Protective effect of curcumin on pulmonary and cardiovascular effects induced by repeated exposure to diesel exhaust particles in mice

Abderrahim Nemmar, Deepa Subramaniyan, Badreldin H. Ali

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Particulate air pollution has been associated with increased risk of cardiopulmonary diseases. However, the underlying mechanisms are not fully understood. We have previously demonstrated that single dose exposure to diesel exhaust particle (DEP) causes lung inflammation and peripheral thrombotic events. Here, we exposed mice with repeated doses of DEP (15μg/animal) every 2nd day for 6 days (a total of 4 exposures), and measured several cardiopulmonary endpoints 48 h after the end of the treatments. Moreover, the potential protective effect of curcumin (the yellow pigment isolated from turmeric) on DEP-induced cardiopulmonary toxicity was assessed. DEP exposure increased macrophage and neutrophil numbers, tumor necrosis factor α (TNF α) in the bronchoalveolar lavage (BAL) fluid, and enhanced airway resistance to methacoline measured invasively using Flexivent. DEP also significantly increased plasma C-reactive protein (CRP) and TNF α concentrations, systolic blood pressure (SBP) as well as the pial arteriolar thrombosis. It also significantly enhanced the plasma D-dimer and plasminogen activator inhibitor-1 (PAI-1). Pretreatment with curcumin by oral gavage (45 mg/kg) 1h before exposure to DEP significantly prevented the influx of inflammatory cells and the increase of TNF α in BAL, and the increased airway resistance caused by DEP. Likewise, curcumin prevented the increase of SBP, CRP, TNF α, D-dimer and PAI-1. The thrombosis was partially but significantly mitigated. In conclusion, repeated exposure to DEP induced lung and systemic inflammation characterized by TNFα release, increased SBP, and accelerated coagulation. Our findings indicate that curcumin is a potent anti-inflammatory agent that prevents the release of TNFα and protects against the pulmonary and cardiovascular effects of DEP.

Original languageEnglish
Article numbere39554
JournalPLoS One
Volume7
Issue number6
DOIs
Publication statusPublished - Jun 22 2012

Fingerprint

Vehicle Emissions
Curcumin
curcumin
Particles (particulate matter)
protective effect
tumor necrosis factors
lungs
Lung
mice
Tumor Necrosis Factor-alpha
Blood Pressure
Blood pressure
systolic blood pressure
Airway Resistance
thrombosis
Plasminogen Activator Inhibitor 1
C-reactive protein
C-Reactive Protein
Pneumonia
Thrombosis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Protective effect of curcumin on pulmonary and cardiovascular effects induced by repeated exposure to diesel exhaust particles in mice. / Nemmar, Abderrahim; Subramaniyan, Deepa; Ali, Badreldin H.

In: PLoS One, Vol. 7, No. 6, e39554, 22.06.2012.

Research output: Contribution to journalArticle

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