Protective Effect of Antioxidants on Neuronal Dysfunction and Plasticity in Huntington's Disease

Thirunavukkarasu Velusamy, Archana S. Panneerselvam, Meera Purushottam, Muthuswamy Anusuyadevi, Pramod Kumar Pal, Sanjeev Jain, Musthafa Mohamed Essa, Gilles J. Guillemin, Mahesh Kandasamy

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

Huntington's disease (HD) is characterised by movement disorders, cognitive impairments, and psychiatric problems. The abnormal generation of reactive oxygen species and the resulting oxidative stress-induced mitochondrial damage in neurons upon CAG mutations in the HTT gene have been hypothesized as the contributing factors of neurodegeneration in HD. The potential use of antioxidants against free radical toxicity has been an emerging field in the management of ageing and many neurodegenerative disorders. Neural stem cells derived adult neurogenesis represents the regenerative capacity of the adult brain. The process of adult neurogenesis has been implicated in the cognitive functions of the brain and is highly modulated positively by different factors including antioxidants. The supportive role of antioxidants to reduce the severity of HD via promoting the functional neurogenesis and neuroprotection in the pathological adult brain has great promise. This review comprehends the recent studies describing the therapeutic roles of antioxidants in HD and other neurologic disorders and highlights the scope of using antioxidants to promote adult neurogenesis in HD. It also advocates a new line of research to delineate the mechanisms by which antioxidants promote adult neurogenesis in HD.

Original languageEnglish
Article number3279061
JournalOxidative Medicine and Cellular Longevity
Volume2017
DOIs
Publication statusPublished - 2017

Fingerprint

Neuronal Plasticity
Huntington Disease
Neurogenesis
Plasticity
Antioxidants
Brain
Oxidative stress
Neural Stem Cells
Movement Disorders
Nervous System Diseases
Stem cells
Neurodegenerative Diseases
Cognition
Neurons
Free Radicals
Psychiatry
Toxicity
Reactive Oxygen Species
Oxidative Stress
Genes

ASJC Scopus subject areas

  • Biochemistry
  • Ageing
  • Cell Biology

Cite this

Velusamy, T., Panneerselvam, A. S., Purushottam, M., Anusuyadevi, M., Pal, P. K., Jain, S., ... Kandasamy, M. (2017). Protective Effect of Antioxidants on Neuronal Dysfunction and Plasticity in Huntington's Disease. Oxidative Medicine and Cellular Longevity, 2017, [3279061]. https://doi.org/10.1155/2017/3279061

Protective Effect of Antioxidants on Neuronal Dysfunction and Plasticity in Huntington's Disease. / Velusamy, Thirunavukkarasu; Panneerselvam, Archana S.; Purushottam, Meera; Anusuyadevi, Muthuswamy; Pal, Pramod Kumar; Jain, Sanjeev; Essa, Musthafa Mohamed; Guillemin, Gilles J.; Kandasamy, Mahesh.

In: Oxidative Medicine and Cellular Longevity, Vol. 2017, 3279061, 2017.

Research output: Contribution to journalReview article

Velusamy, T, Panneerselvam, AS, Purushottam, M, Anusuyadevi, M, Pal, PK, Jain, S, Essa, MM, Guillemin, GJ & Kandasamy, M 2017, 'Protective Effect of Antioxidants on Neuronal Dysfunction and Plasticity in Huntington's Disease', Oxidative Medicine and Cellular Longevity, vol. 2017, 3279061. https://doi.org/10.1155/2017/3279061
Velusamy, Thirunavukkarasu ; Panneerselvam, Archana S. ; Purushottam, Meera ; Anusuyadevi, Muthuswamy ; Pal, Pramod Kumar ; Jain, Sanjeev ; Essa, Musthafa Mohamed ; Guillemin, Gilles J. ; Kandasamy, Mahesh. / Protective Effect of Antioxidants on Neuronal Dysfunction and Plasticity in Huntington's Disease. In: Oxidative Medicine and Cellular Longevity. 2017 ; Vol. 2017.
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