TY - CHAP
T1 - Protective Effects of Curcumin on Endothelium
T2 - An Updated Review
AU - Alidadi, Mona
AU - Liberale, Luca
AU - Montecucco, Fabrizio
AU - Majeed, Muhammed
AU - Al-Rasadi, Khalid
AU - Banach, Maciej
AU - Jamialahmadi, Tannaz
AU - Sahebkar, Amirhossein
N1 - © 2021. The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - Endothelial dysfunction is the common early stage of most cardiovascular afflictions. The endothelium is considered the main mediator of vascular homeostasis via its vasodilator, anti-inflammatory and anticoagulant properties. Among the different endothelial-derived mediators, nitric oxide is produced by nitric oxide synthase and has a critical role in regulating endothelial function. Physiological and pathological processes such as aging and diabetes mellitus are associated with disturbances of endothelial function which, at least at the earliest stage, can be reversed by lifestyle and pharmacological intervention to reduce the risk of incident cardiovascular diseases. Among dietary strategies, curcumin is a cheap and safe nutraceutical polyphenol with proven antioxidant and anti-inflammatory properties. Given the important role of such processes in the development of endothelium dysfunction, a role for curcumin in the prevention or treatment of this condition has been hypothesized. This review summarizes the available literature on the beneficial role of curcumin on vascular endothelial function.
AB - Endothelial dysfunction is the common early stage of most cardiovascular afflictions. The endothelium is considered the main mediator of vascular homeostasis via its vasodilator, anti-inflammatory and anticoagulant properties. Among the different endothelial-derived mediators, nitric oxide is produced by nitric oxide synthase and has a critical role in regulating endothelial function. Physiological and pathological processes such as aging and diabetes mellitus are associated with disturbances of endothelial function which, at least at the earliest stage, can be reversed by lifestyle and pharmacological intervention to reduce the risk of incident cardiovascular diseases. Among dietary strategies, curcumin is a cheap and safe nutraceutical polyphenol with proven antioxidant and anti-inflammatory properties. Given the important role of such processes in the development of endothelium dysfunction, a role for curcumin in the prevention or treatment of this condition has been hypothesized. This review summarizes the available literature on the beneficial role of curcumin on vascular endothelial function.
KW - Adhesion molecule
KW - Arterial dysfunction
KW - Atherosclerosis
KW - Curcumin
KW - Curcuminoid
KW - Endothelial dysfunction
KW - Endothelium
KW - FMD
KW - Nitric oxide bioavailability
KW - Humans
KW - Curcumin/pharmacology
KW - Nitric Oxide
KW - Antioxidants
KW - Cardiovascular Diseases/drug therapy
KW - Endothelium, Vascular
UR - http://www.scopus.com/inward/record.url?scp=85112602893&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85112602893&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/cd8b35ad-9810-37a4-ab79-ee46a8479777/
U2 - 10.1007/978-3-030-56153-6_6
DO - 10.1007/978-3-030-56153-6_6
M3 - Chapter
C2 - 34331686
AN - SCOPUS:85112602893
VL - 1291
T3 - Advances in experimental medicine and biology
SP - 103
EP - 119
BT - Advances in Experimental Medicine and Biology
PB - Springer
ER -
