
nonprotein nitrogen
ammonia
urea
uric acid
Uric Acid
rats
blood

Keywords

  • Ammonium chloride
  • Creatinine
  • Non-protein nitrogen
  • Pongamia pinnata
  • Urea
  • Uric acid

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Neuroscience(all)

Cite this

Protective influence of Pongamia pinnata (Karanja) on blood ammonia and urea levels in ammonium chloride-induced hyperammonemia : Antihyperammonemic effect of the leaf extract. / Essa, Musthafa Mohamed; Subramanian, Perumal; Suthakar, Ganapathy; Manivasagam, Tamilarasan; Dakshayani, Kadiyala Babu.

In: Journal of Applied Biomedicine, Vol. 3, No. 3, 09.2005.

Research output: Contribution to journalArticle

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