TY - CHAP
T1 - Properties, classification and applications of lantibiotics from Gram-positive bacteria
AU - Fernandes, Abigail
AU - Yadav, Pranay
AU - Nalawade, Omkar
AU - Joshi, Sanket
AU - Jobby, Renitta
N1 - Publisher Copyright:
© 2023 Elsevier Inc. All rights reserved.
PY - 2023/1/1
Y1 - 2023/1/1
N2 - During the last few decades a plethora of research has described the gene-encoded antimicrobial peptides from various organisms. Gram-positive bacteria are well known to synthesize ribosomal antibacterial peptides known as lantibiotics. A large number of these peptides have gained increasing attention from researchers due to their ability to hinder microbes residing in the same niche. The biosynthesis of lantibiotics comprises posttranslational modifications. Lantibiotics present an unprecedented structural feature of intramolecular rings that are added by the thioether amino acids lanthionine and 3-methyl lanthionine. This class of bacteriocin has evolved into two different lineages, type A and B depending upon the structural and functional properties. This chapter summarizes the current knowledge of the structures and properties of the relatively diverse lantibiotics from Gram-positive organisms. An emphasis is made on the properties of recently described peptides. Furthermore, the classes and mode of action of these peptides are described. An outlook of potential applications beyond food preservatives has also been presented that will facilitate the widespread implementation of these novel peptides.
AB - During the last few decades a plethora of research has described the gene-encoded antimicrobial peptides from various organisms. Gram-positive bacteria are well known to synthesize ribosomal antibacterial peptides known as lantibiotics. A large number of these peptides have gained increasing attention from researchers due to their ability to hinder microbes residing in the same niche. The biosynthesis of lantibiotics comprises posttranslational modifications. Lantibiotics present an unprecedented structural feature of intramolecular rings that are added by the thioether amino acids lanthionine and 3-methyl lanthionine. This class of bacteriocin has evolved into two different lineages, type A and B depending upon the structural and functional properties. This chapter summarizes the current knowledge of the structures and properties of the relatively diverse lantibiotics from Gram-positive organisms. An emphasis is made on the properties of recently described peptides. Furthermore, the classes and mode of action of these peptides are described. An outlook of potential applications beyond food preservatives has also been presented that will facilitate the widespread implementation of these novel peptides.
KW - Bacteriocin
KW - anticancer
KW - antimicrobial peptides
KW - nisin
KW - posttranslational modifications
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UR - https://www.mendeley.com/catalogue/a6b7774d-aa24-3f12-aa5a-a0018a165e15/
U2 - 10.1016/b978-0-323-99141-4.00016-3
DO - 10.1016/b978-0-323-99141-4.00016-3
M3 - Chapter
AN - SCOPUS:85152850942
SN - 9780323991414
T3 - Lantibiotics as Alternative Therapeutics
SP - 411
EP - 425
BT - Lantibiotics as Alternative Therapeutics
PB - Elsevier
ER -