Protective Effects of Curcumin on Endothelium: An Updated Review

Mona Alidadi, Luca Liberale, Fabrizio Montecucco, Muhammed Majeed, Khalid Al-Rasadi, Maciej Banach, Tannaz Jamialahmadi, Amirhossein Sahebkar*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Endothelial dysfunction is the common early stage of most cardiovascular afflictions. The endothelium is considered the main mediator of vascular homeostasis via its vasodilator, anti-inflammatory and anticoagulant properties. Among the different endothelial-derived mediators, nitric oxide is produced by nitric oxide synthase and has a critical role in regulating endothelial function. Physiological and pathological processes such as aging and diabetes mellitus are associated with disturbances of endothelial function which, at least at the earliest stage, can be reversed by lifestyle and pharmacological intervention to reduce the risk of incident cardiovascular diseases. Among dietary strategies, curcumin is a cheap and safe nutraceutical polyphenol with proven antioxidant and anti-inflammatory properties. Given the important role of such processes in the development of endothelium dysfunction, a role for curcumin in the prevention or treatment of this condition has been hypothesized. This review summarizes the available literature on the beneficial role of curcumin on vascular endothelial function.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer
Pages103-119
Number of pages17
DOIs
Publication statusPublished - 2021

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1291
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Adhesion molecule
  • Arterial dysfunction
  • Atherosclerosis
  • Curcumin
  • Curcuminoid
  • Endothelial dysfunction
  • Endothelium
  • FMD
  • Nitric oxide bioavailability

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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